Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CDH5
  • Mouse genes Cdh5
  • Rat genes Cdh5
  • Zfish genes cdh5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdh5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	CDH5	IPI	UniProtKB:P35222	Human	PMID:18287330
Molecular Function	GO:0070700	BMP receptor binding	CDH5	IPI	UniProtKB:Q04771	Human	PMID:26598555
Molecular Function	GO:0070700	BMP receptor binding	CDH5	IPI	UniProtKB:Q13873	Human	PMID:26598555
Molecular Function	GO:0070051	fibrinogen binding	CDH5	IMP		Human	PMID:19413351
Molecular Function	GO:0005515	protein binding	CDH5	IPI	UniProtKB:Q06124	Human	PMID:15985432
Molecular Function	GO:0005515	protein binding	CDH5	IPI	UniProtKB:P35222	Human	PMID:17057644
Molecular Function	GO:0005515	protein binding	CDH5	IPI	UniProtKB:Q8TEW0	Human	PMID:17057644
Molecular Function	GO:0005515	protein binding	CDH5	IPI	UniProtKB:Q9NPB6	Human	PMID:17057644
Molecular Function	GO:0005515	protein binding	CDH5	IPI	UniProtKB:P35222	Human	PMID:18287330
Molecular Function	GO:0005515	protein binding	CDH5	IPI	UniProtKB:P35222	Human	PMID:18662404
Molecular Function	GO:0005515	protein binding	CDH5	IPI	UniProtKB:P23381	Human	PMID:20010843
Molecular Function	GO:0005515	protein binding	CDH5	IPI	UniProtKB:P35222	Human	PMID:20123964
Molecular Function	GO:0005515	protein binding	CDH5	IPI	UniProtKB:O00522	Human	PMID:20332120
Molecular Function	GO:0005515	protein binding	CDH5	IPI	UniProtKB:Q9NQC3-2	Human	PMID:21183689
Molecular Function	GO:0005515	protein binding	CDH5	IPI	UniProtKB:P18206	Human	PMID:26923917
Molecular Function	GO:0005515	protein binding	CDH5	IPI	UniProtKB:P35222	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Cdh5	IPI	UniProtKB:B2RU80	Mouse	MGI:MGI:4419091|PMID:12234928
Molecular Function	GO:0005515	protein binding	Cdh5	IPI	UniProtKB:Q62312|UniProtKB:Q64729	Mouse	MGI:MGI:5508595|PMID:18337748
Molecular Function	GO:0005515	protein binding	Cdh5	IPI	PR:P41241	Mouse	PMID:15861137
Molecular Function	GO:0005515	protein binding	Cdh5	IPI	PR:Q99M80	Mouse	PMID:16973135
Molecular Function	GO:0019903	protein phosphatase binding	CDH5	IPI	UniProtKB:P23467	Human	PMID:28926625
Molecular Function	GO:0019903	protein phosphatase binding	CDH5	IPI	UniProtKB:Q12913	Human	PMID:28926625
Molecular Function	GO:0019903	protein phosphatase binding	CDH5	IPI	UniProtKB:Q16827	Human	PMID:28926625
Molecular Function	GO:0019903	protein phosphatase binding	CDH5	IPI	UniProtKB:Q9HD43	Human	PMID:28926625
Molecular Function	GO:0019903	protein phosphatase binding	Cdh5	IPI	UniProtKB:O14522	Mouse	MGI:MGI:3689290|PMID:16973135
Molecular Function	GO:1990782	protein tyrosine kinase binding	CDH5	IPI	UniProtKB:P35968	Human	PMID:11950700
Molecular Function	GO:0005102	signaling receptor binding	CDH5	IPI	UniProtKB:Q99571	Human	PMID:12088286
Molecular Function	GO:0044325	transmembrane transporter binding	CDH5	IPI	UniProtKB:Q9UBN4	Human	PMID:19996314
Molecular Function	GO:0043184	vascular endothelial growth factor receptor 2 binding	CDH5	IPI	UniProtKB:P35968	Human	PMID:25893857
Cellular Component	GO:0005912	adherens junction	CDH5	IDA		Human	PMID:25978380
Cellular Component	GO:0005912	adherens junction	CDH5	IDA		Human	PMID:26598555
Cellular Component	GO:0005912	adherens junction	CDH5	IMP		Human	PMID:26923917
Cellular Component	GO:0005912	adherens junction	Cdh5	IDA		Mouse	MGI:MGI:5796260|PMID:25978380
Cellular Component	GO:0005912	adherens junction	Cdh5	IDA		Mouse	PMID:19129494
Cellular Component	GO:0005923	bicellular tight junction	Cdh5	IDA		Mouse	PMID:10508865
Cellular Component	GO:0030054	cell junction	Cdh5	IDA		Mouse	MGI:MGI:4359570|PMID:19635461
Cellular Component	GO:0071944	cell periphery	Cdh5	IDA		Mouse	PMID:16455951
Cellular Component	GO:0009986	cell surface	CDH5	IDA		Human	PMID:23288152
Cellular Component	GO:0005911	cell-cell junction	CDH5	IDA		Human	PMID:15572031
Cellular Component	GO:0005911	cell-cell junction	CDH5	IDA		Human	PMID:19996314
Cellular Component	GO:0005911	cell-cell junction	CDH5	IDA		Human	PMID:20332120
Cellular Component	GO:0005911	cell-cell junction	CDH5	IDA		Human	PMID:21168935
Cellular Component	GO:0005911	cell-cell junction	CDH5	IDA		Human	PMID:23288152
Cellular Component	GO:0005911	cell-cell junction	Cdh5	IDA		Mouse	PMID:15861137
Cellular Component	GO:0005911	cell-cell junction	Cdh5	IDA		Mouse	PMID:21884682
Cellular Component	GO:0009897	external side of plasma membrane	Cdh5	IDA		Mouse	PMID:20711984
Cellular Component	GO:0031965	nuclear membrane	CDH5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CDH5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CDH5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CDH5	IDA		Human	PMID:25978380
Cellular Component	GO:0005886	plasma membrane	Cdh5	IDA		Mouse	MGI:MGI:5796260|PMID:25978380
Biological Process	GO:0034332	adherens junction organization	CDH5	IDA		Human	PMID:26598555
Biological Process	GO:0120077	angiogenic sprout fusion	cdh5	IMP		Zfish	PMID:28264837
Biological Process	GO:0070830	bicellular tight junction assembly	CDH5	IMP		Human	PMID:25753039
Biological Process	GO:1902354	blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment	cdh5	IMP	ZFIN:ZDB-GENO-130809-4	Zfish	PMID:23698350
Biological Process	GO:0043534	blood vessel endothelial cell migration	CDH5	IMP		Human	PMID:31934175
Biological Process	GO:0072554	blood vessel lumenization	cdh5	IMP	ZFIN:ZDB-MRPHLNO-100908-10	Zfish	PMID:23000899
Biological Process	GO:0072554	blood vessel lumenization	cdh5	IMP	ZFIN:ZDB-MRPHLNO-100908-10	Zfish	PMID:20736288
Biological Process	GO:0072554	blood vessel lumenization	cdh5	IMP	ZFIN:ZDB-TALEN-131118-4	Zfish	PMID:23000899
Biological Process	GO:0001955	blood vessel maturation	Cdh5	IMP	MGI:MGI:1857669	Mouse	PMID:15855637
Biological Process	GO:0120078	cell adhesion involved in sprouting angiogenesis	cdh5	IGI	ZFIN:ZDB-GENO-170620-9	Zfish	PMID:28264837
Biological Process	GO:0098609	cell-cell adhesion	CDH5	IDA		Human	PMID:15572031
Biological Process	GO:0098609	cell-cell adhesion	Cdh5	IMP		Mouse	PMID:21884682
Biological Process	GO:0044331	cell-cell adhesion mediated by cadherin	CDH5	IDA		Human	PMID:26598555
Biological Process	GO:0007043	cell-cell junction assembly	CDH5	IMP		Human	PMID:23288152
Biological Process	GO:0045216	cell-cell junction organization	cdh5	IMP	ZFIN:ZDB-GENO-200521-7	Zfish	PMID:30171187
Biological Process	GO:0061300	cerebellum vasculature development	cdh5	IMP	ZFIN:ZDB-MRPHLNO-080506-1	Zfish	PMID:28429770
Biological Process	GO:1902355	endothelial tube lumen extension involved in blood vessel lumen ensheathment	cdh5	IMP	ZFIN:ZDB-GENO-130809-4	Zfish	PMID:23698350
Biological Process	GO:0007507	heart development	cdh5	IMP	ZFIN:ZDB-MRPHLNO-070810-2	Zfish	PMID:20098718
Biological Process	GO:0007507	heart development	cdh5	IMP	ZFIN:ZDB-MRPHLNO-100520-10	Zfish	PMID:20098718
Biological Process	GO:0006874	intracellular calcium ion homeostasis	CDH5	IDA		Human	PMID:23159740
Biological Process	GO:0016525	negative regulation of angiogenesis	cdh5	IMP	ZFIN:ZDB-MRPHLNO-080506-1	Zfish	PMID:19345098
Biological Process	GO:0016525	negative regulation of angiogenesis	cdh5	IMP	ZFIN:ZDB-MRPHLNO-100430-2	Zfish	PMID:19345098
Biological Process	GO:0008285	negative regulation of cell population proliferation	Cdh5	IGI	MGI:MGI:88537	Mouse	PMID:15861137
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	CDH5	IMP		Human	PMID:31934175
Biological Process	GO:0050728	negative regulation of inflammatory response	CDH5	IGI	RNAcentral:URS0000096022_9606	Human	PMID:28112401
Biological Process	GO:0031115	negative regulation of microtubule polymerization	CDH5	IDA		Human	PMID:23159740
Biological Process	GO:0045766	positive regulation of angiogenesis	CDH5	IGI	RNAcentral:URS0000209905_9606	Human	PMID:22391569
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	CDH5	IMP		Human	PMID:26598555
Biological Process	GO:0030335	positive regulation of cell migration	CDH5	IDA		Human	PMID:15572031
Biological Process	GO:1903142	positive regulation of establishment of endothelial barrier	CDH5	IMP		Human	PMID:23288152
Biological Process	GO:0010628	positive regulation of gene expression	CDH5	IMP		Human	PMID:26598555
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	CDH5	IMP		Human	PMID:11950700
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	CDH5	IMP		Human	PMID:26598555
Biological Process	GO:1902396	protein localization to bicellular tight junction	CDH5	IMP	UniProtKB:P18206|UniProtKB:P33151|UniProtKB:Q13177|UniProtKB:Q9UKX2	Human	PMID:25753039
Biological Process	GO:2000114	regulation of establishment of cell polarity	CDH5	IMP		Human	PMID:20332120
Biological Process	GO:2000114	regulation of establishment of cell polarity	Cdh5	IMP		Mouse	MGI:MGI:4943837|PMID:20332120
Biological Process	GO:0001932	regulation of protein phosphorylation	CDH5	IDA		Human	PMID:23159740
Biological Process	GO:0043114	regulation of vascular permeability	CDH5	IDA		Human	PMID:26598555
Biological Process	GO:1901342	regulation of vasculature development	cdh5	IGI	ZFIN:ZDB-GENO-180920-25,ZFIN:ZDB-MRPHLNO-070810-2	Zfish	PMID:29744287
Biological Process	GO:0002040	sprouting angiogenesis	cdh5	IMP	ZFIN:ZDB-MRPHLNO-100430-2	Zfish	PMID:19345098
Biological Process	GO:0002040	sprouting angiogenesis	cdh5	IMP	ZFIN:ZDB-MRPHLNO-080506-1	Zfish	PMID:19345098
Biological Process	GO:0002040	sprouting angiogenesis	cdh5	IMP	ZFIN:ZDB-GENO-130923-7	Zfish	PMID:25373898
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	CDH5	IDA		Human	PMID:21168935
Biological Process	GO:0009826	unidimensional cell growth	cdh5	IMP	ZFIN:ZDB-GENO-130923-7	Zfish	PMID:25373898
Biological Process	GO:0001944	vasculature development	cdh5	IGI	ZFIN:ZDB-MIRNAG-050103-9	Zfish	PMID:28112401

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern