Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD40LG
  • Mouse genes Cd40lg
  • Rat genes Cd40lg
  • Zfish genes cd40lg
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd40lg

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005174	CD40 receptor binding	CD40LG	IMP		Human	PMID:31331973
Molecular Function	GO:0005174	CD40 receptor binding	CD40LG	IPI	UniProtKB:P25942	Human	PMID:9468137
Molecular Function	GO:0005174	CD40 receptor binding	Cd40lg	IPI	RGD:1604657	Rat	PMID:18262271|RGD:2313421
Molecular Function	GO:0005174	CD40 receptor binding	cd40lg	IDA		Zfish	PMID:19494299
Molecular Function	GO:0005178	integrin binding	CD40LG	IMP		Human	PMID:31331973
Molecular Function	GO:0005515	protein binding	CD40LG	IPI	UniProtKB:P10747	Human	PMID:15067037
Molecular Function	GO:0005515	protein binding	CD40LG	IPI	UniProtKB:P05106,UniProtKB:P06756	Human	PMID:31331973
Molecular Function	GO:0005515	protein binding	CD40LG	IPI	UniProtKB:P05556,UniProtKB:P08648	Human	PMID:31331973
Molecular Function	GO:0005515	protein binding	CD40LG	IPI	UniProtKB:P25942	Human	PMID:31331973
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	CD40LG	IDA		Human	PMID:15067037
Cellular Component	GO:0044297	cell body	Cd40lg	IDA		Rat	PMID:25972624|RGD:11344972
Cellular Component	GO:0042995	cell projection	Cd40lg	IDA		Rat	PMID:25972624|RGD:11344972
Cellular Component	GO:0009986	cell surface	CD40LG	IDA		Human	PMID:15067037
Cellular Component	GO:0009986	cell surface	Cd40lg	IDA		Rat	PMID:16425979|RGD:8547785
Cellular Component	GO:0009897	external side of plasma membrane	Cd40lg	IDA		Mouse	PMID:17082577
Cellular Component	GO:0009897	external side of plasma membrane	cd40lg	IDA		Zfish	PMID:19494299
Cellular Component	GO:0005615	extracellular space	Cd40lg	IDA		Rat	PMID:16716410|RGD:2313422
Cellular Component	GO:0005794	Golgi apparatus	CD40LG	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CD40LG	IDA		Human	GO_REF:0000052
Biological Process	GO:0030183	B cell differentiation	Cd40lg	IGI	MGI:MGI:96556	Mouse	PMID:14647274
Biological Process	GO:0042100	B cell proliferation	CD40LG	IDA		Human	PMID:8605945
Biological Process	GO:0023035	CD40 signaling pathway	CD40LG	IMP		Human	PMID:31331973
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Cd40lg	IEP		Rat	PMID:26095681|RGD:11344966
Biological Process	GO:0097028	dendritic cell differentiation	Cd40lg	IMP		Rat	PMID:18384807|RGD:2313415
Biological Process	GO:0002377	immunoglobulin production	Cd40lg	IGI	MGI:MGI:1344376	Mouse	PMID:15485634
Biological Process	GO:0006954	inflammatory response	CD40LG	IDA		Human	PMID:9468137
Biological Process	GO:0007229	integrin-mediated signaling pathway	CD40LG	IMP		Human	PMID:31331973
Biological Process	GO:0045190	isotype switching	Cd40lg	IDA		Mouse	MGI:MGI:3687427|PMID:7529792
Biological Process	GO:0043066	negative regulation of apoptotic process	CD40LG	IDA		Human	PMID:12697681
Biological Process	GO:0030168	platelet activation	CD40LG	IDA		Human	PMID:9468137
Biological Process	GO:0030890	positive regulation of B cell proliferation	Cd40lg	IDA		Rat	PMID:18384807|RGD:2313415
Biological Process	GO:2001200	positive regulation of dendritic cell differentiation	Cd40lg	IDA		Rat	PMID:18384807|RGD:2313415
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	CD40LG	IDA		Human	PMID:12885753
Biological Process	GO:0010628	positive regulation of gene expression	Cd40lg	IDA		Rat	PMID:17922253|RGD:11352689
Biological Process	GO:0002839	positive regulation of immune response to tumor cell	Cd40lg	IDA		Rat	PMID:19016771|RGD:2313413
Biological Process	GO:0002639	positive regulation of immunoglobulin production	cd40lg	IDA		Zfish	PMID:19494299
Biological Process	GO:0032733	positive regulation of interleukin-10 production	CD40LG	IDA		Human	PMID:8617933
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Cd40lg	IDA		Rat	PMID:18262271|RGD:2313421
Biological Process	GO:0032735	positive regulation of interleukin-12 production	CD40LG	IDA		Human	PMID:9922218
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Cd40lg	IDA		Rat	PMID:18384807|RGD:2313415
Biological Process	GO:0032753	positive regulation of interleukin-4 production	CD40LG	IDA		Human	PMID:8617933
Biological Process	GO:0045348	positive regulation of MHC class II biosynthetic process	Cd40lg	IDA		Rat	PMID:18262271|RGD:2313421
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	CD40LG	IDA		Human	PMID:15067037
Biological Process	GO:0042102	positive regulation of T cell proliferation	CD40LG	IDA		Human	PMID:8617933
Biological Process	GO:0032729	positive regulation of type II interferon production	Cd40lg	IDA		Rat	PMID:18262271|RGD:2313421
Biological Process	GO:0002637	regulation of immunoglobulin production	Cd40lg	IDA		Mouse	PMID:12958312
Biological Process	GO:0033590	response to cobalamin	Cd40lg	IEP		Rat	PMID:16716410|RGD:2313422
Biological Process	GO:1901652	response to peptide	Cd40lg	IEP		Rat	PMID:26840743|RGD:11344962

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern