Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCN6
  • Mouse genes Ccn6
  • Rat genes Ccn6
  • Zfish genes ccn6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccn6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ccn6	IPI	UniProtKB:Q61091	Zfish	PMID:17823661
Molecular Function	GO:0005515	protein binding	ccn6	IPI	UniProtKB:O75581	Zfish	PMID:17823661
Cellular Component	GO:0005615	extracellular space	CCN6	IDA		Human	PMID:27252383
Cellular Component	GO:0005739	mitochondrion	CCN6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	CCN6	IDA		Human	PMID:27252383
Biological Process	GO:0009060	aerobic respiration	ccn6	IMP	ZFIN:ZDB-MRPHLNO-211029-1	Zfish	PMID:33644064
Biological Process	GO:0030509	BMP signaling pathway	ccn6	IGI	ZFIN:ZDB-GENE-041001-86,ZFIN:ZDB-GENE-980526-474	Zfish	PMID:17823661
Biological Process	GO:0051216	cartilage development	ccn6	IMP	ZFIN:ZDB-MRPHLNO-071228-5	Zfish	PMID:17823661
Biological Process	GO:0051216	cartilage development	ccn6	IMP	ZFIN:ZDB-MRPHLNO-071228-4	Zfish	PMID:17823661
Biological Process	GO:0009953	dorsal/ventral pattern formation	ccn6	IMP		Zfish	PMID:17823661
Biological Process	GO:0016525	negative regulation of angiogenesis	CCN6	IDA		Human	PMID:12082632
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	ccn6	IGI	ZFIN:ZDB-GENE-041001-86,ZFIN:ZDB-GENE-980526-474	Zfish	PMID:17823661
Biological Process	GO:0008285	negative regulation of cell population proliferation	CCN6	IDA		Human	PMID:12082632
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	ccn6	IGI	ZFIN:ZDB-GENE-041001-86,ZFIN:ZDB-GENE-980526-332	Zfish	PMID:17823661
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	CCN6	IMP		Human	PMID:27252383
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	CCN6	IMP		Human	PMID:27252383

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern