Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD74
  • Mouse genes Cd74
  • Rat genes Cd74
  • Zfish genes cd74a,cd74b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd74

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	CD74	IPI	UniProtKB:P05067	Human	PMID:19849849
Molecular Function	GO:0042609	CD4 receptor binding	CD74	IPI	UniProtKB:P01730,UniProtKB:P01911	Human	PMID:24942581
Molecular Function	GO:0019955	cytokine binding	CD74	IPI	UniProtKB:A4GRE3	Human	PMID:17567581
Molecular Function	GO:0019955	cytokine binding	Cd74	IDA		Mouse	MGI:MGI:3773489|PMID:18056708
Molecular Function	GO:0004896	cytokine receptor activity	CD74	IDA		Human	PMID:17045821
Molecular Function	GO:0004896	cytokine receptor activity	Cd74	IMP		Mouse	MGI:MGI:4419085|PMID:12782713
Molecular Function	GO:0035718	macrophage migration inhibitory factor binding	CD74	IPI	UniProtKB:P14174	Human	PMID:17045821
Molecular Function	GO:0042289	MHC class II protein binding	Cd74	IPI	UniProtKB:P06345	Mouse	MGI:MGI:3033762|PMID:7985028
Molecular Function	GO:0042658	MHC class II protein binding, via antigen binding groove	CD74	IDA		Human	PMID:7477400
Molecular Function	GO:0023026	MHC class II protein complex binding	CD74	IDA		Human	PMID:1448172
Molecular Function	GO:0050998	nitric-oxide synthase binding	Cd74	IPI	UniProtKB:P29477	Mouse	MGI:MGI:4943392|PMID:18003616
Molecular Function	GO:0005515	protein binding	CD74	IPI	UniProtKB:P0A6Y8	Human	PMID:17357109
Molecular Function	GO:0005515	protein binding	CD74	IPI	UniProtKB:P25025	Human	PMID:17435771
Molecular Function	GO:0005515	protein binding	CD74	IPI	UniProtKB:P61073	Human	PMID:19665027
Molecular Function	GO:0005515	protein binding	CD74	IPI	UniProtKB:P16070	Human	PMID:29190904
Molecular Function	GO:0005515	protein binding	CD74	IPI	UniProtKB:P60228	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	CD74	IPI	UniProtKB:Q14974	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	Cd74	IPI	UniProtKB:P15379	Mouse	MGI:MGI:3773489|PMID:18056708
Molecular Function	GO:0005515	protein binding	Cd74	IPI	UniProtKB:P06797	Mouse	MGI:MGI:3691984|PMID:11483509
Molecular Function	GO:0005515	protein binding	Cd74	IPI	UniProtKB:P06797	Mouse	MGI:MGI:6259330|PMID:12417635
Molecular Function	GO:0005515	protein binding	Cd74	IPI	PR:P11609	Mouse	PMID:11754812
Molecular Function	GO:0005515	protein binding	Cd74	IPI	PR:P06345	Mouse	PMID:7985028
Molecular Function	GO:0044183	protein folding chaperone	CD74	IDA		Human	PMID:7477400
Cellular Component	GO:0009986	cell surface	CD74	IDA		Human	PMID:17045821
Cellular Component	GO:0009986	cell surface	CD74	IDA		Human	PMID:19665027
Cellular Component	GO:0009986	cell surface	CD74	IDA		Human	PMID:22952837
Cellular Component	GO:0009986	cell surface	cd74a	IDA		Zfish	PMID:25445909
Cellular Component	GO:0005737	cytoplasm	CD74	IDA		Human	PMID:22952837
Cellular Component	GO:0005737	cytoplasm	CD74	IDA		Human	PMID:24569872
Cellular Component	GO:0005783	endoplasmic reticulum	Cd74	IDA		Mouse	PMID:11854359
Cellular Component	GO:0009897	external side of plasma membrane	Cd74	IDA		Mouse	PMID:7679955
Cellular Component	GO:0009897	external side of plasma membrane	Cd74	IDA		Mouse	PMID:19723499
Cellular Component	GO:0009897	external side of plasma membrane	Cd74	IDA		Mouse	PMID:15322158
Cellular Component	GO:0070062	extracellular exosome	CD74	HDA		Human	PMID:20458337
Cellular Component	GO:0005615	extracellular space	Cd74	IDA		Mouse	MGI:MGI:6259330|PMID:12417635
Cellular Component	GO:0005794	Golgi apparatus	Cd74	IDA		Mouse	PMID:11854359
Cellular Component	GO:0005770	late endosome	Cd74	IDA		Mouse	MGI:MGI:3691984|PMID:11483509
Cellular Component	GO:0005770	late endosome	Cd74	IDA		Mouse	PMID:15294975
Cellular Component	GO:0005764	lysosome	Cd74	IDA		Mouse	MGI:MGI:3691984|PMID:11483509
Cellular Component	GO:0005764	lysosome	Cd74	IDA		Mouse	PMID:11854359
Cellular Component	GO:0005764	lysosome	Cd74	IDA		Mouse	PMID:15294975
Cellular Component	GO:0035692	macrophage migration inhibitory factor receptor complex	CD74	IDA		Human	PMID:17045821
Cellular Component	GO:0035692	macrophage migration inhibitory factor receptor complex	Cd74	IDA		Mouse	MGI:MGI:3773489|PMID:18056708
Cellular Component	GO:0035692	macrophage migration inhibitory factor receptor complex	Cd74	IDA		Mouse	MGI:MGI:4419085|PMID:12782713
Cellular Component	GO:0016020	membrane	CD74	IDA		Human	PMID:12782713
Cellular Component	GO:0016020	membrane	CD74	HDA		Human	PMID:19946888
Cellular Component	GO:0042613	MHC class II protein complex	Cd74	IDA		Mouse	MGI:MGI:3033762|PMID:7985028
Cellular Component	GO:0005771	multivesicular body	Cd74	IDA		Mouse	PMID:11854359
Cellular Component	GO:0035693	NOS2-CD74 complex	Cd74	IDA		Mouse	MGI:MGI:4943392|PMID:18003616
Cellular Component	GO:0005634	nucleus	CD74	IDA		Human	PMID:19423618
Cellular Component	GO:0005886	plasma membrane	CD74	IDA		Human	PMID:19665027
Cellular Component	GO:0005886	plasma membrane	CD74	IDA		Human	PMID:22952837
Cellular Component	GO:0005886	plasma membrane	CD74	IDA		Human	PMID:24569872
Cellular Component	GO:0005886	plasma membrane	Cd74	IDA		Mouse	PMID:11854359
Cellular Component	GO:0005886	plasma membrane	Cd74	IDA		Mouse	PMID:8294875
Cellular Component	GO:0005886	plasma membrane	Cd74	IMP	MGI:MGI:1927530	Mouse	PMID:8098731
Cellular Component	GO:0005886	plasma membrane	Cd74	IMP	MGI:MGI:1927544	Mouse	PMID:8294875
Cellular Component	GO:0032991	protein-containing complex	CD74	IDA		Human	PMID:19665027
Cellular Component	GO:0005773	vacuole	CD74	IDA		Human	PMID:19849849
Biological Process	GO:0019882	antigen processing and presentation	Cd74	IDA		Mouse	PMID:3864916
Biological Process	GO:0019882	antigen processing and presentation	Cd74	IDA		Mouse	PMID:7985028
Biological Process	GO:0019882	antigen processing and presentation	Cd74	IMP	MGI:MGI:1927530	Mouse	PMID:9432982
Biological Process	GO:0019882	antigen processing and presentation	Cd74	IDA		Mouse	PMID:11754812
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Cd74	IMP	MGI:MGI:1927205	Mouse	PMID:8598040
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Cd74	IMP	MGI:MGI:1927205	Mouse	PMID:7679955
Biological Process	GO:0008283	cell population proliferation	Cd74	IDA		Rat	PMID:12782713|RGD:728220
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	Cd74	IMP	MGI:MGI:1927205	Mouse	PMID:7679955
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding	Cd74	IDA		Mouse	PMID:7985028
Biological Process	GO:0006952	defense response	Cd74	IMP	MGI:MGI:1927530	Mouse	PMID:8098731
Biological Process	GO:0006952	defense response	Cd74	IMP	MGI:MGI:1927544	Mouse	PMID:8294875
Biological Process	GO:0002468	dendritic cell antigen processing and presentation	cd74a	IDA		Zfish	PMID:25445909
Biological Process	GO:0016064	immunoglobulin mediated immune response	Cd74	IMP	MGI:MGI:1927205	Mouse	PMID:7679955
Biological Process	GO:0048839	inner ear development	cd74a	IGI	ZFIN:ZDB-MRPHLNO-120323-6,ZFIN:ZDB-MRPHLNO-120323-8	Zfish	PMID:22210003
Biological Process	GO:0048839	inner ear development	cd74b	IGI	ZFIN:ZDB-MRPHLNO-120323-6,ZFIN:ZDB-MRPHLNO-120323-8	Zfish	PMID:22210003
Biological Process	GO:0006886	intracellular protein transport	Cd74	IMP	MGI:MGI:1927205	Mouse	PMID:7679955
Biological Process	GO:0006886	intracellular protein transport	Cd74	IDA		Mouse	PMID:15294975
Biological Process	GO:0006886	intracellular protein transport	Cd74	IDA		Mouse	PMID:11754812
Biological Process	GO:0035691	macrophage migration inhibitory factor signaling pathway	Cd74	IDA		Mouse	MGI:MGI:4943655|PMID:19413900
Biological Process	GO:0043066	negative regulation of apoptotic process	CD74	IDA		Human	PMID:12782713
Biological Process	GO:0030336	negative regulation of cell migration	CD74	IMP		Human	PMID:20198449
Biological Process	GO:0030336	negative regulation of cell migration	CD74	IMP		Human	PMID:22952837
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	CD74	IDA		Human	PMID:17045821
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	Cd74	IMP		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	CD74	IMP		Human	PMID:17045821
Biological Process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Cd74	IMP		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:0002906	negative regulation of mature B cell apoptotic process	Cd74	IMP		Mouse	MGI:MGI:3773489|PMID:18056708
Biological Process	GO:0002792	negative regulation of peptide secretion	CD74	IDA		Human	PMID:19849849
Biological Process	GO:0045581	negative regulation of T cell differentiation	Cd74	IMP	MGI:MGI:1927205	Mouse	PMID:7679955
Biological Process	GO:0045060	negative thymic T cell selection	Cd74	IMP	MGI:MGI:1927205	Mouse	PMID:7679955
Biological Process	GO:0048884	neuromast development	cd74a	IGI	ZFIN:ZDB-MRPHLNO-120323-6,ZFIN:ZDB-MRPHLNO-120323-8	Zfish	PMID:22210003
Biological Process	GO:0048884	neuromast development	cd74b	IGI	ZFIN:ZDB-MRPHLNO-120323-6,ZFIN:ZDB-MRPHLNO-120323-8	Zfish	PMID:22210003
Biological Process	GO:0030890	positive regulation of B cell proliferation	CD74	IMP		Human	PMID:12782713
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	Cd74	IDA		Mouse	MGI:MGI:4943655|PMID:19413900
Biological Process	GO:0032722	positive regulation of chemokine production	CD74	IMP		Human	PMID:19423618
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	CD74	IMP		Human	PMID:12782713
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	Cd74	IMP		Mouse	MGI:MGI:4419085|PMID:12782713
Biological Process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	Cd74	IDA		Mouse	MGI:MGI:4943392|PMID:18003616
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CD74	IDA		Human	PMID:24942581
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	CD74	IMP		Human	PMID:12782713
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	CD74	IDA		Human	PMID:17045821
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	CD74	IDA		Human	PMID:24942581
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Cd74	IMP		Mouse	MGI:MGI:4419085|PMID:12782713
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	CD74	IMP		Human	PMID:12782713
Biological Process	GO:0010628	positive regulation of gene expression	CD74	IMP		Human	PMID:19423618
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	CD74	IDA		Human	PMID:24942581
Biological Process	GO:0032755	positive regulation of interleukin-6 production	CD74	IMP		Human	PMID:24569872
Biological Process	GO:0032757	positive regulation of interleukin-8 production	CD74	IMP		Human	PMID:24569872
Biological Process	GO:0033674	positive regulation of kinase activity	CD74	IDA		Human	PMID:24942581
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Cd74	IDA		Mouse	MGI:MGI:4943655|PMID:19413900
Biological Process	GO:2000448	positive regulation of macrophage migration inhibitory factor signaling pathway	CD74	IMP		Human	PMID:19665027
Biological Process	GO:0043410	positive regulation of MAPK cascade	CD74	IDA		Human	PMID:24942581
Biological Process	GO:0043410	positive regulation of MAPK cascade	Cd74	IDA		Rat	PMID:12782713|RGD:728220
Biological Process	GO:0045657	positive regulation of monocyte differentiation	CD74	IDA		Human	PMID:24942581
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	Cd74	IDA		Mouse	MGI:MGI:4943655|PMID:19413900
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	CD74	IDA		Human	PMID:17045821
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Cd74	IMP		Mouse	MGI:MGI:3690285|PMID:17045821
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	CD74	IMP		Human	PMID:24569872
Biological Process	GO:0001934	positive regulation of protein phosphorylation	CD74	IDA		Human	PMID:24942581
Biological Process	GO:0045582	positive regulation of T cell differentiation	Cd74	IMP	MGI:MGI:1927205	Mouse	PMID:8598040
Biological Process	GO:0045582	positive regulation of T cell differentiation	Cd74	IMP	MGI:MGI:1927530	Mouse	PMID:9432982
Biological Process	GO:0045582	positive regulation of T cell differentiation	Cd74	IMP	MGI:MGI:1927205	Mouse	PMID:7679955
Biological Process	GO:0002830	positive regulation of type 2 immune response	Cd74	IMP		Mouse	MGI:MGI:2158514|PMID:11823488
Biological Process	GO:0046598	positive regulation of viral entry into host cell	CD74	IDA		Human	PMID:24942581
Biological Process	GO:0045059	positive thymic T cell selection	Cd74	IMP	MGI:MGI:1927205	Mouse	PMID:8598040
Biological Process	GO:0045059	positive thymic T cell selection	Cd74	IMP	MGI:MGI:1927205	Mouse	PMID:7679955
Biological Process	GO:0045059	positive thymic T cell selection	Cd74	IMP	MGI:MGI:1927530	Mouse	PMID:9432982
Biological Process	GO:0001516	prostaglandin biosynthetic process	CD74	IDA		Human	PMID:12782713
Biological Process	GO:0050821	protein stabilization	Cd74	IMP		Mouse	MGI:MGI:6259330|PMID:12417635
Biological Process	GO:0050821	protein stabilization	Cd74	IMP		Mouse	MGI:MGI:3691984|PMID:11483509
Biological Process	GO:0065003	protein-containing complex assembly	Cd74	IDA		Mouse	PMID:7985028
Biological Process	GO:0034341	response to type II interferon	CD74	IDA		Human	PMID:32855215
Biological Process	GO:0034341	response to type II interferon	Cd74	IDA		Mouse	MGI:MGI:6478071|PMID:32855215
Biological Process	GO:0002286	T cell activation involved in immune response	cd74a	IDA		Zfish	PMID:25445909

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern