Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD40
  • Mouse genes Cd40
  • Rat genes Cd40
  • Zfish genes cd40
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd40

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003823	antigen binding	Cd40	IDA		Rat	PMID:22355605|RGD:7248752
Molecular Function	GO:0042615	CD154 receptor binding	cd40	IDA		Zfish	PMID:19494299
Molecular Function	GO:0019899	enzyme binding	CD40	IPI	UniProtKB:P08246	Human	PMID:12223522
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q12933	Human	PMID:10518213
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q9Y4K3	Human	PMID:12140561
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q12933	Human	PMID:20676093
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q9Y4K3	Human	PMID:20676093
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:B2RUR8	Human	PMID:23334419
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q12933	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q12933	Human	PMID:25502805
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q12933	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:P27986	Human	PMID:26210919
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:P29965	Human	PMID:31331973
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q12933	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:P21145	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:P30301	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:P30825	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:P60201-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q12933	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q5BJH2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q5J5C9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q6N075	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q6UX40	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q8NBI2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q96CP7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q96DZ9-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q96H72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q99726	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q9BRI3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q9BVK8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q9NX76	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q9Y5U4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:Q13114	Human	PMID:7527023
Molecular Function	GO:0005515	protein binding	CD40	IPI	UniProtKB:P29965	Human	PMID:9468137
Molecular Function	GO:0005515	protein binding	Cd40	IPI	UniProtKB:P39429	Mouse	MGI:MGI:4462284|PMID:20614026
Molecular Function	GO:0005515	protein binding	Cd40	IPI	UniProtKB:P35991	Mouse	MGI:MGI:5002402|PMID:21441935
Molecular Function	GO:0005515	protein binding	Cd40	IPI	UniProtKB:P39429	Mouse	MGI:MGI:5474156|PMID:23334419
Molecular Function	GO:0005515	protein binding	Cd40	IPI	UniProtKB:P39429	Mouse	MGI:MGI:5915881|PMID:17919601
Molecular Function	GO:0005515	protein binding	Cd40	IPI	UniProtKB:P70196	Mouse	MGI:MGI:84147|PMID:8910514
Molecular Function	GO:0019904	protein domain specific binding	Cd40	IPI	UniProtKB:Q04968	Rat	PMID:25260678|RGD:11344975
Molecular Function	GO:0031625	ubiquitin protein ligase binding	CD40	IPI	UniProtKB:O94972	Human	PMID:11279055
Molecular Function	GO:0031625	ubiquitin protein ligase binding	CD40	IPI	UniProtKB:Q12933	Human	PMID:11279055
Cellular Component	GO:0035631	CD40 receptor complex	Cd40	IDA		Mouse	MGI:MGI:4462284|PMID:20614026
Cellular Component	GO:0009986	cell surface	CD40	HDA		Human	PMID:23981064
Cellular Component	GO:0009986	cell surface	Cd40	IDA		Mouse	PMID:20685650
Cellular Component	GO:0009986	cell surface	Cd40	IDA		Rat	PMID:15069176|RGD:8547784
Cellular Component	GO:0009986	cell surface	Cd40	IDA		Rat	PMID:21094836|RGD:5490976
Cellular Component	GO:0005737	cytoplasm	Cd40	IDA		Rat	PMID:23125417|RGD:7248751
Cellular Component	GO:0009897	external side of plasma membrane	Cd40	IDA		Mouse	PMID:15240714
Cellular Component	GO:0009897	external side of plasma membrane	Cd40	IDA		Mouse	PMID:10979977
Cellular Component	GO:0009897	external side of plasma membrane	Cd40	IDA		Mouse	PMID:8566034
Cellular Component	GO:0009897	external side of plasma membrane	Cd40	IDA		Mouse	PMID:14560001
Cellular Component	GO:0009897	external side of plasma membrane	Cd40	IDA		Mouse	PMID:17277142
Cellular Component	GO:0009897	external side of plasma membrane	Cd40	IDA		Mouse	PMID:18684012
Cellular Component	GO:0009897	external side of plasma membrane	cd40	IDA		Zfish	PMID:19494299
Cellular Component	GO:0070062	extracellular exosome	CD40	HDA		Human	PMID:20458337
Cellular Component	GO:0005615	extracellular space	Cd40	IDA		Rat	PMID:16716410|RGD:2313422
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cd40	IDA		Mouse	PMID:16708399
Cellular Component	GO:0043025	neuronal cell body	Cd40	IDA		Rat	PMID:25972624|RGD:11344972
Cellular Component	GO:0005886	plasma membrane	Cd40	IDA		Mouse	MGI:MGI:4462284|PMID:20614026
Cellular Component	GO:0043196	varicosity	Cd40	IDA		Rat	PMID:25972624|RGD:11344972
Biological Process	GO:0042113	B cell activation	Cd40	IDA		Mouse	PMID:16546095
Biological Process	GO:0042113	B cell activation	Cd40	IDA		Mouse	PMID:14594818
Biological Process	GO:0042113	B cell activation	Cd40	IMP		Rat	PMID:27692815|RGD:14398462
Biological Process	GO:0019724	B cell mediated immunity	Cd40	IGI	MGI:MGI:88336	Mouse	PMID:18624351
Biological Process	GO:0019724	B cell mediated immunity	Cd40	IGI	MGI:MGI:2143599	Mouse	PMID:18624351
Biological Process	GO:0042100	B cell proliferation	Cd40	IDA		Mouse	PMID:11894097
Biological Process	GO:0042100	B cell proliferation	Cd40	IDA		Mouse	PMID:8666928
Biological Process	GO:0042100	B cell proliferation	Cd40	IDA		Mouse	PMID:10979977
Biological Process	GO:0042100	B cell proliferation	Cd40	IDA		Mouse	PMID:14607964
Biological Process	GO:0042100	B cell proliferation	Cd40	IGI	MGI:MGI:87891	Mouse	PMID:15963492
Biological Process	GO:0042100	B cell proliferation	Cd40	IDA		Mouse	PMID:8920854
Biological Process	GO:0023035	CD40 signaling pathway	CD40	IDA		Human	PMID:31331973
Biological Process	GO:0023035	CD40 signaling pathway	Cd40	IGI	MGI:MGI:2143599	Mouse	PMID:18624351
Biological Process	GO:0036018	cellular response to erythropoietin	Cd40	IEP		Rat	PMID:21649646|RGD:10401062
Biological Process	GO:0071347	cellular response to interleukin-1	Cd40	IEP		Rat	PMID:10403401|RGD:634252
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cd40	IEP		Rat	PMID:19271152|RGD:5491178
Biological Process	GO:0071260	cellular response to mechanical stimulus	CD40	IEP		Human	PMID:19593445
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Cd40	IEP		Rat	PMID:10403401|RGD:634252
Biological Process	GO:0042832	defense response to protozoan	Cd40	IDA		Mouse	PMID:19047410
Biological Process	GO:0051607	defense response to virus	Cd40	IDA		Mouse	PMID:17277142
Biological Process	GO:0002768	immune response-regulating cell surface receptor signaling pathway	Cd40	IDA		Mouse	PMID:15240714
Biological Process	GO:0002377	immunoglobulin production	Cd40	IGI	MGI:MGI:2143599	Mouse	PMID:18624351
Biological Process	GO:0002377	immunoglobulin production	Cd40	IGI	MGI:MGI:88336	Mouse	PMID:18624351
Biological Process	GO:0006954	inflammatory response	Cd40	IEP		Rat	PMID:10403401|RGD:634252
Biological Process	GO:0006954	inflammatory response	Cd40	IMP		Rat	PMID:15591506|RGD:5508169
Biological Process	GO:0032615	interleukin-12 production	Cd40	IDA		Mouse	PMID:15240714
Biological Process	GO:0006874	intracellular calcium ion homeostasis	CD40	IMP		Human	PMID:21410936
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Cd40	IMP		Mouse	MGI:MGI:5306543|PMID:21410936
Biological Process	GO:0045766	positive regulation of angiogenesis	CD40	IMP		Human	PMID:28566713
Biological Process	GO:0030890	positive regulation of B cell proliferation	Cd40	IDA		Mouse	PMID:14607964
Biological Process	GO:0030890	positive regulation of B cell proliferation	Cd40	IDA		Mouse	PMID:8666928
Biological Process	GO:0030890	positive regulation of B cell proliferation	Cd40	IDA		Mouse	PMID:8920854
Biological Process	GO:0030890	positive regulation of B cell proliferation	Cd40	IDA		Mouse	PMID:11894097
Biological Process	GO:0030890	positive regulation of B cell proliferation	Cd40	IGI	MGI:MGI:87891	Mouse	PMID:15963492
Biological Process	GO:0030890	positive regulation of B cell proliferation	Cd40	IDA		Mouse	PMID:10979977
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	CD40	IMP		Human	PMID:28566713
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	CD40	IDA		Human	PMID:12885753
Biological Process	GO:0043547	positive regulation of GTPase activity	CD40	IMP		Human	PMID:21410936
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	CD40	IEP		Human	PMID:12761501
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Cd40	IDA		Mouse	PMID:15240714
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	Cd40	IDA		Mouse	PMID:12882831
Biological Process	GO:0043406	positive regulation of MAP kinase activity	CD40	IMP		Human	PMID:21410936
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	CD40	IMP		Human	PMID:21410936
Biological Process	GO:0090037	positive regulation of protein kinase C signaling	CD40	IMP		Human	PMID:21410936
Biological Process	GO:0001934	positive regulation of protein phosphorylation	CD40	IMP		Human	PMID:21410936
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	CD40	IMP		Human	PMID:21410936
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	CD40	IMP		Human	PMID:21410936
Biological Process	GO:0043491	protein kinase B signaling	Cd40	IDA		Mouse	PMID:16546095
Biological Process	GO:0050776	regulation of immune response	Cd40	IDA		Mouse	PMID:12882831
Biological Process	GO:0002637	regulation of immunoglobulin production	Cd40	IDA		Mouse	PMID:12958312
Biological Process	GO:0009617	response to bacterium	Cd40	IEP		Rat	PMID:22355605|RGD:7248752
Biological Process	GO:0033590	response to cobalamin	Cd40	IEP		Rat	PMID:16716410|RGD:2313422
Biological Process	GO:0031667	response to nutrient levels	Cd40	IEP		Rat	PMID:21840190|RGD:11352660
Biological Process	GO:1901652	response to peptide	Cd40	IEP		Rat	PMID:19457161|RGD:11352679
Biological Process	GO:0034341	response to type II interferon	Cd40	IEP		Rat	PMID:10403401|RGD:634252
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	cd40	IMP	ZFIN:ZDB-MRPHLNO-120914-1	Zfish	PMID:22345667

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern