Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD81
  • Mouse genes Cd81
  • Rat genes Cd81
  • Zfish genes cd81a,cd81b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd81

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015485	cholesterol binding	CD81	IDA		Human	PMID:27881302
Molecular Function	GO:0005178	integrin binding	CD81	IDA		Human	PMID:12796480
Molecular Function	GO:0005178	integrin binding	CD81	IDA		Human	PMID:27993971
Molecular Function	GO:0042289	MHC class II protein binding	CD81	IDA		Human	PMID:8409388
Molecular Function	GO:0023026	MHC class II protein complex binding	CD81	HDA		Human	PMID:20458337
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P27958:PRO_0000037570	Human	PMID:10400713
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q969P0	Human	PMID:11504738
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P27958:PRO_0000037570	Human	PMID:12522210
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P27958:PRO_0000037570	Human	PMID:12604806
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P05107	Human	PMID:12796480
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P21926	Human	PMID:12796480
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P42356	Human	PMID:14676841
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q99IB8:PRO_0000045596	Human	PMID:19088272
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:O14672	Human	PMID:19587294
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:O14672:PRO_0000029067	Human	PMID:19587294
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:O95484|UniProtKB:O95832|UniProtKB:P56747	Human	PMID:20375010
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P11049	Human	PMID:21930792
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P19397	Human	PMID:21930792
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q6UWF3	Human	PMID:21930792
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:O14672	Human	PMID:23091066
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P05362	Human	PMID:23858057
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P20963	Human	PMID:23858057
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P21926	Human	PMID:23858057
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P13164	Human	PMID:2398277
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P13164	Human	PMID:26354436
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:O14672	Human	PMID:26686862
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P27958:PRO_0000037570	Human	PMID:26808496
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q99IB8:PRO_0000045596	Human	PMID:26808496
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q9Y3Z3	Human	PMID:28871089
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q8WTV0	Human	PMID:30024968
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:O14524-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P35212	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q10589	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q13113	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q14739	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q16623	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q5T7V8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q5VUM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q7Z7G2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q8TAF8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q8TED1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q8WY91	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q96PE7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q9BXS9-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q9NR31	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q9NSU2-1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q9Y320	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q9Y676	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:O14672	Human	PMID:32900848
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:Q8WTV0	Human	PMID:32900848
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P13164	Human	PMID:8409388
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P01730	Human	PMID:9168119
Molecular Function	GO:0005515	protein binding	CD81	IPI	UniProtKB:P27958:PRO_0000037570	Human	PMID:9794763
Molecular Function	GO:0005515	protein binding	Cd81	IPI	UniProtKB:P40240|UniProtKB:Q8R366|UniProtKB:Q9WV91	Mouse	MGI:MGI:6282938|PMID:23575678
Molecular Function	GO:0005515	protein binding	Cd81	IPI	UniProtKB:P09055,UniProtKB:P11835,UniProtKB:P20491,UniProtKB:Q08857	Mouse	MGI:MGI:5700288|PMID:23395392
Molecular Function	GO:0005515	protein binding	Cd81	IPI	PR:Q8R366	Mouse	PMID:11504738
Molecular Function	GO:0005515	protein binding	Cd81	IPI	PR:Q8R366	Mouse	PMID:11673522
Molecular Function	GO:0005515	protein binding	Cd81	IPI	UniProtKB:Q62786	Rat	PMID:11278880|RGD:8553711
Molecular Function	GO:0005515	protein binding	Cd81	IPI	RGD:628869	Rat	PMID:17684062|RGD:2302243
Molecular Function	GO:1990459	transferrin receptor binding	CD81	IPI	UniProtKB:Q9UP52	Human	PMID:25635054
Molecular Function	GO:0001618	virus receptor activity	CD81	IMP		Human	PMID:20375010
Cellular Component	GO:0016324	apical plasma membrane	Cd81	IDA		Rat	PMID:17684062|RGD:2302243
Cellular Component	GO:0009925	basal plasma membrane	CD81	IDA		Human	PMID:31791063
Cellular Component	GO:0016323	basolateral plasma membrane	CD81	IDA		Human	PMID:20375010
Cellular Component	GO:0070062	extracellular exosome	CD81	IDA		Human	PMID:15908444
Cellular Component	GO:0070062	extracellular exosome	CD81	IDA		Human	PMID:19028452
Cellular Component	GO:0070062	extracellular exosome	CD81	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CD81	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	CD81	IDA		Human	PMID:21235781
Cellular Component	GO:0070062	extracellular exosome	CD81	IDA		Human	PMID:21276792
Cellular Component	GO:0070062	extracellular exosome	CD81	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	CD81	IDA		Human	PMID:30871575
Cellular Component	GO:0005925	focal adhesion	CD81	HDA		Human	PMID:21423176
Cellular Component	GO:0001772	immunological synapse	CD81	IDA		Human	PMID:21930792
Cellular Component	GO:0001772	immunological synapse	CD81	IDA		Human	PMID:23858057
Cellular Component	GO:0016020	membrane	CD81	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	CD81	IDA		Human	PMID:27881302
Cellular Component	GO:0016020	membrane	Cd81	IDA		Mouse	MGI:MGI:5700288|PMID:23395392
Cellular Component	GO:0016020	membrane	Cd81	IDA		Rat	PMID:8757260|RGD:631951
Cellular Component	GO:0005886	plasma membrane	CD81	IDA		Human	PMID:14676841
Cellular Component	GO:0005886	plasma membrane	CD81	IDA		Human	PMID:20237408
Cellular Component	GO:0005886	plasma membrane	CD81	IDA		Human	PMID:22307619
Cellular Component	GO:0005886	plasma membrane	CD81	IDA		Human	PMID:26354436
Cellular Component	GO:0005886	plasma membrane	CD81	IDA		Human	PMID:8409388
Cellular Component	GO:0097197	tetraspanin-enriched microdomain	CD81	IDA		Human	PMID:28871089
Cellular Component	GO:0031982	vesicle	CD81	IDA		Human	PMID:9360996
Biological Process	GO:0035783	CD4-positive, alpha-beta T cell costimulation	CD81	IDA		Human	PMID:22307619
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	Cd81	IDA		Mouse	MGI:MGI:5700288|PMID:23395392
Biological Process	GO:0002455	humoral immune response mediated by circulating immunoglobulin	CD81	IMP		Human	PMID:20237408
Biological Process	GO:0001771	immunological synapse formation	CD81	IMP		Human	PMID:23858057
Biological Process	GO:0034238	macrophage fusion	CD81	IDA		Human	PMID:12796480
Biological Process	GO:0034238	macrophage fusion	Cd81	IMP		Mouse	MGI:MGI:2663571|PMID:12796480
Biological Process	GO:0014905	myoblast fusion involved in skeletal muscle regeneration	Cd81	IMP		Mouse	MGI:MGI:6282938|PMID:23575678
Biological Process	GO:0072675	osteoclast fusion	Cd81	IMP		Mouse	MGI:MGI:2663571|PMID:12796480
Biological Process	GO:0043128	positive regulation of 1-phosphatidylinositol 4-kinase activity	CD81	IDA		Human	PMID:14676841
Biological Process	GO:1905676	positive regulation of adaptive immune memory response	CD81	IMP		Human	PMID:20237408
Biological Process	GO:0050871	positive regulation of B cell activation	Cd81	IMP		Mouse	MGI:MGI:5476553|PMID:23499492
Biological Process	GO:0030890	positive regulation of B cell proliferation	CD81	IDA		Human	PMID:10400713
Biological Process	GO:0050861	positive regulation of B cell receptor signaling pathway	CD81	IMP		Human	PMID:20237408
Biological Process	GO:0050861	positive regulation of B cell receptor signaling pathway	Cd81	IMP		Mouse	MGI:MGI:5476553|PMID:23499492
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	CD81	IDA		Human	PMID:22307619
Biological Process	GO:0008284	positive regulation of cell population proliferation	CD81	IDA		Human	PMID:14676841
Biological Process	GO:0002863	positive regulation of inflammatory response to antigenic stimulus	Cd81	IMP		Mouse	MGI:MGI:1926561|PMID:11046035
Biological Process	GO:0043410	positive regulation of MAPK cascade	CD81	IDA		Human	PMID:14676841
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	CD81	IDA		Human	PMID:14676841
Biological Process	GO:1904352	positive regulation of protein catabolic process in the vacuole	CD81	IMP		Human	PMID:25635054
Biological Process	GO:0070863	positive regulation of protein exit from endoplasmic reticulum	CD81	IMP		Human	PMID:16449649
Biological Process	GO:1903911	positive regulation of receptor clustering	CD81	IDA		Human	PMID:23858057
Biological Process	GO:1903911	positive regulation of receptor clustering	Cd81	IMP		Mouse	MGI:MGI:5476553|PMID:23499492
Biological Process	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	CD81	IDA		Human	PMID:8766544
Biological Process	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	Cd81	IMP		Mouse	MGI:MGI:1926561|PMID:11046035
Biological Process	GO:0050862	positive regulation of T cell receptor signaling pathway	CD81	IMP		Human	PMID:23858057
Biological Process	GO:2000553	positive regulation of T-helper 2 cell cytokine production	CD81	IDA		Human	PMID:8766544
Biological Process	GO:2000553	positive regulation of T-helper 2 cell cytokine production	Cd81	IMP		Mouse	MGI:MGI:1926561|PMID:11046035
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	CD81	IGI	UniProtKB:Q9UP52	Human	PMID:25635054
Biological Process	GO:0008104	protein localization	CD81	IDA		Human	PMID:14676841
Biological Process	GO:0061462	protein localization to lysosome	CD81	IMP		Human	PMID:25635054
Biological Process	GO:0072659	protein localization to plasma membrane	CD81	IMP		Human	PMID:20237408
Biological Process	GO:0072659	protein localization to plasma membrane	CD81	IDA		Human	PMID:27881302
Biological Process	GO:0031623	receptor internalization	Cd81	IDA		Mouse	MGI:MGI:5700288|PMID:23395392
Biological Process	GO:2000145	regulation of cell motility	Cd81	IGI	MGI:MGI:2154090	Mouse	PMID:11673522
Biological Process	GO:0042127	regulation of cell population proliferation	Cd81	IDA		Rat	PMID:11773042|RGD:724646
Biological Process	GO:0040008	regulation of growth	Cd81	IEP		Rat	PMID:8757260|RGD:631951
Biological Process	GO:1905521	regulation of macrophage migration	Cd81	IDA		Mouse	MGI:MGI:3820146|PMID:18662991
Biological Process	GO:0031647	regulation of protein stability	CD81	IMP		Human	PMID:25635054
Biological Process	GO:0009611	response to wounding	Cd81	IEP		Rat	PMID:8757260|RGD:631951

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern