Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CDK1
  • Mouse genes Cdk1
  • Rat genes Cdk1
  • Zfish genes cdk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0010698	acetyltransferase activator activity	CDK1	IDA		Human	PMID:26829474
Molecular Function	GO:0001671	ATPase activator activity	CDK1	IDA		Human	PMID:28575661
Molecular Function	GO:0003682	chromatin binding	Cdk1	IDA		Mouse	PMID:18625720
Molecular Function	GO:0030332	cyclin binding	CDK1	IPI	UniProtKB:P20248	Human	PMID:1312467
Molecular Function	GO:0030332	cyclin binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:24746669
Molecular Function	GO:0030332	cyclin binding	CDK1	IDA		Human	PMID:7739547
Molecular Function	GO:0030332	cyclin binding	Cdk1	IPI	RGD:2294	Rat	PMID:15696186|RGD:2301349
Molecular Function	GO:0097472	cyclin-dependent protein kinase activity	CDK1	IDA		Human	PMID:1312467
Molecular Function	GO:0097472	cyclin-dependent protein kinase activity	Cdk1	IDA		Mouse	PMID:27565725
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	CDK1	IDA		Human	PMID:10791892
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	CDK1	IDA		Human	PMID:11069302
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	CDK1	IDA		Human	PMID:18477460
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	CDK1	IDA		Human	PMID:23601106
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	CDK1	IMP		Human	PMID:24746669
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	CDK1	IDA		Human	PMID:25753036
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Cdk1	IDA		Mouse	MGI:MGI:5318128|PMID:22405274
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Cdk1	IDA		Rat	PMID:9753325|RGD:632911
Molecular Function	GO:0008047	enzyme activator activity	CDK1	IDA		Human	PMID:28575661
Molecular Function	GO:0035173	histone kinase activity	CDK1	IDA		Human	PMID:21871177
Molecular Function	GO:0035173	histone kinase activity	Cdk1	IDA		Rat	PMID:19821535|RGD:2316313
Molecular Function	GO:0030544	Hsp70 protein binding	Cdk1	IPI	PR:P17156	Mouse	PMID:9247342
Molecular Function	GO:0016301	kinase activity	CDK1	IDA		Human	PMID:28575661
Molecular Function	GO:0016301	kinase activity	Cdk1	IDA		Mouse	PMID:12124778
Molecular Function	GO:0016301	kinase activity	Cdk1	IDA		Mouse	PMID:12937170
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q99640	Human	PMID:10373560
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:O15392-1	Human	PMID:11069302
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P31947	Human	PMID:11574543
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q07812	Human	PMID:11574543
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q9H4X1	Human	PMID:11687586
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:12612082
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q9UKT4	Human	PMID:15148369
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P00533	Human	PMID:15657067
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:O75618-1	Human	PMID:17283331
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:17283331
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P30307	Human	PMID:17349584
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:O15392	Human	PMID:17681274
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:18337751
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:18408765
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q12778	Human	PMID:18408765
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:O14974	Human	PMID:18477460
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:19879842
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P0CG48	Human	PMID:20395957
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P19525	Human	PMID:20395957
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q99741	Human	PMID:21041660
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P23396	Human	PMID:21871177
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q8IVT2	Human	PMID:23509069
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:23543736
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P38936	Human	PMID:23543736
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P46527	Human	PMID:23543736
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q9Y3Z3	Human	PMID:23601106
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P38936	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P46527	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P61024	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q99640	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:23799914
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P38936	Human	PMID:24218572
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:24358021
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P46527	Human	PMID:24358021
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:O95835	Human	PMID:25218637
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P61024	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P61024	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q99640	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P38936	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P61024	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q99IB8:PRO_0000045596	Human	PMID:26808496
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q3UV55	Human	PMID:27238018
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:27626412
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P30307	Human	PMID:27880917
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P38936	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P46527	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P61024	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q99640	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P21796	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P36957	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q86V81	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P38936	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P38936	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P46527	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P61024	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:Q99640	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:O43508	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P27986-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:33037310
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P46527	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P03070	Human	PMID:7815540
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:P14635	Human	PMID:9001210
Molecular Function	GO:0005515	protein binding	CDK1	IPI	UniProtKB:O95835	Human	PMID:9988268
Molecular Function	GO:0005515	protein binding	Cdk1	IPI	UniProtKB:Q8IWB6	Mouse	MGI:MGI:5318128|PMID:22405274
Molecular Function	GO:0005515	protein binding	Cdk1	IPI	UniProtKB:P51943|UniProtKB:Q61457	Mouse	MGI:MGI:4412428|PMID:19592082
Molecular Function	GO:0005515	protein binding	Cdk1	IPI	UniProtKB:Q61457	Mouse	MGI:MGI:3722223|PMID:17700700
Molecular Function	GO:0005515	protein binding	Cdk1	IPI	UniProtKB:P20263	Mouse	MGI:MGI:5462499|PMID:23108051
Molecular Function	GO:0005515	protein binding	Cdk1	IPI	PR:Q9DBX1	Mouse	PMID:11687586
Molecular Function	GO:0005515	protein binding	Cdk1	IPI	PR:P48316	Mouse	PMID:12124778
Molecular Function	GO:0005515	protein binding	Cdk1	IPI	PR:P39689	Mouse	PMID:12124778
Molecular Function	GO:0005515	protein binding	Cdk1	IPI	UniProtKB:Q62839	Rat	PMID:9753325|RGD:632911
Molecular Function	GO:0005515	protein binding	Cdk1	IPI	UniProtKB:Q9Z2P4	Rat	PMID:9756947|RGD:633887
Molecular Function	GO:0004672	protein kinase activity	CDK1	IDA		Human	PMID:22854038
Molecular Function	GO:0004672	protein kinase activity	CDK1	IDA		Human	PMID:23574715
Molecular Function	GO:0004674	protein serine/threonine kinase activity	CDK1	IDA		Human	PMID:11298763
Molecular Function	GO:0004674	protein serine/threonine kinase activity	CDK1	IDA		Human	PMID:19879842
Molecular Function	GO:0004674	protein serine/threonine kinase activity	CDK1	IDA		Human	PMID:21871177
Molecular Function	GO:0004674	protein serine/threonine kinase activity	CDK1	IDA		Human	PMID:23509069
Molecular Function	GO:0004674	protein serine/threonine kinase activity	CDK1	IDA		Human	PMID:26829474
Molecular Function	GO:0004674	protein serine/threonine kinase activity	CDK1	IDA		Human	PMID:27030108
Molecular Function	GO:0004674	protein serine/threonine kinase activity	CDK1	IDA		Human	PMID:7588608
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Cdk1	IDA		Mouse	MGI:MGI:6280798|PMID:29518391
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	CDK1	IDA		Human	PMID:12721286
Cellular Component	GO:0005813	centrosome	CDK1	IDA		Human	PMID:17488717
Cellular Component	GO:0000781	chromosome, telomeric region	CDK1	HDA		Human	PMID:19135898
Cellular Component	GO:0097125	cyclin B1-CDK1 complex	CDK1	IPI		Human	PMID:17495531
Cellular Component	GO:0097125	cyclin B1-CDK1 complex	CDK1	IMP		Human	PMID:24746669
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	CDK1	IDA		Human	PMID:1312467
Cellular Component	GO:0005737	cytoplasm	CDK1	IDA		Human	PMID:15767402
Cellular Component	GO:0005737	cytoplasm	Cdk1	IDA		Rat	PMID:19298605|RGD:2314685
Cellular Component	GO:0005829	cytosol	CDK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	CDK1	HDA		Human	PMID:19056867
Cellular Component	GO:0016020	membrane	CDK1	HDA		Human	PMID:19946888
Cellular Component	GO:0030496	midbody	CDK1	IDA		Human	PMID:11069302
Cellular Component	GO:0005759	mitochondrial matrix	CDK1	IDA		Human	PMID:24746669
Cellular Component	GO:0005759	mitochondrial matrix	Cdk1	IDA		Mouse	MGI:MGI:5883204|PMID:24746669
Cellular Component	GO:0072686	mitotic spindle	CDK1	IDA		Human	PMID:17488717
Cellular Component	GO:0005654	nucleoplasm	CDK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CDK1	IDA		Human	PMID:16109376
Cellular Component	GO:0005634	nucleus	CDK1	IDA		Human	PMID:15767402
Cellular Component	GO:0005634	nucleus	Cdk1	IDA		Rat	PMID:15696186|RGD:2301349
Cellular Component	GO:0005876	spindle microtubule	CDK1	IDA		Human	PMID:11069302
Biological Process	GO:0031100	animal organ regeneration	Cdk1	IMP		Rat	PMID:15696186|RGD:2301349
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Cdk1	IEP		Rat	PMID:16179908|RGD:2316486
Biological Process	GO:0071407	cellular response to organic cyclic compound	Cdk1	IDA		Rat	PMID:15695611|RGD:2301352
Biological Process	GO:0030261	chromosome condensation	Cdk1	IMP		Rat	PMID:15695611|RGD:2301352
Biological Process	GO:0030855	epithelial cell differentiation	CDK1	IEP		Human	PMID:21492153
Biological Process	GO:0048144	fibroblast proliferation	Cdk1	IDA		Mouse	PMID:18625720
Biological Process	GO:0090166	Golgi disassembly	Cdk1	IDA		Rat	PMID:9753325|RGD:632911
Biological Process	GO:1902850	microtubule cytoskeleton organization involved in mitosis	CDK1	IDA		Human	PMID:10791892
Biological Process	GO:0000278	mitotic cell cycle	Cdk1	IEP		Rat	PMID:19821535|RGD:2316313
Biological Process	GO:0044772	mitotic cell cycle phase transition	Cdk1	IMP		Mouse	PMID:18625720
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	Cdk1	IDA		Mouse	PMID:12937170
Biological Process	GO:0043066	negative regulation of apoptotic process	CDK1	IDA		Human	PMID:11069302
Biological Process	GO:0010629	negative regulation of gene expression	Cdk1	IMP		Rat	PMID:28350193|RGD:40902962
Biological Process	GO:0018105	peptidyl-serine phosphorylation	CDK1	IDA		Human	PMID:11298763
Biological Process	GO:0018105	peptidyl-serine phosphorylation	CDK1	IDA		Human	PMID:19879842
Biological Process	GO:0018105	peptidyl-serine phosphorylation	CDK1	IDA		Human	PMID:25753036
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Cdk1	IDA		Rat	PMID:9753325|RGD:632911
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	CDK1	IDA		Human	PMID:11298763
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	CDK1	IDA		Human	PMID:25753036
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	CDK1	IMP		Human	PMID:27238018
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	Cdk1	IMP		Rat	PMID:15253691|RGD:2301353
Biological Process	GO:0045740	positive regulation of DNA replication	Cdk1	IMP		Rat	PMID:19821535|RGD:2316313
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	CDK1	IMP		Human	PMID:24746669
Biological Process	GO:0010628	positive regulation of gene expression	Cdk1	IMP		Rat	PMID:28350193|RGD:40902962
Biological Process	GO:0010628	positive regulation of gene expression	Cdk1	IMP		Rat	PMID:18356527|RGD:2316481
Biological Process	GO:1905448	positive regulation of mitochondrial ATP synthesis coupled electron transport	CDK1	IMP		Human	PMID:24746669
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	Cdk1	IMP		Rat	PMID:15696186|RGD:2301349
Biological Process	GO:0062033	positive regulation of mitotic sister chromatid segregation	CDK1	IDA		Human	PMID:26829474
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Cdk1	IMP		Rat	PMID:18356527|RGD:2316481
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	CDK1	IMP		Human	PMID:21871177
Biological Process	GO:0034501	protein localization to kinetochore	CDK1	IDA		Human	PMID:18195732
Biological Process	GO:0006468	protein phosphorylation	CDK1	IDA		Human	PMID:23509069
Biological Process	GO:0006468	protein phosphorylation	CDK1	IDA		Human	PMID:23574715
Biological Process	GO:0006468	protein phosphorylation	CDK1	IMP		Human	PMID:24746669
Biological Process	GO:0006468	protein phosphorylation	CDK1	IDA		Human	PMID:30723163
Biological Process	GO:0006468	protein phosphorylation	Cdk1	IDA		Mouse	PMID:19139267
Biological Process	GO:0006468	protein phosphorylation	Cdk1	IDA		Mouse	PMID:12124778
Biological Process	GO:0065003	protein-containing complex assembly	Cdk1	IDA		Rat	PMID:19136513|RGD:2316317
Biological Process	GO:0042752	regulation of circadian rhythm	CDK1	IMP		Human	PMID:27238018
Biological Process	GO:0009794	regulation of mitotic cell cycle, embryonic	cdk1	IMP		Zfish	PMID:19063878
Biological Process	GO:0014823	response to activity	Cdk1	IEP		Rat	PMID:16826023|RGD:2301346
Biological Process	GO:0014075	response to amine	Cdk1	IEP		Rat	PMID:16155410|RGD:2316487
Biological Process	GO:0048678	response to axon injury	Cdk1	IEP		Rat	PMID:17200138|RGD:2316482
Biological Process	GO:0046686	response to cadmium ion	Cdk1	IEP		Rat	PMID:16730872|RGD:2293566
Biological Process	GO:0046688	response to copper ion	Cdk1	IEP		Rat	PMID:19497425|RGD:2316369
Biological Process	GO:0045471	response to ethanol	Cdk1	IDA		Rat	PMID:18181150|RGD:2301342
Biological Process	GO:0042542	response to hydrogen peroxide	Cdk1	IEP		Rat	PMID:16963227|RGD:2301344
Biological Process	GO:0014070	response to organic cyclic compound	Cdk1	IEP		Rat	PMID:16427046|RGD:2301347
Biological Process	GO:0010243	response to organonitrogen compound	Cdk1	IDA		Rat	PMID:15696186|RGD:2301349
Biological Process	GO:0009636	response to toxic substance	Cdk1	IEP		Rat	PMID:19237604|RGD:2316478
Biological Process	GO:0009410	response to xenobiotic stimulus	Cdk1	IEP		Rat	PMID:16427046|RGD:2301347
Biological Process	GO:0055015	ventricular cardiac muscle cell development	Cdk1	IEP		Rat	PMID:15253691|RGD:2301353

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern