Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCR7
  • Mouse genes Ccr7
  • Rat genes Ccr7
  • Zfish genes ccr7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccr7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016493	C-C chemokine receptor activity	Ccr7	IMP	MGI:MGI:2180679	Mouse	PMID:10520991
Molecular Function	GO:0038117	C-C motif chemokine 19 receptor activity	CCR7	IDA		Human	PMID:9507024
Molecular Function	GO:0038121	C-C motif chemokine 21 receptor activity	CCR7	IDA		Human	PMID:9507024
Molecular Function	GO:0035757	chemokine (C-C motif) ligand 19 binding	CCR7	IPI	UniProtKB:O70460	Human	PMID:9507024
Molecular Function	GO:0035758	chemokine (C-C motif) ligand 21 binding	CCR7	IPI	UniProtKB:P84444	Human	PMID:9507024
Molecular Function	GO:0004930	G protein-coupled receptor activity	ccr7	IMP		Zfish	PMID:23055828
Molecular Function	GO:0005515	protein binding	Ccr7	IPI	UniProtKB:P20963	Mouse	MGI:MGI:5447878|PMID:22922463
Cellular Component	GO:0009986	cell surface	CCR7	IDA		Human	PMID:18308860
Cellular Component	GO:0009986	cell surface	Ccr7	IDA		Mouse	PMID:23620790
Cellular Component	GO:0009897	external side of plasma membrane	Ccr7	IDA		Mouse	PMID:19008373
Cellular Component	GO:0005739	mitochondrion	CCR7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CCR7	IDA		Human	PMID:21051556
Cellular Component	GO:0005886	plasma membrane	Ccr7	IDA		Mouse	MGI:MGI:4888468|PMID:21051556
Biological Process	GO:0071345	cellular response to cytokine stimulus	CCR7	IDA		Human	PMID:11602640
Biological Process	GO:0006935	chemotaxis	Ccr7	IMP	MGI:MGI:2180679	Mouse	PMID:10520991
Biological Process	GO:0009953	dorsal/ventral pattern formation	ccr7	IGI	ZFIN:ZDB-MRPHLNO-121213-1,ZFIN:ZDB-MRPHLNO-121213-2	Zfish	PMID:23055828
Biological Process	GO:0009953	dorsal/ventral pattern formation	ccr7	IMP	ZFIN:ZDB-MRPHLNO-121213-1	Zfish	PMID:23055828
Biological Process	GO:0048872	homeostasis of number of cells	Ccr7	IMP	MGI:MGI:3604543	Mouse	PMID:24069263
Biological Process	GO:0006955	immune response	Ccr7	IMP	MGI:MGI:2180679	Mouse	PMID:10520991
Biological Process	GO:0097029	mature conventional dendritic cell differentiation	Ccr7	IMP		Mouse	MGI:MGI:3576832|PMID:15845453
Biological Process	GO:0002408	myeloid dendritic cell chemotaxis	CCR7	IDA		Human	PMID:11602640
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ccr7	IGI	ZFIN:ZDB-GENE-060526-181	Zfish	PMID:23055828
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ccr7	IMP	ZFIN:ZDB-MRPHLNO-121213-1	Zfish	PMID:23055828
Biological Process	GO:0032695	negative regulation of interleukin-12 production	Ccr7	IMP		Mouse	MGI:MGI:4441559|PMID:20176793
Biological Process	GO:0045060	negative thymic T cell selection	Ccr7	IMP		Mouse	MGI:MGI:3847607|PMID:17785582
Biological Process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	Ccr7	IDA		Mouse	MGI:MGI:3576832|PMID:15845453
Biological Process	GO:2000510	positive regulation of dendritic cell chemotaxis	Ccr7	IMP		Mouse	MGI:MGI:1346262|PMID:10520991
Biological Process	GO:2000526	positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	Ccr7	IMP		Mouse	MGI:MGI:3576832|PMID:15845453
Biological Process	GO:0002922	positive regulation of humoral immune response	Ccr7	IMP		Mouse	MGI:MGI:1346262|PMID:10520991
Biological Process	GO:0002885	positive regulation of hypersensitivity	Ccr7	IMP		Mouse	MGI:MGI:1346262|PMID:10520991
Biological Process	GO:2000522	positive regulation of immunological synapse formation	Ccr7	IMP		Mouse	MGI:MGI:3576832|PMID:15845453
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Ccr7	IMP		Mouse	MGI:MGI:3576832|PMID:15845453
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	CCR7	IDA		Human	PMID:21051556
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	Ccr7	IMP		Mouse	MGI:MGI:4888468|PMID:21051556
Biological Process	GO:2000525	positive regulation of T cell costimulation	Ccr7	IMP		Mouse	MGI:MGI:3576832|PMID:15845453
Biological Process	GO:0050862	positive regulation of T cell receptor signaling pathway	Ccr7	IMP		Mouse	MGI:MGI:3847607|PMID:17785582
Biological Process	GO:0032651	regulation of interleukin-1 beta production	Ccr7	IMP		Mouse	MGI:MGI:4441559|PMID:20176793
Biological Process	GO:0032649	regulation of type II interferon production	Ccr7	IMP		Mouse	MGI:MGI:4441559|PMID:20176793
Biological Process	GO:0032496	response to lipopolysaccharide	Ccr7	IDA		Mouse	MGI:MGI:5285155|PMID:20638137

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern