Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ccr2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CCR2
- Mouse genes Ccr2
- Rat genes Ccr2
- Zfish genes cabz01093075.1,ccr11.1,ccr2,ccr8.1,si:cabz01093077.1,si:ch211-207g17.3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016493	C-C chemokine receptor activity	Ccr2	IDA		Mouse	PMID:8662823
Molecular Function	GO:0016493	C-C chemokine receptor activity	Ccr2	IDA		Mouse	PMID:8631787
Molecular Function	GO:0031727	CCR2 chemokine receptor binding	CCR2	IDA		Human	PMID:15995708
Molecular Function	GO:0035716	chemokine (C-C motif) ligand 12 binding	Ccr2	IPI	UniProtKB:Q62401	Mouse	MGI:MGI:84964\|PMID:8996246
Molecular Function	GO:0035715	chemokine (C-C motif) ligand 2 binding	Ccr2	IPI	UniProtKB:P10148	Mouse	MGI:MGI:80507\|PMID:8662823
Molecular Function	GO:0035717	chemokine (C-C motif) ligand 7 binding	Ccr2	IPI	UniProtKB:Q03366	Mouse	MGI:MGI:80507\|PMID:8662823
Molecular Function	GO:0019955	cytokine binding	Ccr2	IPI	PR:P10148	Mouse	PMID:8631787
Molecular Function	GO:0042802	identical protein binding	Ccr2	IPI	RGD:620876	Rat	PMID:15978006\|RGD:1625372
Molecular Function	GO:0042802	identical protein binding	Ccr2	IPI	UniProtKB:O55193	Rat	PMID:15978006\|RGD:1625372
Molecular Function	GO:0005515	protein binding	CCR2	IPI	UniProtKB:Q8N104	Human	PMID:23938203
Molecular Function	GO:0005515	protein binding	Ccr2	IPI	PR:P10148	Mouse	PMID:8662823
Cellular Component	GO:0005737	cytoplasm	CCR2	IDA		Human	PMID:15995708
Cellular Component	GO:0005829	cytosol	Ccr2	IDA		Rat	PMID:15978006\|RGD:1625372
Cellular Component	GO:0030425	dendrite	Ccr2	IDA		Rat	PMID:15978006\|RGD:1625372
Cellular Component	GO:0030425	dendrite	Ccr2	IDA		Rat	PMID:18584881\|RGD:2303073
Cellular Component	GO:0009897	external side of plasma membrane	Ccr2	IDA		Mouse	PMID:23610400
Cellular Component	GO:0001650	fibrillar center	CCR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043025	neuronal cell body	Ccr2	IDA		Rat	PMID:15978006\|RGD:1625372
Cellular Component	GO:0043204	perikaryon	Ccr2	IDA		Rat	PMID:16196033\|RGD:1582321
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Ccr2	IDA		Rat	PMID:15978006\|RGD:1625372
Cellular Component	GO:0005886	plasma membrane	CCR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CCR2	IDA		Human	PMID:15995708
Cellular Component	GO:0005886	plasma membrane	CCR2	IDA		Human	PMID:18587271
Cellular Component	GO:0150001	primary dendrite	Ccr2	IDA		Rat	PMID:16196033\|RGD:1582321
Biological Process	GO:0001974	blood vessel remodeling	Ccr2	IEP		Rat	PMID:15178559\|RGD:1582349
Biological Process	GO:0006968	cellular defense response	Ccr2	IMP	MGI:MGI:2158213	Mouse	PMID:9366570
Biological Process	GO:0019725	cellular homeostasis	Ccr2	IDA		Mouse	MGI:MGI:3814510\|PMID:18832716
Biological Process	GO:0070098	chemokine-mediated signaling pathway	Ccr2	IDA		Mouse	MGI:MGI:80507\|PMID:8662823
Biological Process	GO:0070098	chemokine-mediated signaling pathway	Ccr2	IMP		Rat	PMID:18584881\|RGD:2303073
Biological Process	GO:0019221	cytokine-mediated signaling pathway	CCR2	IDA		Human	PMID:15995708
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Ccr2	IMP		Rat	PMID:16174730\|RGD:1625370
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Ccr2	IDA		Mouse	MGI:MGI:80507\|PMID:8662823
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Ccr2	IMP		Rat	PMID:18584881\|RGD:2303073
Biological Process	GO:0030097	hemopoiesis	Ccr2	IMP	MGI:MGI:2158213	Mouse	PMID:9366570
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Ccr2	IMP	MGI:MGI:2158345	Mouse	PMID:9342361
Biological Process	GO:0006959	humoral immune response	Ccr2	IMP	MGI:MGI:2158345	Mouse	PMID:10899907
Biological Process	GO:0006955	immune response	Ccr2	IMP	MGI:MGI:2158213	Mouse	PMID:10946288
Biological Process	GO:0006955	immune response	Ccr2	IMP	MGI:MGI:2158345	Mouse	PMID:10993920
Biological Process	GO:0006955	immune response	Ccr2	IMP	MGI:MGI:2158345	Mouse	PMID:10854218
Biological Process	GO:0006954	inflammatory response	Ccr2	IMP	MGI:MGI:2158213	Mouse	PMID:10946288
Biological Process	GO:0006954	inflammatory response	Ccr2	IDA		Rat	PMID:9655467\|RGD:632391
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	Ccr2	IEP		Rat	PMID:14674010\|RGD:1582346
Biological Process	GO:0090594	inflammatory response to wounding	Ccr2	IMP		Mouse	MGI:MGI:6155533\|PMID:29632244
Biological Process	GO:0090594	inflammatory response to wounding	Ccr2	IMP		Mouse	MGI:MGI:6274962\|PMID:24806994
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Ccr2	IDA		Rat	PMID:15978006\|RGD:1625372
Biological Process	GO:0061756	leukocyte adhesion to vascular endothelial cell	Ccr2	IMP	MGI:MGI:2158345	Mouse	PMID:9342361
Biological Process	GO:1905517	macrophage migration	Ccr2	IMP		Mouse	MGI:MGI:6274962\|PMID:24806994
Biological Process	GO:0042117	monocyte activation	ccr2	IMP	ZFIN:ZDB-MRPHLNO-171025-3	Zfish	PMID:28844797
Biological Process	GO:0002548	monocyte chemotaxis	Ccr2	IMP	MGI:MGI:5562913	Mouse	PMID:23913046
Biological Process	GO:0035696	monocyte extravasation	Ccr2	IMP		Mouse	MGI:MGI:6155533\|PMID:29632244
Biological Process	GO:0016525	negative regulation of angiogenesis	Ccr2	IMP		Mouse	MGI:MGI:3840068\|PMID:14566334
Biological Process	GO:0043310	negative regulation of eosinophil degranulation	Ccr2	IMP		Mouse	MGI:MGI:3699670\|PMID:14662900
Biological Process	GO:0002829	negative regulation of type 2 immune response	Ccr2	IMP		Mouse	MGI:MGI:3699670\|PMID:14662900
Biological Process	GO:0097350	neutrophil clearance	Ccr2	IMP	MGI:MGI:2158345	Mouse	PMID:9342361
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation	Ccr2	IMP		Mouse	MGI:MGI:3699670\|PMID:14662900
Biological Process	GO:2000464	positive regulation of astrocyte chemotaxis	CCR2	IDA		Human	PMID:12271471
Biological Process	GO:2000451	positive regulation of CD8-positive, alpha-beta T cell extravasation	Ccr2	IMP		Mouse	MGI:MGI:3699670\|PMID:14662900
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Ccr2	IMP		Mouse	MGI:MGI:5603000\|PMID:24906148
Biological Process	GO:2000473	positive regulation of hematopoietic stem cell migration	Ccr2	IMP		Mouse	MGI:MGI:4452272\|PMID:20234092
Biological Process	GO:0090265	positive regulation of immune complex clearance by monocytes and macrophages	Ccr2	IMP		Mouse	MGI:MGI:3840068\|PMID:14566334
Biological Process	GO:0050729	positive regulation of inflammatory response	Ccr2	IDA		Mouse	MGI:MGI:4452272\|PMID:20234092
Biological Process	GO:0032743	positive regulation of interleukin-2 production	Ccr2	IMP		Mouse	MGI:MGI:3699670\|PMID:14662900
Biological Process	GO:1903238	positive regulation of leukocyte tethering or rolling	Ccr2	IMP	MGI:MGI:2158345	Mouse	PMID:9342361
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	CCR2	IDA		Human	PMID:18587271
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	Ccr2	IMP		Mouse	MGI:MGI:3814510\|PMID:18832716
Biological Process	GO:2000439	positive regulation of monocyte extravasation	Ccr2	IMP		Mouse	MGI:MGI:3840068\|PMID:14566334
Biological Process	GO:1904783	positive regulation of NMDA glutamate receptor activity	Ccr2	IGI	UniProtKB:P01581,UniProtKB:P14844	Rat	PMID:27094552\|RGD:14397550
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	Ccr2	IDA		Rat	PMID:18584881\|RGD:2303073
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Ccr2	IMP		Mouse	MGI:MGI:6275444\|PMID:29993042
Biological Process	GO:0050870	positive regulation of T cell activation	Ccr2	IMP		Mouse	MGI:MGI:3699670\|PMID:14662900
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	Ccr2	IDA		Mouse	MGI:MGI:3812298\|PMID:18586982
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	Ccr2	IMP		Mouse	MGI:MGI:3759174\|PMID:10657654
Biological Process	GO:2000412	positive regulation of thymocyte migration	Ccr2	IMP		Mouse	MGI:MGI:6274970\|PMID:29930553
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ccr2	IMP		Mouse	MGI:MGI:3814510\|PMID:18832716
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ccr2	IMP		Rat	PMID:24826069\|RGD:8661667
Biological Process	GO:0032729	positive regulation of type II interferon production	Ccr2	IMP		Mouse	MGI:MGI:3699670\|PMID:14662900
Biological Process	GO:0050727	regulation of inflammatory response	Ccr2	IMP		Mouse	MGI:MGI:5926947\|PMID:28507030
Biological Process	GO:1905521	regulation of macrophage migration	Ccr2	IMP	MGI:MGI:2158345	Mouse	PMID:10854218
Biological Process	GO:0071675	regulation of mononuclear cell migration	Ccr2	IMP	MGI:MGI:2158345	Mouse	PMID:10993920
Biological Process	GO:0071675	regulation of mononuclear cell migration	Ccr2	IMP	MGI:MGI:2158345	Mouse	PMID:10899907
Biological Process	GO:0002724	regulation of T cell cytokine production	Ccr2	IMP		Mouse	MGI:MGI:5926947\|PMID:28507030
Biological Process	GO:0045580	regulation of T cell differentiation	Ccr2	IMP		Mouse	MGI:MGI:5926947\|PMID:28507030
Biological Process	GO:2000404	regulation of T cell migration	Ccr2	IMP	MGI:MGI:2158345	Mouse	PMID:10854218
Biological Process	GO:0010574	regulation of vascular endothelial growth factor production	Ccr2	IMP		Mouse	MGI:MGI:3840068\|PMID:14566334
Biological Process	GO:0055093	response to hyperoxia	Ccr2	IEP		Rat	PMID:21404274\|RGD:5130888
Biological Process	GO:0001666	response to hypoxia	Ccr2	IEP		Rat	PMID:18446360\|RGD:4144878
Biological Process	GO:0019233	sensory perception of pain	Ccr2	IMP		Mouse	MGI:MGI:6275444\|PMID:29993042
Biological Process	GO:0019233	sensory perception of pain	Ccr2	IMP	MGI:MGI:2158345	Mouse	PMID:12808141
Biological Process	GO:0035705	T-helper 17 cell chemotaxis	Ccr2	IDA		Mouse	MGI:MGI:3812298\|PMID:18586982

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.