Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCT4
  • Mouse genes Cct4
  • Rat genes Cct4
  • Zfish genes cct4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cct4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CCT4	IPI	UniProtKB:P17987	Human	PMID:16085932
Molecular Function	GO:0005515	protein binding	CCT4	IPI	UniProtKB:P78380	Human	PMID:24846140
Molecular Function	GO:0005515	protein binding	CCT4	IPI	UniProtKB:Q9BUR4	Human	PMID:25467444
Molecular Function	GO:0005515	protein binding	CCT4	IPI	UniProtKB:P17987	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	CCT4	IPI	UniProtKB:P78371	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	CCT4	IPI	UniProtKB:P51946	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCT4	IPI	UniProtKB:P78371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CCT4	IPI	UniProtKB:Q9Y238	Human	PMID:33144677
Molecular Function	GO:0005515	protein binding	Cct4	IPI	UniProtKB:Q8R368	Mouse	MGI:MGI:5544549|PMID:23872636
Molecular Function	GO:0044183	protein folding chaperone	CCT4	IDA		Human	PMID:30955883
Molecular Function	GO:0003723	RNA binding	CCT4	HDA		Human	PMID:22658674
Cellular Component	GO:0044297	cell body	Cct4	IDA		Mouse	PMID:21880732
Cellular Component	GO:0005813	centrosome	CCT4	IDA		Human	PMID:20080638
Cellular Component	GO:0005832	chaperonin-containing T-complex	CCT4	IPI		Human	PMID:22133715
Cellular Component	GO:0005832	chaperonin-containing T-complex	CCT4	IDA		Human	PMID:23011926
Cellular Component	GO:0005832	chaperonin-containing T-complex	CCT4	IDA		Human	PMID:30955883
Cellular Component	GO:0005832	chaperonin-containing T-complex	Cct4	IDA		Mouse	PMID:7953530
Cellular Component	GO:0005832	chaperonin-containing T-complex	Cct4	IDA		Mouse	PMID:7828721
Cellular Component	GO:0005829	cytosol	CCT4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	CCT4	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	CCT4	HDA		Human	PMID:23533145
Cellular Component	GO:0005874	microtubule	CCT4	IDA		Human	PMID:21525035
Cellular Component	GO:0005654	nucleoplasm	CCT4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0002199	zona pellucida receptor complex	Cct4	IDA		Mouse	PMID:21880732
Biological Process	GO:0007339	binding of sperm to zona pellucida	Cct4	IDA		Mouse	PMID:21880732
Biological Process	GO:0061077	chaperone-mediated protein folding	CCT4	IDA		Human	PMID:22133715
Biological Process	GO:1904851	positive regulation of establishment of protein localization to telomere	CCT4	IMP		Human	PMID:25467444
Biological Process	GO:1904871	positive regulation of protein localization to Cajal body	CCT4	HMP		Human	PMID:25467444
Biological Process	GO:0051973	positive regulation of telomerase activity	CCT4	IMP		Human	PMID:25467444
Biological Process	GO:1904874	positive regulation of telomerase RNA localization to Cajal body	CCT4	HMP		Human	PMID:25467444
Biological Process	GO:1904874	positive regulation of telomerase RNA localization to Cajal body	CCT4	IMP		Human	PMID:25467444
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	CCT4	IMP		Human	PMID:25467444
Biological Process	GO:0006457	protein folding	CCT4	IDA		Human	PMID:30955883
Biological Process	GO:0050821	protein stabilization	CCT4	IMP		Human	PMID:25467444
Biological Process	GO:0001666	response to hypoxia	cct4	IDA		Zfish	PMID:15994372
Biological Process	GO:0090666	scaRNA localization to Cajal body	CCT4	IMP		Human	PMID:25467444
Biological Process	GO:1901998	toxin transport	Cct4	IMP		Mouse	PMID:23716698

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern