Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD4
  • Mouse genes Cd4
  • Rat genes Cd4
  • Zfish genes cd4-1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	CD4	IPI	UniProtKB:O15162	Human	PMID:19333378
Molecular Function	GO:0042802	identical protein binding	CD4	IPI	UniProtKB:P01730	Human	PMID:9168119
Molecular Function	GO:0019865	immunoglobulin binding	Cd4	IDA		Rat	PMID:2338715|RGD:10058950
Molecular Function	GO:0042011	interleukin-16 binding	CD4	IPI	UniProtKB:Q14005	Human	PMID:24942581
Molecular Function	GO:0042012	interleukin-16 receptor activity	CD4	IDA		Human	PMID:24942581
Molecular Function	GO:0008289	lipid binding	CD4	EXP		Human	PMID:19781520
Molecular Function	GO:0008289	lipid binding	CD4	EXP		Human	PMID:9622505
Molecular Function	GO:0042289	MHC class II protein binding	CD4	IDA		Human	PMID:11535811
Molecular Function	GO:0042289	MHC class II protein binding	CD4	IPI	UniProtKB:P04233,UniProtKB:P01911	Human	PMID:24942581
Molecular Function	GO:0042289	MHC class II protein binding	CD4	IDA		Human	PMID:2823150
Molecular Function	GO:0023026	MHC class II protein complex binding	CD4	IDA		Human	PMID:27114505
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P51681	Human	PMID:10816381
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P03375	Human	PMID:10922058
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:Q9NZD8	Human	PMID:11113139
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P03407	Human	PMID:11264384
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P51681	Human	PMID:15660419
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P04150	Human	PMID:16888650
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P06239	Human	PMID:16888650
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P06239	Human	PMID:17005671
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P04578:PRO_0000038427	Human	PMID:17301785
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:Q9NRQ2	Human	PMID:19333378
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P04578	Human	PMID:20080564
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:Q1PHM6	Human	PMID:20357769
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P05919	Human	PMID:23890821
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:Q2N0S6	Human	PMID:26098315
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P01903	Human	PMID:27114505
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P01911	Human	PMID:27114505
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P51681	Human	PMID:30542158
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:Q9Y371	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P03406	Human	PMID:7831289
Molecular Function	GO:0005515	protein binding	CD4	IPI	UniProtKB:P60033	Human	PMID:9168119
Molecular Function	GO:0005515	protein binding	Cd4	IPI	UniProtKB:P06240	Mouse	MGI:MGI:3690806|PMID:7664803
Molecular Function	GO:0005515	protein binding	Cd4	IPI	UniProtKB:P06240	Mouse	MGI:MGI:5532887|PMID:24034254
Molecular Function	GO:0005515	protein binding	Cd4	IPI	UniProtKB:P06240	Mouse	MGI:MGI:4839467|PMID:7486703
Molecular Function	GO:0042803	protein homodimerization activity	CD4	IDA		Human	PMID:12444132
Molecular Function	GO:0042803	protein homodimerization activity	CD4	IDA		Human	PMID:9168119
Molecular Function	GO:0019901	protein kinase binding	CD4	IPI	UniProtKB:P06239	Human	PMID:7486703
Molecular Function	GO:0019901	protein kinase binding	Cd4	IPI	RGD:2641	Rat	PMID:1372996|RGD:2324896
Molecular Function	GO:1990782	protein tyrosine kinase binding	CD4	IPI	UniProtKB:P06240	Human	PMID:3262426
Molecular Function	GO:1990782	protein tyrosine kinase binding	Cd4	IDA		Rat	PMID:8959663|RGD:10058973
Molecular Function	GO:0005102	signaling receptor binding	Cd4	IPI	UniProtKB:P35329	Rat	PMID:12115612|RGD:13792543
Molecular Function	GO:0008270	zinc ion binding	CD4	IDA		Human	PMID:9668045
Cellular Component	GO:0009986	cell surface	Cd4	IDA		Mouse	PMID:8612131
Cellular Component	GO:0009986	cell surface	Cd4	IDA		Rat	PMID:15474526|RGD:151665813
Cellular Component	GO:0009986	cell surface	cd4-1	IDA		Zfish	PMID:26083432
Cellular Component	GO:0005788	endoplasmic reticulum lumen	Cd4	IDA		Mouse	PMID:16223484
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Cd4	IDA		Mouse	PMID:16223484
Cellular Component	GO:0009897	external side of plasma membrane	CD4	IDA		Human	PMID:17213291
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:9133426
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:21508411
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:10943842
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:8524870
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:15843532
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:21460847
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:8788039
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:18776904
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:20706986
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:16287714
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:7630421
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:12421911
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:19934022
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:15728238
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:15322158
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:17082577
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:18836449
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:10072077
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:19349303
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:16973387
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:7589135
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:14609575
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:15368291
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:10704459
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:7477352
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:17357106
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:19723499
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:15795238
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:19008373
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:7688139
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:16455951
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:22072979
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:7477353
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:9208839
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:8755570
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:8769481
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:19838199
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:18641307
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:20709950
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Mouse	PMID:20399120
Cellular Component	GO:0009897	external side of plasma membrane	Cd4	IDA		Rat	PMID:3159821|RGD:10058955
Cellular Component	GO:0045121	membrane raft	CD4	IDA		Human	PMID:9168119
Cellular Component	GO:0045121	membrane raft	Cd4	IDA		Mouse	PMID:15128768
Cellular Component	GO:0005886	plasma membrane	CD4	IDA		Human	PMID:11390434
Cellular Component	GO:0005886	plasma membrane	CD4	IDA		Human	PMID:19333378
Cellular Component	GO:0005886	plasma membrane	CD4	IDA		Human	PMID:24942581
Cellular Component	GO:0005886	plasma membrane	CD4	IDA		Human	PMID:2823150
Cellular Component	GO:0005886	plasma membrane	CD4	IDA		Human	PMID:8124721
Cellular Component	GO:0005886	plasma membrane	Cd4	IDA		Mouse	MGI:MGI:5693239|PMID:3262426
Cellular Component	GO:0005886	plasma membrane	Cd4	IDA		Mouse	PMID:14517216
Cellular Component	GO:0005886	plasma membrane	Cd4	IDA		Rat	PMID:3104900|RGD:1299836
Biological Process	GO:0019722	calcium-mediated signaling	Cd4	IDA		Mouse	PMID:9208839
Biological Process	GO:0007166	cell surface receptor signaling pathway	Cd4	IDA		Mouse	MGI:MGI:5693238|PMID:2784195
Biological Process	GO:0007166	cell surface receptor signaling pathway	Cd4	IDA		Mouse	PMID:9208839
Biological Process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	CD4	IDA		Human	PMID:24942581
Biological Process	GO:0001816	cytokine production	Cd4	IGI	MGI:MGI:1891436	Mouse	PMID:7930593
Biological Process	GO:0001816	cytokine production	Cd4	IMP	MGI:MGI:1857281	Mouse	PMID:7930593
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Cd4	IMP	MGI:MGI:1857281	Mouse	PMID:14688352
Biological Process	GO:0035397	helper T cell enhancement of adaptive immune response	Cd4	IMP		Mouse	MGI:MGI:1933768|PMID:1832488
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	CD4	IDA		Human	PMID:24942581
Biological Process	GO:0030225	macrophage differentiation	CD4	IMP		Human	PMID:24942581
Biological Process	GO:0032507	maintenance of protein location in cell	CD4	IDA		Human	PMID:15128768
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Cd4	IDA		Mouse	PMID:9208839
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	Cd4	IDA		Rat	PMID:8959663|RGD:10058973
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	Cd4	IDA		Mouse	PMID:9208839
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CD4	IDA		Human	PMID:24942581
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	CD4	IDA		Human	PMID:24942581
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	CD4	IDA		Human	PMID:24942581
Biological Process	GO:0033674	positive regulation of kinase activity	CD4	IDA		Human	PMID:24942581
Biological Process	GO:0043410	positive regulation of MAPK cascade	CD4	IDA		Human	PMID:24942581
Biological Process	GO:0045657	positive regulation of monocyte differentiation	CD4	IDA		Human	PMID:24942581
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Cd4	IDA		Mouse	PMID:9208839
Biological Process	GO:0045860	positive regulation of protein kinase activity	CD4	IDA		Human	PMID:2118992
Biological Process	GO:0001934	positive regulation of protein phosphorylation	CD4	IDA		Human	PMID:24942581
Biological Process	GO:0050870	positive regulation of T cell activation	Cd4	IDA		Mouse	PMID:12421911
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd4	IMP		Rat	PMID:15000837|RGD:10058971
Biological Process	GO:0046598	positive regulation of viral entry into host cell	CD4	IDA		Human	PMID:24942581
Biological Process	GO:0051924	regulation of calcium ion transport	CD4	IDA		Human	PMID:24942581
Biological Process	GO:0050863	regulation of T cell activation	CD4	IDA		Human	PMID:1533274
Biological Process	GO:0032355	response to estradiol	Cd4	IEP		Rat	PMID:2478646|RGD:10059316
Biological Process	GO:0033280	response to vitamin D	Cd4	IEP		Rat	PMID:8759780|RGD:10058969
Biological Process	GO:0042110	T cell activation	Cd4	IDA		Mouse	PMID:12421911
Biological Process	GO:0042110	T cell activation	Cd4	IMP		Rat	PMID:10458478|RGD:1625382
Biological Process	GO:0030217	T cell differentiation	CD4	IDA		Human	PMID:1533274
Biological Process	GO:0045058	T cell selection	CD4	IDA		Human	PMID:9551897

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern