Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD68
  • Mouse genes Cd68
  • Rat genes Cd68
  • Zfish genes cd68
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd68

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CD68	IPI	UniProtKB:O95994	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD68	IPI	UniProtKB:P15941-11	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD68	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD68	IPI	UniProtKB:Q7Z7N9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD68	IPI	UniProtKB:Q86UP2-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD68	IPI	UniProtKB:Q969L2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD68	IPI	UniProtKB:Q96B49	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD68	IPI	UniProtKB:Q96CS7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD68	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD68	IPI	UniProtKB:Q9UHP7-3	Human	PMID:32296183
Cellular Component	GO:0005764	lysosome	Cd68	IDA		Mouse	MGI:MGI:5285055|PMID:21572087
Cellular Component	GO:0005886	plasma membrane	CD68	IDA		Human	PMID:28601280
Cellular Component	GO:0005886	plasma membrane	Cd68	IDA		Mouse	MGI:MGI:5285055|PMID:21572087
Biological Process	GO:0007568	aging	Cd68	IEP		Mouse	MGI:MGI:6274946|PMID:16157452
Biological Process	GO:0035425	autocrine signaling	Cd68	IGI	UniProtKB:P50115|UniProtKB:P50116	Rat	PMID:27312849|RGD:13838801
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cd68	IDA		Mouse	MGI:MGI:6274946|PMID:16157452
Biological Process	GO:0031669	cellular response to nutrient levels	Cd68	IDA		Mouse	MGI:MGI:6274946|PMID:16157452
Biological Process	GO:0071310	cellular response to organic substance	Cd68	IDA		Mouse	PMID:18497889
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	Cd68	IDA		Mouse	MGI:MGI:6274946|PMID:16157452
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	Cd68	IDA		Mouse	MGI:MGI:6274946|PMID:16157452
Biological Process	GO:0002605	negative regulation of dendritic cell antigen processing and presentation	Cd68	IMP		Mouse	MGI:MGI:5285055|PMID:21572087

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern