Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD28
  • Mouse genes Cd28
  • Rat genes Cd28
  • Zfish genes si:dkey-1h24.6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd28

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Cd28	IPI	RGD:2299	Rat	PMID:7730618|RGD:2303155
Molecular Function	GO:0002020	protease binding	CD28	IPI	UniProtKB:P78325	Human	PMID:12777399
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P27986	Human	PMID:10820259
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P03406	Human	PMID:11285224
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P29965	Human	PMID:15067037
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P06239	Human	PMID:15554700
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P27986	Human	PMID:18641334
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P27986	Human	PMID:7568038
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P27986	Human	PMID:7584133
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P27986	Human	PMID:7807015
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P27986	Human	PMID:8146197
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P27986	Human	PMID:8183372
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P27986	Human	PMID:9417079
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P33681	Human	PMID:9784967
Molecular Function	GO:0005515	protein binding	CD28	IPI	UniProtKB:P42081	Human	PMID:9784967
Molecular Function	GO:0019901	protein kinase binding	Cd28	IPI	PR:P06240	Mouse	PMID:21245484
Cellular Component	GO:0009986	cell surface	CD28	IDA		Human	PMID:15067037
Cellular Component	GO:0009897	external side of plasma membrane	CD28	IDA		Human	PMID:11390434
Cellular Component	GO:0009897	external side of plasma membrane	Cd28	IDA		Mouse	PMID:23793062
Cellular Component	GO:0009897	external side of plasma membrane	Cd28	IDA		Mouse	PMID:8125140
Cellular Component	GO:0009897	external side of plasma membrane	Cd28	IDA		Mouse	PMID:7790813
Cellular Component	GO:0009897	external side of plasma membrane	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:7688139
Cellular Component	GO:0009897	external side of plasma membrane	Cd28	IDA		Mouse	PMID:12874832
Cellular Component	GO:0001772	immunological synapse	Cd28	IDA		Mouse	PMID:23793062
Cellular Component	GO:0045121	membrane raft	Cd28	IDA		Rat	PMID:15280538|RGD:1358463
Cellular Component	GO:0005886	plasma membrane	CD28	IDA		Human	PMID:11390434
Cellular Component	GO:0098636	protein complex involved in cell adhesion	CD28	IDA		Human	PMID:7544393
Biological Process	GO:0097190	apoptotic signaling pathway	Cd28	IDA		Mouse	PMID:10429671
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:9368605
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	Cd28	IDA		Mouse	PMID:14973438
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	Cd28	IDA		Mouse	PMID:8125140
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	Cd28	IDA		Mouse	PMID:9368605
Biological Process	GO:0032623	interleukin-2 production	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:7688139
Biological Process	GO:0010629	negative regulation of gene expression	CD28	IMP		Human	PMID:23817958
Biological Process	GO:0045060	negative thymic T cell selection	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:10429671
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	Cd28	IDA		Mouse	PMID:23589618
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	Cd28	IDA		Mouse	PMID:9368605
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	Cd28	IDA		Mouse	PMID:8125140
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	Cd28	IDA		Mouse	PMID:14973438
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:9368605
Biological Process	GO:0010628	positive regulation of gene expression	CD28	IMP		Human	PMID:23817958
Biological Process	GO:0002863	positive regulation of inflammatory response to antigenic stimulus	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:10791997
Biological Process	GO:0032733	positive regulation of interleukin-10 production	CD28	IDA		Human	PMID:8617933
Biological Process	GO:0032743	positive regulation of interleukin-2 production	CD28	IDA		Human	PMID:3875683
Biological Process	GO:0032743	positive regulation of interleukin-2 production	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:7688139
Biological Process	GO:0032753	positive regulation of interleukin-4 production	CD28	IDA		Human	PMID:8617933
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:7688139
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	CD28	IDA		Human	PMID:3159820
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Cd28	IDA		Mouse	PMID:23589618
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Cd28	IDA		Mouse	PMID:23589618
Biological Process	GO:0042102	positive regulation of T cell proliferation	CD28	IDA		Human	PMID:3159820
Biological Process	GO:0042102	positive regulation of T cell proliferation	CD28	IDA		Human	PMID:8617933
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd28	IDA		Mouse	PMID:12867038
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd28	IDA		Mouse	PMID:15240667
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:7688139
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd28	IDA		Mouse	PMID:12925852
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:10791997
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Cd28	IGI	MGI:MGI:1929913	Mouse	PMID:16809611
Biological Process	GO:0043491	protein kinase B signaling	Cd28	IDA		Mouse	PMID:23589618
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	Cd28	IGI	MGI:MGI:96756	Mouse	PMID:21245484
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	Cd28	IGI	MGI:MGI:98725	Mouse	PMID:21245484
Biological Process	GO:0045066	regulatory T cell differentiation	CD28	IDA		Human	PMID:18641304
Biological Process	GO:0042110	T cell activation	CD28	IGI	UniProtKB:P05112	Human	PMID:18337562
Biological Process	GO:0042110	T cell activation	CD28	IDA		Human	PMID:23918985
Biological Process	GO:0042110	T cell activation	Cd28	IMP		Rat	PMID:10458478|RGD:1625382
Biological Process	GO:0042110	T cell activation	Cd28	IMP		Rat	PMID:18357346|RGD:2303146
Biological Process	GO:0031295	T cell costimulation	Cd28	IDA		Mouse	PMID:9368605
Biological Process	GO:0031295	T cell costimulation	Cd28	IDA		Mouse	PMID:8125140
Biological Process	GO:0031295	T cell costimulation	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:9368605
Biological Process	GO:0031295	T cell costimulation	Cd28	IDA		Mouse	PMID:15240667
Biological Process	GO:0031295	T cell costimulation	Cd28	IGI	MGI:MGI:88332	Mouse	PMID:23793062
Biological Process	GO:0031295	T cell costimulation	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:7688139
Biological Process	GO:0031295	T cell costimulation	Cd28	IDA		Mouse	PMID:10429671
Biological Process	GO:0031295	T cell costimulation	Cd28	IDA		Mouse	PMID:12925852
Biological Process	GO:0031295	T cell costimulation	Cd28	IMP		Rat	PMID:7730618|RGD:2303155
Biological Process	GO:0042098	T cell proliferation	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:10791997
Biological Process	GO:0042098	T cell proliferation	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:7688139
Biological Process	GO:0042098	T cell proliferation	Cd28	IDA		Mouse	PMID:15240667
Biological Process	GO:0042098	T cell proliferation	Cd28	IDA		Mouse	PMID:12925852
Biological Process	GO:0050852	T cell receptor signaling pathway	Cd28	IMP	MGI:MGI:1857150	Mouse	PMID:23793062
Biological Process	GO:0006366	transcription by RNA polymerase II	Cd28	IGI	MGI:MGI:1929913	Mouse	PMID:16809611

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern