Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD8A
  • Mouse genes Cd8a
  • Rat genes Cd8a
  • Zfish genes cd8a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd8a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	Cd8a	IPI	PR:P01731	Mouse	PMID:15749886
Molecular Function	GO:0023024	MHC class I protein complex binding	CD8A	IDA		Human	PMID:2784196
Molecular Function	GO:0023024	MHC class I protein complex binding	CD8A	IDA		Human	PMID:9177355
Molecular Function	GO:0005515	protein binding	CD8A	IPI	UniProtKB:P17693	Human	PMID:12853576
Molecular Function	GO:0005515	protein binding	CD8A	IPI	UniProtKB:P06239	Human	PMID:2470098
Molecular Function	GO:0005515	protein binding	CD8A	IPI	UniProtKB:P10966	Human	PMID:2493728
Molecular Function	GO:0005515	protein binding	CD8A	IPI	UniProtKB:P04439	Human	PMID:9177355
Molecular Function	GO:0005515	protein binding	Cd8a	IPI	UniProtKB:P06240	Mouse	MGI:MGI:3690806|PMID:7664803
Molecular Function	GO:0005515	protein binding	Cd8a	IPI	UniProtKB:P06240	Mouse	MGI:MGI:5532887|PMID:24034254
Molecular Function	GO:0005515	protein binding	Cd8a	IPI	UniProtKB:Q3U531	Mouse	PMID:15749886
Molecular Function	GO:0019901	protein kinase binding	Cd8a	IPI	RGD:2641	Rat	PMID:1372996|RGD:2324896
Cellular Component	GO:0009986	cell surface	Cd8a	IDA		Mouse	PMID:14568922
Cellular Component	GO:0009986	cell surface	Cd8a	IDA		Rat	PMID:11734593|RGD:150527855
Cellular Component	GO:0009986	cell surface	Cd8a	IDA		Rat	PMID:15474526|RGD:151665813
Cellular Component	GO:0009986	cell surface	Cd8a	IDA		Rat	PMID:17436231|RGD:150527854
Cellular Component	GO:0009986	cell surface	Cd8a	IDA		Rat	PMID:18292522|RGD:6482823
Cellular Component	GO:0009986	cell surface	Cd8a	IDA		Rat	PMID:19022963|RGD:150527853
Cellular Component	GO:0009897	external side of plasma membrane	CD8A	IDA		Human	PMID:17213291
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:19934022
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:17082577
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:18776904
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:10072077
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:22072979
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:10943842
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:15843532
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:15322158
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:17357106
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:18836449
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:21508411
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:10704459
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:19349303
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:9208839
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:16455951
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:6610701
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:15728238
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:15240714
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:16287714
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:10648399
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:19723499
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:8788039
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:7589135
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:17277142
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:1673361
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:15294943
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:18984740
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:16973387
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:20709950
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:14609575
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:19838199
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:21460847
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:8688082
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:15795238
Cellular Component	GO:0009897	external side of plasma membrane	Cd8a	IDA		Mouse	PMID:8755570
Cellular Component	GO:0005886	plasma membrane	CD8A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CD8A	IDA		Human	PMID:2784196
Cellular Component	GO:0044853	plasma membrane raft	CD8A	IDA		Human	PMID:17341584
Cellular Component	GO:0043235	receptor complex	CD8A	IPI		Human	PMID:17243170
Cellular Component	GO:0043235	receptor complex	Cd8a	IPI		Mouse	MGI:MGI:6810793|PMID:22081144
Biological Process	GO:0019722	calcium-mediated signaling	Cd8a	IDA		Mouse	PMID:9208839
Biological Process	GO:0007166	cell surface receptor signaling pathway	Cd8a	IDA		Mouse	PMID:9208839
Biological Process	GO:0045065	cytotoxic T cell differentiation	Cd8a	IMP	MGI:MGI:1857149	Mouse	PMID:1673361
Biological Process	GO:0051607	defense response to virus	Cd8a	IDA		Mouse	PMID:17277142
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	Cd8a	IDA		Mouse	PMID:9208839
Biological Process	GO:0042110	T cell activation	CD8A	IDA		Human	PMID:17145893
Biological Process	GO:0042110	T cell activation	Cd8a	IMP		Rat	PMID:10458478|RGD:1625382
Biological Process	GO:0002456	T cell mediated immunity	Cd8a	IMP	MGI:MGI:1857149	Mouse	PMID:1673361
Biological Process	GO:0050852	T cell receptor signaling pathway	CD8A	IDA		Human	PMID:17145893

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern