Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD44
  • Mouse genes Cd44
  • Rat genes Cd44
  • Zfish genes cd44a,cd44b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd44

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0038024	cargo receptor activity	Cd44	IMP		Mouse	PMID:26528478
Molecular Function	GO:0038024	cargo receptor activity	Cd44	IDA		Mouse	PMID:26528478
Molecular Function	GO:0038024	cargo receptor activity	Cd44	IDA		Mouse	PMID:1703543
Molecular Function	GO:0019955	cytokine binding	Cd44	IDA		Mouse	MGI:MGI:3773489|PMID:18056708
Molecular Function	GO:0004896	cytokine receptor activity	CD44	IDA		Human	PMID:17045821
Molecular Function	GO:0004896	cytokine receptor activity	Cd44	IDA		Mouse	MGI:MGI:3690285|PMID:17045821
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Cd44	IPI	RGD:2543	Rat	PMID:21349584|RGD:5131469
Molecular Function	GO:0005540	hyaluronic acid binding	CD44	IDA		Human	PMID:17170110
Molecular Function	GO:0005540	hyaluronic acid binding	CD44	IDA		Human	PMID:17324121
Molecular Function	GO:0005540	hyaluronic acid binding	Cd44	IMP		Mouse	PMID:10926769
Molecular Function	GO:0051219	phosphoprotein binding	Cd44	IPI	RGD:3169	Rat	PMID:11316791|RGD:1599273
Molecular Function	GO:0005515	protein binding	CD44	IPI	UniProtKB:P18011	Human	PMID:11207560
Molecular Function	GO:0005515	protein binding	CD44	IPI	UniProtKB:Q86YL7	Human	PMID:20962267
Molecular Function	GO:0005515	protein binding	CD44	IPI	UniProtKB:Q9UPY5	Human	PMID:21397861
Molecular Function	GO:0005515	protein binding	CD44	IPI	UniProtKB:P26038	Human	PMID:23855374
Molecular Function	GO:0005515	protein binding	CD44	IPI	UniProtKB:P04233	Human	PMID:29190904
Molecular Function	GO:0005515	protein binding	Cd44	IPI	UniProtKB:P04441	Mouse	MGI:MGI:3773489|PMID:18056708
Molecular Function	GO:0005515	protein binding	Cd44	IPI	UniProtKB:O08573	Mouse	MGI:MGI:5688819|PMID:25065622
Molecular Function	GO:0005515	protein binding	Cd44	IPI	UniProtKB:P13609	Mouse	MGI:MGI:3715093|PMID:7535771
Molecular Function	GO:0005515	protein binding	Cd44	IPI	UniProtKB:O08573|UniProtKB:Q64729	Mouse	MGI:MGI:5688819|PMID:25065622
Molecular Function	GO:0005515	protein binding	Cd44	IPI	UniProtKB:P26040|UniProtKB:P26041|UniProtKB:P26043	Mouse	MGI:MGI:6115186|PMID:9472040
Molecular Function	GO:0005515	protein binding	Cd44	IPI	UniProtKB:Q60610|UniProtKB:Q6ZPF3	Mouse	MGI:MGI:4420511|PMID:19893486
Molecular Function	GO:0005515	protein binding	Cd44	IPI	RGD:3169	Rat	PMID:15659388|RGD:1599271
Molecular Function	GO:0019901	protein kinase binding	Cd44	IPI	RGD:2641	Rat	PMID:8103744|RGD:2324924
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	Cd44	IPI	UniProtKB:Q64729	Mouse	MGI:MGI:5688819|PMID:25065622
Cellular Component	GO:0016324	apical plasma membrane	CD44	IDA		Human	PMID:20962267
Cellular Component	GO:0016324	apical plasma membrane	Cd44	IDA		Rat	PMID:16786159|RGD:2289354
Cellular Component	GO:0016323	basolateral plasma membrane	Cd44	IDA		Mouse	PMID:10027409
Cellular Component	GO:0016323	basolateral plasma membrane	Cd44	IDA		Rat	PMID:16786159|RGD:2289354
Cellular Component	GO:0042995	cell projection	CD44	IDA		Human	PMID:20962267
Cellular Component	GO:0009986	cell surface	CD44	IDA		Human	PMID:16809613
Cellular Component	GO:0009986	cell surface	CD44	IDA		Human	PMID:17170110
Cellular Component	GO:0009986	cell surface	Cd44	IDA		Mouse	MGI:MGI:5688819|PMID:25065622
Cellular Component	GO:0009986	cell surface	Cd44	IDA		Mouse	PMID:17716972
Cellular Component	GO:0009986	cell surface	Cd44	IDA		Mouse	PMID:9324354
Cellular Component	GO:0009986	cell surface	Cd44	IDA		Rat	PMID:31723344|RGD:152176657
Cellular Component	GO:0005829	cytosol	CD44	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:19299737
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:16973387
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:7538697
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:15477346
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:18958875
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:16301745
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:10943842
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:9133426
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:22072979
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:19008373
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:19723499
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:10072077
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:21708977
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:16177108
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:14764662
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:8769481
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:7584142
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:15728238
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:21508411
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:14609575
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:10704459
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:15843532
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:15294943
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:19934022
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:17082577
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:10848813
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:20711497
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:21460847
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:16203996
Cellular Component	GO:0009897	external side of plasma membrane	Cd44	IDA		Mouse	PMID:8043862
Cellular Component	GO:0070062	extracellular exosome	CD44	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	CD44	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	CD44	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	CD44	HDA		Human	PMID:21423176
Cellular Component	GO:0005794	Golgi apparatus	CD44	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031258	lamellipodium membrane	CD44	IDA		Human	PMID:20962267
Cellular Component	GO:0035692	macrophage migration inhibitory factor receptor complex	CD44	IDA		Human	PMID:17045821
Cellular Component	GO:0035692	macrophage migration inhibitory factor receptor complex	Cd44	IDA		Mouse	MGI:MGI:3773489|PMID:18056708
Cellular Component	GO:0035692	macrophage migration inhibitory factor receptor complex	Cd44	IDA		Mouse	MGI:MGI:3690285|PMID:17045821
Cellular Component	GO:0005902	microvillus	Cd44	IDA		Mouse	MGI:MGI:6115186|PMID:9472040
Cellular Component	GO:0005634	nucleus	Cd44	IDA		Rat	PMID:16195325|RGD:2289375
Cellular Component	GO:0005886	plasma membrane	CD44	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CD44	IDA		Human	PMID:20962267
Cellular Component	GO:0005886	plasma membrane	Cd44	IDA		Mouse	PMID:9374396
Cellular Component	GO:0005886	plasma membrane	Cd44	IDA		Mouse	PMID:18085615
Cellular Component	GO:0032991	protein-containing complex	Cd44	IDA		Rat	PMID:11316791|RGD:1599273
Biological Process	GO:0001955	blood vessel maturation	Cd44	IEP		Rat	PMID:15947460|RGD:2289378
Biological Process	GO:0060442	branching involved in prostate gland morphogenesis	Cd44	IMP		Mouse	PMID:9374396
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Cd44	IMP		Mouse	PMID:10926769
Biological Process	GO:0051216	cartilage development	CD44	IEP		Human	PMID:11944887
Biological Process	GO:0007155	cell adhesion	CD44	IDA		Human	PMID:19703720
Biological Process	GO:0007155	cell adhesion	Cd44	IMP		Rat	PMID:16306150|RGD:2289374
Biological Process	GO:0016477	cell migration	CD44	IDA		Human	PMID:22726066
Biological Process	GO:0016477	cell migration	Cd44	IMP		Rat	PMID:16306150|RGD:2289374
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	CD44	IDA		Human	PMID:19577615
Biological Process	GO:0030214	hyaluronan catabolic process	CD44	IDA		Human	PMID:17170110
Biological Process	GO:0030214	hyaluronan catabolic process	Cd44	IDA		Mouse	PMID:26528478
Biological Process	GO:0030214	hyaluronan catabolic process	Cd44	IMP		Mouse	PMID:26528478
Biological Process	GO:0006954	inflammatory response	Cd44	IEP		Rat	PMID:8639178|RGD:2289388
Biological Process	GO:0034238	macrophage fusion	Cd44	IMP		Rat	PMID:16195325|RGD:2289375
Biological Process	GO:0070487	monocyte aggregation	CD44	IMP		Human	PMID:15100360
Biological Process	GO:0043066	negative regulation of apoptotic process	CD44	IMP		Human	PMID:19047049
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	Cd44	IMP		Mouse	MGI:MGI:5688819|PMID:25065622
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	CD44	IMP		Human	PMID:19047049
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	CD44	IDA		Human	PMID:17045821
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	Cd44	IMP		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:0050728	negative regulation of inflammatory response	Cd44	IMP		Mouse	MGI:MGI:5688819|PMID:25065622
Biological Process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	CD44	IDA		Human	PMID:17045821
Biological Process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Cd44	IMP		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:0002906	negative regulation of mature B cell apoptotic process	Cd44	IDA		Mouse	MGI:MGI:3773489|PMID:18056708
Biological Process	GO:0045590	negative regulation of regulatory T cell differentiation	Cd44	IMP		Mouse	MGI:MGI:5688819|PMID:25065622
Biological Process	GO:0031175	neuron projection development	Cd44	IMP		Rat	PMID:17760872|RGD:2289365
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	CD44	IDA		Human	PMID:17045821
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Cd44	IMP		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:0010628	positive regulation of gene expression	Cd44	IMP		Mouse	MGI:MGI:5688819|PMID:25065622
Biological Process	GO:0010628	positive regulation of gene expression	Cd44	IGI	MGI:MGI:99604	Mouse	PMID:9847236
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	CD44	IMP		Human	PMID:15100360
Biological Process	GO:1900625	positive regulation of monocyte aggregation	CD44	IMP		Human	PMID:20522558
Biological Process	GO:0033031	positive regulation of neutrophil apoptotic process	Cd44	IMP		Rat	PMID:11044212|RGD:2289387
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	CD44	IDA		Human	PMID:17045821
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Cd44	IMP		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	CD44	IDA		Human	PMID:17045821
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Cd44	IMP		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:0006898	receptor-mediated endocytosis	Cd44	IMP		Mouse	PMID:26528478
Biological Process	GO:0006898	receptor-mediated endocytosis	Cd44	IDA		Mouse	PMID:26528478
Biological Process	GO:0001558	regulation of cell growth	Cd44	IDA		Rat	PMID:11316791|RGD:1599273
Biological Process	GO:2000392	regulation of lamellipodium morphogenesis	CD44	IMP		Human	PMID:20962267
Biological Process	GO:0031667	response to nutrient levels	Cd44	IEP		Rat	PMID:31966914|RGD:25823185
Biological Process	GO:0014070	response to organic cyclic compound	Cd44	IEP		Rat	PMID:17105903|RGD:2289368
Biological Process	GO:0014070	response to organic cyclic compound	Cd44	IEP		Rat	PMID:31966914|RGD:25823185
Biological Process	GO:0033189	response to vitamin A	Cd44	IEP		Rat	PMID:16804311|RGD:2289372
Biological Process	GO:0042110	T cell activation	CD44	IDA		Human	PMID:7528188
Biological Process	GO:0001944	vasculature development	cd44a	IGI	ZFIN:ZDB-MRPHLNO-150615-1,ZFIN:ZDB-MRPHLNO-150825-1	Zfish	PMID:25767277
Biological Process	GO:0016055	Wnt signaling pathway	Cd44	IDA		Mouse	PMID:19056892
Biological Process	GO:0002246	wound healing involved in inflammatory response	Cd44	IMP	MGI:MGI:2181292	Mouse	PMID:11935029
Biological Process	GO:0044319	wound healing, spreading of cells	CD44	IMP		Human	PMID:20962267

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern