Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD86
  • Mouse genes Cd86
  • Rat genes Cd86
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd86

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CD86	IPI	UniProtKB:P16410	Human	PMID:11279501
Molecular Function	GO:0005515	protein binding	CD86	IPI	UniProtKB:P16410	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	CD86	IPI	UniProtKB:P16410	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CD86	IPI	UniProtKB:P10747	Human	PMID:9915850
Molecular Function	GO:0005515	protein binding	Cd86	IPI	UniProtKB:O35129,UniProtKB:P67778	Mouse	MGI:MGI:5461234|PMID:23241883
Molecular Function	GO:0048018	receptor ligand activity	CD86	IDA		Human	PMID:24845157
Molecular Function	GO:0005102	signaling receptor binding	Cd86	IPI	RGD:735932	Rat	PMID:17289805|RGD:4892273
Molecular Function	GO:0005102	signaling receptor binding	Cd86	IPI	RGD:737465	Rat	PMID:17289805|RGD:4892273
Cellular Component	GO:0009986	cell surface	CD86	HDA		Human	PMID:23981064
Cellular Component	GO:0009986	cell surface	Cd86	IDA		Rat	PMID:15474526|RGD:151665813
Cellular Component	GO:0009986	cell surface	Cd86	IDA		Rat	PMID:9237108|RGD:632472
Cellular Component	GO:0034451	centriolar satellite	CD86	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009897	external side of plasma membrane	Cd86	IDA		Mouse	PMID:14643301
Cellular Component	GO:0009897	external side of plasma membrane	Cd86	IDA		Mouse	PMID:15240714
Cellular Component	GO:0009897	external side of plasma membrane	Cd86	IDA		Mouse	PMID:15314074
Cellular Component	GO:0009897	external side of plasma membrane	Cd86	IDA		Mouse	PMID:17277142
Cellular Component	GO:0009897	external side of plasma membrane	Cd86	IDA		Mouse	PMID:14560001
Cellular Component	GO:0009897	external side of plasma membrane	Cd86	IDA		Mouse	PMID:12801066
Cellular Component	GO:0070062	extracellular exosome	CD86	IDA		Human	PMID:15908444
Cellular Component	GO:0070062	extracellular exosome	CD86	HDA		Human	PMID:20458337
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Cd86	IDA		Mouse	PMID:16708399
Cellular Component	GO:0005886	plasma membrane	CD86	IDA		Human	GO_REF:0000052
Biological Process	GO:0007202	activation of phospholipase C activity	Cd86	IDA		Mouse	MGI:MGI:5461234|PMID:23241883
Biological Process	GO:1990051	activation of protein kinase C activity	Cd86	IDA		Mouse	MGI:MGI:5461234|PMID:23241883
Biological Process	GO:0007568	aging	Cd86	IEP		Rat	PMID:15890435|RGD:2313439
Biological Process	GO:0042113	B cell activation	Cd86	IDA		Mouse	MGI:MGI:5461234|PMID:23241883
Biological Process	GO:0042113	B cell activation	Cd86	IDA		Mouse	PMID:19734906
Biological Process	GO:0023035	CD40 signaling pathway	Cd86	IDA		Mouse	MGI:MGI:5461234|PMID:23241883
Biological Process	GO:0071345	cellular response to cytokine stimulus	Cd86	IEP		Rat	PMID:19642897|RGD:4892214
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cd86	IDA		Mouse	PMID:19047410
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cd86	IEP		Rat	PMID:21039614|RGD:4892198
Biological Process	GO:0071248	cellular response to metal ion	Cd86	IEP		Rat	PMID:19653805|RGD:4892213
Biological Process	GO:0051607	defense response to virus	Cd86	IDA		Mouse	PMID:17277142
Biological Process	GO:0051607	defense response to virus	Cd86	IEP		Rat	PMID:20603637|RGD:4892200
Biological Process	GO:0043011	myeloid dendritic cell differentiation	Cd86	IEP		Rat	PMID:21039614|RGD:4892198
Biological Process	GO:0002668	negative regulation of T cell anergy	Cd86	IMP		Rat	PMID:18424705|RGD:4892228
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Cd86	IDA		Rat	PMID:9237108|RGD:632472
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Cd86	IDA		Mouse	MGI:MGI:5461234|PMID:23241883
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Cd86	IDA		Mouse	MGI:MGI:5461234|PMID:23241883
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd86	IGI	MGI:MGI:101775	Mouse	PMID:23793062
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd86	IMP		Rat	PMID:19107191|RGD:4892215
Biological Process	GO:0032496	response to lipopolysaccharide	Cd86	IEP		Rat	PMID:17935670|RGD:2313436
Biological Process	GO:0034341	response to type II interferon	Cd86	IEP		Rat	PMID:16839612|RGD:2313438
Biological Process	GO:0009410	response to xenobiotic stimulus	Cd86	IEP		Rat	PMID:18704298|RGD:4892225
Biological Process	GO:0001878	response to yeast	Cd86	IEP		Rat	PMID:19494083|RGD:2313435
Biological Process	GO:0042110	T cell activation	CD86	IDA		Human	PMID:7527824
Biological Process	GO:0002309	T cell proliferation involved in immune response	Cd86	IEP		Rat	PMID:20500684|RGD:4892204
Biological Process	GO:0034138	toll-like receptor 3 signaling pathway	Cd86	IMP		Mouse	MGI:MGI:5645190|PMID:25158758
Biological Process	GO:0002224	toll-like receptor signaling pathway	Cd86	IDA		Mouse	PMID:19734906

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern