Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD22
  • Mouse genes Cd22
  • Rat genes Cd22
  • Zfish genes si:dkey-24p1.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd22

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042609	CD4 receptor binding	Cd22	IPI	UniProtKB:P05540	Mouse	MGI:MGI:6202499|PMID:12115612
Molecular Function	GO:0005515	protein binding	CD22	IPI	UniProtKB:P19174	Human	PMID:8627166
Molecular Function	GO:0005515	protein binding	CD22	IPI	UniProtKB:P29350	Human	PMID:8627166
Molecular Function	GO:0005515	protein binding	CD22	IPI	UniProtKB:P43405	Human	PMID:8627166
Molecular Function	GO:0005515	protein binding	CD22	IPI	UniProtKB:P07948	Human	PMID:8647200
Molecular Function	GO:0005515	protein binding	CD22	IPI	UniProtKB:P43405	Human	PMID:8647200
Molecular Function	GO:0005515	protein binding	Cd22	IPI	UniProtKB:P29351|UniProtKB:Q60631	Mouse	MGI:MGI:2153585|PMID:11551923
Molecular Function	GO:0005515	protein binding	Cd22	IPI	UniProtKB:P29351	Mouse	MGI:MGI:5508302|PMID:9890995
Molecular Function	GO:0005515	protein binding	Cd22	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:3694163|PMID:10373493
Molecular Function	GO:0019903	protein phosphatase binding	Cd22	IPI	UniProtKB:P06800	Mouse	MGI:MGI:6202499|PMID:12115612
Molecular Function	GO:0033691	sialic acid binding	Cd22	IPI	CHEBI:62084	Mouse	MGI:MGI:6202499|PMID:12115612
Cellular Component	GO:0009986	cell surface	Cd22	IDA		Mouse	MGI:MGI:6201939|PMID:15095367
Cellular Component	GO:0005769	early endosome	CD22	IDA		Human	PMID:17562860
Cellular Component	GO:0009897	external side of plasma membrane	Cd22	IDA		Mouse	PMID:8418208
Cellular Component	GO:0070062	extracellular exosome	CD22	HDA		Human	PMID:20458337
Cellular Component	GO:0032809	neuronal cell body membrane	Cd22	IDA		Mouse	MGI:MGI:6201939|PMID:15095367
Cellular Component	GO:0005886	plasma membrane	Cd22	IPI	UniProtKB:P78324	Mouse	PMID:11606382
Cellular Component	GO:0055037	recycling endosome	CD22	IDA		Human	PMID:17562860
Biological Process	GO:0042113	B cell activation	CD22	IDA		Human	PMID:26017478
Biological Process	GO:0050859	negative regulation of B cell receptor signaling pathway	CD22	IMP		Human	PMID:24169826
Biological Process	GO:0050859	negative regulation of B cell receptor signaling pathway	CD22	IDA		Human	PMID:26017478
Biological Process	GO:0050849	negative regulation of calcium-mediated signaling	Cd22	IGI	UniProtKB:Q80ZE3	Mouse	MGI:MGI:4453395|PMID:20200274
Biological Process	GO:0002638	negative regulation of immunoglobulin production	Cd22	IGI	UniProtKB:Q80ZE3	Mouse	MGI:MGI:4453395|PMID:20200274
Biological Process	GO:0030888	regulation of B cell proliferation	Cd22	IGI	UniProtKB:Q80ZE3	Mouse	MGI:MGI:4453395|PMID:20200274
Biological Process	GO:0030100	regulation of endocytosis	CD22	IDA		Human	PMID:17562860
Biological Process	GO:0050776	regulation of immune response	Cd22	IGI	UniProtKB:Q80ZE3	Mouse	MGI:MGI:4453395|PMID:20200274

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern