Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD3E
  • Mouse genes Cd3e
  • Rat genes Cd3e
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd3e

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	CD3E	IDA		Human	PMID:14967045
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:P43403	Human	PMID:11855827
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:O43639	Human	PMID:17617578
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:P16333	Human	PMID:17617578
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:Q8TE68	Human	PMID:17617578
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:P13688	Human	PMID:18424730
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:Q8TE68	Human	PMID:18644376
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:P16333	Human	PMID:18955169
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:O43639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:O95159	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:Q08AM2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:Q12983	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:Q8N387	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:Q99640-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:P43403	Human	PMID:7761456
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:P43405	Human	PMID:7761456
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:P04234	Human	PMID:9485181
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:P09693	Human	PMID:9485181
Molecular Function	GO:0005515	protein binding	CD3E	IPI	UniProtKB:P43405	Human	PMID:9698567
Molecular Function	GO:0005515	protein binding	Cd3e	IPI	PR:P43404	Mouse	PMID:8196616
Molecular Function	GO:0005515	protein binding	Cd3e	IPI	PR:P39688	Mouse	PMID:8196616
Molecular Function	GO:0005515	protein binding	Cd3e	IPI	PR:P24161	Mouse	PMID:11390434
Molecular Function	GO:0017124	SH3 domain binding	CD3E	IPI	UniProtKB:O43639	Human	PMID:12110186
Molecular Function	GO:0017124	SH3 domain binding	CD3E	IPI	UniProtKB:P16333	Human	PMID:12110186
Cellular Component	GO:0042105	alpha-beta T cell receptor complex	CD3E	IPI		Human	PMID:31461748
Cellular Component	GO:0042105	alpha-beta T cell receptor complex	CD3E	IDA		Human	PMID:9485181
Cellular Component	GO:0042105	alpha-beta T cell receptor complex	Cd3e	IDA		Mouse	PMID:9064344
Cellular Component	GO:0042105	alpha-beta T cell receptor complex	Cd3e	IDA		Mouse	PMID:9208839
Cellular Component	GO:0044297	cell body	Cd3e	IDA		Mouse	MGI:MGI:3718938|PMID:17502348
Cellular Component	GO:0005911	cell-cell junction	Cd3e	IDA		Mouse	PMID:23793062
Cellular Component	GO:0043197	dendritic spine	Cd3e	IDA		Mouse	MGI:MGI:3718938|PMID:17502348
Cellular Component	GO:0005783	endoplasmic reticulum	CD3E	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	CD3E	IDA		Human	PMID:11390434
Cellular Component	GO:0009897	external side of plasma membrane	CD3E	IDA		Human	PMID:17213291
Cellular Component	GO:0009897	external side of plasma membrane	Cd3e	IDA		Mouse	PMID:15368291
Cellular Component	GO:0009897	external side of plasma membrane	Cd3e	IDA		Mouse	PMID:17277142
Cellular Component	GO:0009897	external side of plasma membrane	Cd3e	IDA		Mouse	PMID:7630421
Cellular Component	GO:0009897	external side of plasma membrane	Cd3e	IDA		Mouse	PMID:8125140
Cellular Component	GO:0009897	external side of plasma membrane	Cd3e	IDA		Mouse	PMID:10072077
Cellular Component	GO:0009897	external side of plasma membrane	Cd3e	IDA		Mouse	PMID:20660734
Cellular Component	GO:0009897	external side of plasma membrane	Cd3e	IDA		Mouse	PMID:8755570
Cellular Component	GO:0009897	external side of plasma membrane	Cd3e	IDA		Mouse	PMID:10485657
Cellular Component	GO:0009897	external side of plasma membrane	Cd3e	IDA		Mouse	PMID:22732588
Cellular Component	GO:0009897	external side of plasma membrane	Cd3e	IDA		Mouse	PMID:19838199
Cellular Component	GO:0009897	external side of plasma membrane	Cd3e	IDA		Mouse	PMID:20709950
Cellular Component	GO:0009897	external side of plasma membrane	Cd3e	IDA		Mouse	PMID:8666928
Cellular Component	GO:0005794	Golgi apparatus	CD3E	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001772	immunological synapse	Cd3e	IDA		Mouse	PMID:14635057
Cellular Component	GO:0001772	immunological synapse	Cd3e	IDA		Mouse	PMID:15064761
Cellular Component	GO:0005886	plasma membrane	CD3E	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CD3E	IDA		Human	PMID:11390434
Cellular Component	GO:0005886	plasma membrane	Cd3e	IDA		Mouse	MGI:MGI:3718938|PMID:17502348
Cellular Component	GO:0042101	T cell receptor complex	CD3E	IDA		Human	PMID:8176201
Biological Process	GO:0097190	apoptotic signaling pathway	Cd3e	IDA		Mouse	PMID:8666928
Biological Process	GO:0019722	calcium-mediated signaling	Cd3e	IDA		Mouse	PMID:7630421
Biological Process	GO:0019722	calcium-mediated signaling	Cd3e	IDA		Mouse	PMID:8943715
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	Cd3e	IDA		Mouse	PMID:8125140
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	Cd3e	IDA		Mouse	PMID:11894097
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	Cd3e	IDA		Mouse	PMID:14973438
Biological Process	GO:0007166	cell surface receptor signaling pathway	Cd3e	IDA		Mouse	PMID:8943715
Biological Process	GO:0007166	cell surface receptor signaling pathway	Cd3e	IDA		Mouse	PMID:7630421
Biological Process	GO:0021549	cerebellum development	Cd3e	IMP		Mouse	MGI:MGI:3718938|PMID:17502348
Biological Process	GO:0016358	dendrite development	Cd3e	IMP		Mouse	MGI:MGI:3718938|PMID:17502348
Biological Process	GO:0032633	interleukin-4 production	Cd3e	IDA		Mouse	PMID:11894097
Biological Process	GO:0046649	lymphocyte activation	Cd3e	IMP		Mouse	PMID:15843560
Biological Process	GO:0010629	negative regulation of gene expression	CD3E	IMP		Human	PMID:23817958
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Cd3e	IDA		Mouse	PMID:10981962
Biological Process	GO:0045060	negative thymic T cell selection	Cd3e	IDA		Mouse	PMID:7630421
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Cd3e	IDA		Mouse	PMID:10485657
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	Cd3e	IDA		Mouse	PMID:8943715
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	Cd3e	IDA		Mouse	PMID:7630421
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	Cd3e	IDA		Mouse	PMID:8125140
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	Cd3e	IDA		Mouse	PMID:11894097
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	Cd3e	IDA		Mouse	PMID:14973438
Biological Process	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin	Cd3e	IGI	UniProtKB:P24063,UniProtKB:Q86WV1	Mouse	MGI:MGI:6201899|PMID:12652296
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	Cd3e	IGI	UniProtKB:Q86WV1	Mouse	MGI:MGI:6201899|PMID:12652296
Biological Process	GO:0010628	positive regulation of gene expression	CD3E	IMP		Human	PMID:23817958
Biological Process	GO:0032743	positive regulation of interleukin-2 production	Cd3e	IDA		Mouse	PMID:12874832
Biological Process	GO:0032753	positive regulation of interleukin-4 production	Cd3e	IDA		Mouse	PMID:11894097
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Cd3e	IDA		Mouse	PMID:10485657
Biological Process	GO:0050870	positive regulation of T cell activation	Cd3e	IDA		Mouse	PMID:12874832
Biological Process	GO:0002669	positive regulation of T cell anergy	Cd3e	IDA		Mouse	PMID:14973438
Biological Process	GO:0042102	positive regulation of T cell proliferation	CD3E	IMP		Human	PMID:12110186
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd3e	IDA		Mouse	PMID:15368291
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd3e	IDA		Mouse	PMID:10485657
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd3e	IDA		Mouse	PMID:12874832
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd3e	IDA		Mouse	PMID:10072077
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd3e	IDA		Rat	PMID:10498748|RGD:1600792
Biological Process	GO:0032729	positive regulation of type II interferon production	Cd3e	IDA		Mouse	PMID:11894097
Biological Process	GO:0007584	response to nutrient	Cd3e	IDA		Rat	PMID:10498748|RGD:1600792
Biological Process	GO:0007224	smoothened signaling pathway	Cd3e	IDA		Mouse	PMID:10981962
Biological Process	GO:0042110	T cell activation	Cd3e	IDA		Mouse	PMID:12874832
Biological Process	GO:0002870	T cell anergy	Cd3e	IDA		Mouse	PMID:14973438
Biological Process	GO:0031295	T cell costimulation	Cd3e	IGI	MGI:MGI:88327	Mouse	PMID:23793062
Biological Process	GO:0033077	T cell differentiation in thymus	Cd3e	IEP		Rat	PMID:11896936|RGD:2313407
Biological Process	GO:0042098	T cell proliferation	Cd3e	IDA		Mouse	PMID:12874832
Biological Process	GO:0042098	T cell proliferation	Cd3e	IDA		Mouse	PMID:10072077
Biological Process	GO:0042098	T cell proliferation	Cd3e	IDA		Mouse	PMID:10485657
Biological Process	GO:0042098	T cell proliferation	Cd3e	IDA		Mouse	PMID:15368291
Biological Process	GO:0050852	T cell receptor signaling pathway	Cd3e	IDA		Mouse	PMID:10485657
Biological Process	GO:0032609	type II interferon production	Cd3e	IDA		Mouse	PMID:11894097

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern