Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD59
  • Mouse genes Cd59a
  • Rat genes Cd59
  • Zfish genes ly97.3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd59a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001530	lipopolysaccharide binding	ly97.3	IDA		Zfish	PMID:27980020
Molecular Function	GO:0005515	protein binding	CD59	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	CD59	IPI	UniProtKB:O35587	Human	PMID:20427317
Molecular Function	GO:0005515	protein binding	CD59	IPI	UniProtKB:Q15363	Human	PMID:20427317
Molecular Function	GO:0005515	protein binding	CD59	IPI	UniProtKB:Q778I9	Human	PMID:24036449
Molecular Function	GO:0005515	protein binding	CD59	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD59	IPI	UniProtKB:P42858	Human	PMID:32814053
Cellular Component	GO:0009986	cell surface	CD59	IDA		Human	PMID:15907827
Cellular Component	GO:0009986	cell surface	Cd59a	IDA		Mouse	PMID:11471050
Cellular Component	GO:0009897	external side of plasma membrane	CD59	IDA		Human	PMID:9724629
Cellular Component	GO:0009897	external side of plasma membrane	Cd59a	IDA		Mouse	PMID:19299737
Cellular Component	GO:0009897	external side of plasma membrane	Cd59a	IDA		Mouse	PMID:18947875
Cellular Component	GO:0070062	extracellular exosome	CD59	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CD59	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	CD59	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	CD59	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	CD59	HDA		Human	PMID:16502470
Cellular Component	GO:0005925	focal adhesion	CD59	HDA		Human	PMID:21423176
Cellular Component	GO:0005886	plasma membrane	Cd59a	IDA		Mouse	PMID:11471050
Cellular Component	GO:0031982	vesicle	CD59	HDA		Human	PMID:19190083
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ly97.3	IDA		Zfish	PMID:27980020
Biological Process	GO:0001971	negative regulation of activation of membrane attack complex	Cd59a	IMP		Mouse	MGI:MGI:3828358|PMID:17237428
Biological Process	GO:0001971	negative regulation of activation of membrane attack complex	Cd59a	IDA		Mouse	PMID:11471050
Biological Process	GO:0016525	negative regulation of angiogenesis	Cd59a	IMP		Mouse	MGI:MGI:3828358|PMID:17237428
Biological Process	GO:0045916	negative regulation of complement activation	Cd59a	IDA		Mouse	MGI:MGI:3828358|PMID:17237428
Biological Process	GO:0090272	negative regulation of fibroblast growth factor production	Cd59a	IDA		Mouse	MGI:MGI:3828358|PMID:17237428
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	Cd59a	IMP		Mouse	MGI:MGI:3828358|PMID:17237428
Biological Process	GO:0030449	regulation of complement activation	CD59	IDA		Human	PMID:25284781
Biological Process	GO:1903659	regulation of complement-dependent cytotoxicity	CD59	IDA		Human	PMID:25284781
Biological Process	GO:0032496	response to lipopolysaccharide	ly97.3	IDA		Zfish	PMID:27071517

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern