Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCNA2
  • Mouse genes Ccna2
  • Rat genes Ccna2
  • Zfish genes ccna2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccna2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	CCNA2	IDA		Human	PMID:1312467
Molecular Function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	ccna2	IMP	ZFIN:ZDB-GENO-111228-3	Zfish	PMID:22072796
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:12244298
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:12941338
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:15189033
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:15239650
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:15890360
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P38936	Human	PMID:15890360
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P46527	Human	PMID:15890360
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P03129	Human	PMID:16061792
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:16209941
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P46527	Human	PMID:16209941
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:16431923
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:17254966
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P46527	Human	PMID:17254966
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:18177895
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P46527	Human	PMID:18177895
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P46527	Human	PMID:20596027
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:Q0VD86	Human	PMID:21540187
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:Q96PU4	Human	PMID:21952639
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P03129	Human	PMID:22810586
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:24358021
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P31749	Human	PMID:24670654
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P38936	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P46527	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P38936	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P46527	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P38936	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P46527	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:7630397
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P03070	Human	PMID:8411358
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:8684460
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P46527	Human	PMID:8684460
Molecular Function	GO:0005515	protein binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:8756328
Molecular Function	GO:0005515	protein binding	Ccna2	IPI	UniProtKB:P11440|UniProtKB:P97377	Mouse	MGI:MGI:4412428|PMID:19592082
Molecular Function	GO:0005515	protein binding	Ccna2	IPI	UniProtKB:P24941	Mouse	MGI:MGI:5918810|PMID:21565702
Molecular Function	GO:0005515	protein binding	Ccna2	IPI	PR:Q9JJG5	Mouse	PMID:11331592
Molecular Function	GO:0005515	protein binding	Ccna2	IPI	PR:Q9JL10	Mouse	PMID:11331592
Molecular Function	GO:0005515	protein binding	Ccna2	IPI	UniProtKB:Q6PEC4	Rat	PMID:18356301|RGD:13432308
Molecular Function	GO:0019904	protein domain specific binding	CCNA2	IPI	UniProtKB:P46527	Human	PMID:15024385
Molecular Function	GO:0019901	protein kinase binding	CCNA2	IPI	UniProtKB:P06493	Human	PMID:1312467
Molecular Function	GO:0019901	protein kinase binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:1312467
Molecular Function	GO:0019901	protein kinase binding	CCNA2	IPI	UniProtKB:P24941	Human	PMID:15024385
Molecular Function	GO:0019901	protein kinase binding	Ccna2	IPI	PR:P97377	Mouse	PMID:11981756
Cellular Component	GO:0097124	cyclin A2-CDK2 complex	CCNA2	IPI		Human	PMID:12244298
Cellular Component	GO:0097124	cyclin A2-CDK2 complex	CCNA2	IDA		Human	PMID:11746698
Cellular Component	GO:0097124	cyclin A2-CDK2 complex	CCNA2	IDA		Human	PMID:1312467
Cellular Component	GO:0097124	cyclin A2-CDK2 complex	CCNA2	IDA		Human	PMID:15024385
Cellular Component	GO:0097124	cyclin A2-CDK2 complex	CCNA2	IDA		Human	PMID:8684460
Cellular Component	GO:0097124	cyclin A2-CDK2 complex	Ccna2	IDA		Mouse	PMID:7739547
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	CCNA2	IDA		Human	PMID:1312467
Cellular Component	GO:0005737	cytoplasm	CCNA2	IDA		Human	PMID:1312467
Cellular Component	GO:0005737	cytoplasm	CCNA2	IDA		Human	PMID:23791195
Cellular Component	GO:0005737	cytoplasm	Ccna2	IDA		Mouse	PMID:15159393
Cellular Component	GO:0005829	cytosol	CCNA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001939	female pronucleus	Ccna2	IDA		Mouse	PMID:16137671
Cellular Component	GO:0001940	male pronucleus	Ccna2	IDA		Mouse	PMID:16137671
Cellular Component	GO:0005654	nucleoplasm	CCNA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CCNA2	IDA		Human	PMID:8245034
Cellular Component	GO:0005634	nucleus	CCNA2	IDA		Human	PMID:1312467
Cellular Component	GO:0005634	nucleus	CCNA2	IDA		Human	PMID:16109376
Cellular Component	GO:0005634	nucleus	Ccna2	IDA		Mouse	PMID:15159393
Cellular Component	GO:0005634	nucleus	Ccna2	IDA		Rat	PMID:25289051|RGD:10054493
Biological Process	GO:0031100	animal organ regeneration	Ccna2	IEP		Rat	PMID:9806355|RGD:2293353
Biological Process	GO:0044843	cell cycle G1/S phase transition	CCNA2	IDA		Human	PMID:1312467
Biological Process	GO:0071314	cellular response to cocaine	Ccna2	IEP		Rat	PMID:18593214|RGD:10054470
Biological Process	GO:0071392	cellular response to estradiol stimulus	Ccna2	IEP		Rat	PMID:9275057|RGD:10054467
Biological Process	GO:0071456	cellular response to hypoxia	Ccna2	IEP		Rat	PMID:25289051|RGD:10054493
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	Ccna2	IEP		Rat	PMID:9275057|RGD:10054467
Biological Process	GO:0044320	cellular response to leptin stimulus	Ccna2	IEP		Rat	PMID:17303663|RGD:2289137
Biological Process	GO:0071373	cellular response to luteinizing hormone stimulus	Ccna2	IEP		Rat	PMID:9275057|RGD:10054467
Biological Process	GO:0071732	cellular response to nitric oxide	Ccna2	IEP		Rat	PMID:9610538|RGD:10054495
Biological Process	GO:0071407	cellular response to organic cyclic compound	Ccna2	IEP		Rat	PMID:10683356|RGD:2316080
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	Ccna2	IEP		Rat	PMID:18667424|RGD:10054494
Biological Process	GO:0090102	cochlea development	Ccna2	IEP		Rat	PMID:19429027|RGD:10054469
Biological Process	GO:0006351	DNA-templated transcription	Ccna2	IMP		Mouse	PMID:16137671
Biological Process	GO:0006351	DNA-templated transcription	Ccna2	IGI	MGI:MGI:104772	Mouse	PMID:16137671
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	CCNA2	IDA		Human	PMID:1312467
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Ccna2	IGI	MGI:MGI:104772	Mouse	PMID:16137671
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Ccna2	IMP		Mouse	PMID:16137671
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Ccna2	IMP		Rat	PMID:15737994|RGD:2293349
Biological Process	GO:0043687	post-translational protein modification	CCNA2	IDA		Human	PMID:11746698
Biological Process	GO:0007265	Ras protein signal transduction	CCNA2	IEP		Human	PMID:9054499
Biological Process	GO:0006275	regulation of DNA replication	CCNA2	IMP		Human	PMID:17234884
Biological Process	GO:0032355	response to estradiol	Ccna2	IEP		Rat	PMID:9806355|RGD:2293353
Biological Process	GO:0033762	response to glucagon	Ccna2	IEP		Rat	PMID:10405333|RGD:2293352
Biological Process	GO:0060041	retina development in camera-type eye	ccna2	IMP	ZFIN:ZDB-GENO-040713-11	Zfish	PMID:15716491
Biological Process	GO:0060041	retina development in camera-type eye	ccna2	IMP	ZFIN:ZDB-GENO-020430-18	Zfish	PMID:15716491

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern