Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD33,SIGLEC6
  • Mouse genes Cd33
  • Rat genes Cd33
  • Zfish genes bckdhbl,si:dkey-24p1.7,zmp:0000000650
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd33

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SIGLEC6	IPI	UniProtKB:P15884	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SIGLEC6	IPI	UniProtKB:Q14192	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:P29350	Human	PMID:10206955
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q06124	Human	PMID:10206955
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:P29350	Human	PMID:10556798
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:P29350	Human	PMID:17947393
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q06124	Human	PMID:17947393
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:P06702	Human	PMID:24216507
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:P29350	Human	PMID:24216507
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:P02745	Human	PMID:28325905
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:O00767	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:O43169	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:O95393	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:P50402	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q07325	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q5BVD1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q92764	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q969X1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q96F15	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q9BU79	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q9H2S6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q9NS64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q9NV29	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q9UPZ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD33	IPI	UniProtKB:Q9Y5Z9	Human	PMID:32296183
Molecular Function	GO:0019903	protein phosphatase binding	CD33	IPI	UniProtKB:P29350	Human	PMID:10887109
Molecular Function	GO:0019903	protein phosphatase binding	CD33	IPI	UniProtKB:Q06124	Human	PMID:10887109
Molecular Function	GO:0033691	sialic acid binding	CD33	IMP		Human	PMID:15597323
Molecular Function	GO:0033691	sialic acid binding	CD33	IMP		Human	PMID:7718872
Cellular Component	GO:0005829	cytosol	SIGLEC6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	CD33	IDA		Human	PMID:20660734
Cellular Component	GO:0005794	Golgi apparatus	CD33	IDA		Human	PMID:21278227
Cellular Component	GO:0005654	nucleoplasm	CD33	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SIGLEC6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CD33	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CD33	IDA		Human	PMID:21278227
Biological Process	GO:0098609	cell-cell adhesion	CD33	IMP		Human	PMID:10206955
Biological Process	GO:0098609	cell-cell adhesion	CD33	IMP		Human	PMID:7718872
Biological Process	GO:0002765	immune response-inhibiting signal transduction	CD33	IDA		Human	PMID:10887109
Biological Process	GO:0051926	negative regulation of calcium ion transport	CD33	IMP		Human	PMID:10556798
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	CD33	IMP		Human	PMID:15597323
Biological Process	GO:0032717	negative regulation of interleukin-8 production	CD33	IMP		Human	PMID:15597323
Biological Process	GO:0150102	negative regulation of monocyte activation	CD33	IDA		Human	PMID:15597323
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	CD33	IMP		Human	PMID:15597323
Biological Process	GO:0050714	positive regulation of protein secretion	CD33	IMP		Human	PMID:27044754
Biological Process	GO:1903615	positive regulation of protein tyrosine phosphatase activity	CD33	IMP		Human	PMID:10556798

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern