Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ccr5

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CCR5
- Mouse genes Ccr5
- Rat genes Ccr5
- Zfish genes cabz01093075.1,ccr11.1,ccr2,ccr8.1,si:cabz01093077.1,si:ch211-207g17.3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccr5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	CCR5	IDA		Human	PMID:12421915
Molecular Function	GO:0019957	C-C chemokine binding	CCR5	IPI	UniProtKB:P13236	Human	PMID:10383387
Molecular Function	GO:0019957	C-C chemokine binding	CCR5	IPI	UniProtKB:P10147	Human	PMID:10679098
Molecular Function	GO:0019957	C-C chemokine binding	CCR5	IPI	UniProtKB:P13236	Human	PMID:10679098
Molecular Function	GO:0019957	C-C chemokine binding	CCR5	IPI	UniProtKB:P10147	Human	PMID:8699119
Molecular Function	GO:0019957	C-C chemokine binding	CCR5	IPI	UniProtKB:P13236	Human	PMID:8699119
Molecular Function	GO:0019957	C-C chemokine binding	CCR5	IPI	UniProtKB:P32246	Human	PMID:8699119
Molecular Function	GO:0019957	C-C chemokine binding	Ccr5	IPI	UniProtKB:P13501	Mouse	MGI:MGI:87663\|PMID:9139699
Molecular Function	GO:0016493	C-C chemokine receptor activity	CCR5	IDA		Human	PMID:10383387
Molecular Function	GO:0016493	C-C chemokine receptor activity	CCR5	IDA		Human	PMID:11278962
Molecular Function	GO:0016493	C-C chemokine receptor activity	CCR5	IDA		Human	PMID:8639485
Molecular Function	GO:0016493	C-C chemokine receptor activity	Ccr5	IDA		Mouse	PMID:8631787
Molecular Function	GO:0071791	chemokine (C-C motif) ligand 5 binding	CCR5	IPI	UniProtKB:P13501	Human	PMID:8699119
Molecular Function	GO:0042802	identical protein binding	CCR5	IPI	UniProtKB:P51681	Human	PMID:18230715
Molecular Function	GO:0042802	identical protein binding	CCR5	IPI	UniProtKB:P51681	Human	PMID:18632580
Molecular Function	GO:0042802	identical protein binding	CCR5	IPI	UniProtKB:P51681	Human	PMID:23121557
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:P01730	Human	PMID:10816381
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:P35579	Human	PMID:12421915
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:O43889-2	Human	PMID:15001559
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:P01730	Human	PMID:15660419
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:P61073	Human	PMID:15660419
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:Q16570-2	Human	PMID:18230715
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:P61073	Human	PMID:18632580
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:O54081	Human	PMID:23235831
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:P13501	Human	PMID:23480650
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:P13236:PRO_0000005165	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:Q9P003	Human	PMID:24405750
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:P13501	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:Q92583	Human	PMID:28381538
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:P01730	Human	PMID:30542158
Molecular Function	GO:0005515	protein binding	CCR5	IPI	UniProtKB:P54849	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Ccr5	IPI	RGD:3771\|RGD:3772	Rat	PMID:14674010\|RGD:1582346
Molecular Function	GO:0005515	protein binding	Ccr5	IPI	InterPro:IPR000777	Rat	PMID:16537566\|RGD:4890441
Molecular Function	GO:0005515	protein binding	Ccr5	IPI	RGD:3162	Rat	PMID:19559698\|RGD:4889986
Molecular Function	GO:0019901	protein kinase binding	Ccr5	IPI	RGD:69056	Rat	PMID:14674010\|RGD:1582346
Cellular Component	GO:0009986	cell surface	CCR5	IDA		Human	PMID:29739880
Cellular Component	GO:0009986	cell surface	CCR5	IDA		Human	PMID:10521508
Cellular Component	GO:0009986	cell surface	Ccr5	IDA		Mouse	PMID:23620790
Cellular Component	GO:0009986	cell surface	Ccr5	IDA		Rat	PMID:16320322\|RGD:4144893
Cellular Component	GO:0005737	cytoplasm	Ccr5	IDA		Rat	PMID:16320322\|RGD:4144893
Cellular Component	GO:0005768	endosome	CCR5	IDA		Human	PMID:10679098
Cellular Component	GO:0005768	endosome	Ccr5	IDA		Rat	PMID:12004163\|RGD:632389
Cellular Component	GO:0009897	external side of plasma membrane	CCR5	IDA		Human	PMID:10383387
Cellular Component	GO:0009897	external side of plasma membrane	CCR5	IDA		Human	PMID:10679098
Cellular Component	GO:0009897	external side of plasma membrane	CCR5	IDA		Human	PMID:11278962
Cellular Component	GO:0009897	external side of plasma membrane	CCR5	IDA		Human	PMID:19523456
Cellular Component	GO:0009897	external side of plasma membrane	Ccr5	IDA		Mouse	PMID:19008373
Cellular Component	GO:0009897	external side of plasma membrane	Ccr5	IDA		Mouse	PMID:16301745
Cellular Component	GO:0009897	external side of plasma membrane	Ccr5	IDA		Mouse	PMID:23610400
Biological Process	GO:0007568	aging	Ccr5	IEP		Rat	PMID:16369869\|RGD:2307163
Biological Process	GO:0006816	calcium ion transport	CCR5	IDA		Human	PMID:8699119
Biological Process	GO:0019722	calcium-mediated signaling	CCR5	IDA		Human	PMID:10679098
Biological Process	GO:0019722	calcium-mediated signaling	CCR5	IDA		Human	PMID:19523456
Biological Process	GO:0007267	cell-cell signaling	CCR5	IDA		Human	PMID:10679098
Biological Process	GO:0071222	cellular response to lipopolysaccharide	CCR5	IEP		Human	PMID:10679098
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Ccr5	IEP		Rat	PMID:23110133\|RGD:151665477
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Ccr5	IEP		Rat	PMID:23110133\|RGD:151665477
Biological Process	GO:0006952	defense response	Ccr5	IMP	MGI:MGI:1861911	Mouse	PMID:10528159
Biological Process	GO:0042742	defense response to bacterium	Ccr5	IEP		Rat	PMID:9670989\|RGD:632396
Biological Process	GO:0045444	fat cell differentiation	Ccr5	IEP		Rat	PMID:17286602\|RGD:2307036
Biological Process	GO:0030900	forebrain development	Ccr5	IEP		Rat	PMID:16516309\|RGD:4890442
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	CCR5	IMP		Human	PMID:19523456
Biological Process	GO:0006954	inflammatory response	Ccr5	IEP		Rat	PMID:12144807\|RGD:2303104
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	Ccr5	IEP		Rat	PMID:14674010\|RGD:1582346
Biological Process	GO:0000165	MAPK cascade	CCR5	IEP		Human	PMID:12032188
Biological Process	GO:0042117	monocyte activation	ccr2	IMP	ZFIN:ZDB-MRPHLNO-171025-3	Zfish	PMID:28844797
Biological Process	GO:0030517	negative regulation of axon extension	Ccr5	IMP		Rat	PMID:16537566\|RGD:4890441
Biological Process	GO:2000110	negative regulation of macrophage apoptotic process	Ccr5	IDA		Mouse	MGI:MGI:3608189\|PMID:16208318
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	Ccr5	IMP		Rat	PMID:20940264\|RGD:4889880
Biological Process	GO:0031343	positive regulation of cell killing	Ccr5	IMP		Rat	PMID:20940264\|RGD:4889880
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	Ccr5	IMP		Rat	PMID:16622027\|RGD:4890440
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Ccr5	IMP		Rat	PMID:23999490\|RGD:8552232
Biological Process	GO:0031622	positive regulation of fever generation	Ccr5	IMP		Rat	PMID:15066130\|RGD:2307192
Biological Process	GO:0010628	positive regulation of gene expression	Ccr5	IMP		Rat	PMID:19559698\|RGD:4889986
Biological Process	GO:0050729	positive regulation of inflammatory response	Ccr5	IMP		Rat	PMID:20940264\|RGD:4889880
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Ccr5	IMP		Rat	PMID:16790532\|RGD:1598562
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Ccr5	IMP		Rat	PMID:16790532\|RGD:1598562
Biological Process	GO:0045666	positive regulation of neuron differentiation	Ccr5	IMP		Rat	PMID:19559698\|RGD:4889986
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ccr5	IMP		Rat	PMID:16790532\|RGD:1598562
Biological Process	GO:0030334	regulation of cell migration	Ccr5	IMP		Rat	PMID:20940264\|RGD:4889880
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	CCR5	IDA		Human	PMID:19523456
Biological Process	GO:0070723	response to cholesterol	CCR5	IMP		Human	PMID:19523456
Biological Process	GO:0010212	response to ionizing radiation	Ccr5	IEP		Rat	PMID:16937495\|RGD:2298916
Biological Process	GO:0032496	response to lipopolysaccharide	Ccr5	IEP		Rat	PMID:19104678\|RGD:2306302
Biological Process	GO:0023052	signaling	CCR5	IEP		Human	PMID:12032188

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.