Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CDK12
  • Mouse genes Cdk12
  • Rat genes Cdk12
  • Zfish genes cdk12
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdk12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030332	cyclin binding	CDK12	IPI	UniProtKB:O75909	Human	PMID:22012619
Molecular Function	GO:0030332	cyclin binding	Cdk12	IDA		Rat	PMID:16537916|RGD:8553775
Molecular Function	GO:0030332	cyclin binding	Cdk12	IPI	UniProtKB:Q5I0H5	Rat	PMID:16537916|RGD:8553775
Molecular Function	GO:0030332	cyclin binding	Cdk12	IPI	UniProtKB:Q9R1Q2	Rat	PMID:16537916|RGD:8553775
Molecular Function	GO:0005515	protein binding	CDK12	IPI	UniProtKB:Q9JMG6	Human	PMID:12841360
Molecular Function	GO:0004672	protein kinase activity	CDK12	IDA		Human	PMID:11683387
Molecular Function	GO:0019901	protein kinase binding	Cdk12	IDA		Mouse	PMID:22547058
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	CDK12	IMP		Human	PMID:20952539
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	CDK12	IDA		Human	PMID:22988298
Cellular Component	GO:0002944	cyclin K-CDK12 complex	CDK12	IPI		Human	PMID:26597175
Cellular Component	GO:0002944	cyclin K-CDK12 complex	CDK12	IPI	UniProtKB:O75909	Human	PMID:22012619
Cellular Component	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	Cdk12	IDA		Rat	PMID:16537916|RGD:8553775
Cellular Component	GO:0016607	nuclear speck	CDK12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	CDK12	IDA		Human	PMID:11683387
Cellular Component	GO:0016607	nuclear speck	Cdk12	IDA		Rat	PMID:16537916|RGD:8553775
Cellular Component	GO:0005654	nucleoplasm	CDK12	IDA		Human	GO_REF:0000052
Biological Process	GO:2000737	negative regulation of stem cell differentiation	Cdk12	IMP		Mouse	PMID:22547058
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	CDK12	IMP		Human	PMID:20952539
Biological Process	GO:0046777	protein autophosphorylation	CDK12	IDA		Human	PMID:11683387
Biological Process	GO:0043405	regulation of MAP kinase activity	CDK12	IMP		Human	PMID:19651820
Biological Process	GO:0043484	regulation of RNA splicing	Cdk12	IDA		Rat	PMID:16537916|RGD:8553775
Biological Process	GO:0008380	RNA splicing	Cdk12	IMP		Rat	PMID:16537916|RGD:8553775
Biological Process	GO:0006366	transcription by RNA polymerase II	CDK12	IDA		Human	PMID:22988298

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern