Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CDC6
  • Mouse genes Cdc6
  • Rat genes Cdc6
  • Zfish genes cdc6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdc6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Cdc6	IDA		Mouse	PMID:14667810
Molecular Function	GO:0019900	kinase binding	CDC6	IPI	UniProtKB:P06493	Human	PMID:21041660
Molecular Function	GO:0005515	protein binding	CDC6	IPI	UniProtKB:Q9H211	Human	PMID:14672932
Molecular Function	GO:0005515	protein binding	CDC6	IPI	UniProtKB:P38936	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDC6	IPI	UniProtKB:Q9H211	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDC6	IPI	UniProtKB:O95801	Human	PMID:18320024
Molecular Function	GO:0005515	protein binding	CDC6	IPI	UniProtKB:O75179	Human	PMID:19150984
Molecular Function	GO:0005515	protein binding	CDC6	IPI	UniProtKB:P06493	Human	PMID:21041660
Molecular Function	GO:0005515	protein binding	CDC6	IPI	UniProtKB:P53350	Human	PMID:21041660
Molecular Function	GO:0005515	protein binding	CDC6	IPI	UniProtKB:P38936	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CDC6	IPI	UniProtKB:P41002	Human	PMID:25557911
Molecular Function	GO:0005515	protein binding	CDC6	IPI	UniProtKB:Q9BQ67	Human	PMID:25990725
Molecular Function	GO:0005515	protein binding	Cdc6	IPI	UniProtKB:Q6PEC4	Rat	PMID:18356301|RGD:13432308
Cellular Component	GO:0005737	cytoplasm	Cdc6	IDA		Mouse	PMID:14667810
Cellular Component	GO:0005829	cytosol	CDC6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045171	intercellular bridge	CDC6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0072686	mitotic spindle	CDC6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CDC6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CDC6	IDA		Human	PMID:21041660
Cellular Component	GO:0005634	nucleus	CDC6	IDA		Human	PMID:21383955
Cellular Component	GO:0005819	spindle	Cdc6	IDA		Mouse	PMID:14667810
Cellular Component	GO:0051233	spindle midzone	CDC6	IDA		Human	PMID:21041660
Cellular Component	GO:0000922	spindle pole	CDC6	IDA		Human	PMID:21041660
Biological Process	GO:1904385	cellular response to angiotensin	Cdc6	IEP		Rat	PMID:12063292|RGD:625751
Biological Process	GO:1904117	cellular response to vasopressin	Cdc6	IEP		Rat	PMID:12063292|RGD:625751
Biological Process	GO:0000278	mitotic cell cycle	CDC6	IMP		Human	PMID:22581055
Biological Process	GO:0044772	mitotic cell cycle phase transition	cdc6	IMP	ZFIN:ZDB-GENO-180705-2	Zfish	PMID:28985365
Biological Process	GO:0051984	positive regulation of chromosome segregation	CDC6	IDA		Human	PMID:21041660
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	Cdc6	IMP		Rat	PMID:22223646|RGD:10045360
Biological Process	GO:0032467	positive regulation of cytokinesis	CDC6	IMP		Human	PMID:21041660
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Cdc6	IDA		Rat	PMID:22223646|RGD:10045360
Biological Process	GO:0030071	regulation of mitotic metaphase/anaphase transition	CDC6	IMP		Human	PMID:21041660

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern