Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cdk4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CDK4
- Mouse genes Cdk4
- Rat genes Cdk4
- Zfish genes cdk4
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdk4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030332	cyclin binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:19124461
Molecular Function	GO:0030332	cyclin binding	Cdk4	IPI	PR:P30282	Mouse	PMID:23109711
Molecular Function	GO:0030332	cyclin binding	Cdk4	IPI	RGD:2293	Rat	PMID:15809057\|RGD:1582338
Molecular Function	GO:0030332	cyclin binding	Cdk4	IPI	RGD:621083	Rat	PMID:15809057\|RGD:1582338
Molecular Function	GO:0030332	cyclin binding	Cdk4	IPI	RGD:68384	Rat	PMID:15809057\|RGD:1582338
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	CDK4	IDA		Human	PMID:19237565
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	CDK4	IDA		Human	PMID:8114739
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Cdk4	IDA		Mouse	PMID:12970171
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Cdk4	IDA		Mouse	PMID:12970760
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Cdk4	IDA		Rat	PMID:12163013\|RGD:704385
Molecular Function	GO:0016301	kinase activity	Cdk4	IDA		Mouse	PMID:12124778
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30279	Human	PMID:11896535
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:11896535
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:O75832	Human	PMID:11900540
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:14641107
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P49715	Human	PMID:15107404
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P38936	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q8N720	Human	PMID:15558030
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:15681588
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P55273	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P46527	Human	PMID:16326706
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P50613	Human	PMID:16327805
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:16431923
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P38936	Human	PMID:16962592
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P46527	Human	PMID:17053782
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771	Human	PMID:17517622
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771	Human	PMID:17909018
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771	Human	PMID:17955473
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:19237555
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:19237565
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:19447967
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:19470470
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P46527	Human	PMID:19470470
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:20399237
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:21242975
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q16543	Human	PMID:21871133
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:21900206
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P01106	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42773	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P01106	Human	PMID:22094256
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P28749	Human	PMID:22094256
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P08238	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42773	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P09936	Human	PMID:23543736
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:23543736
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P38936	Human	PMID:23543736
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P46527	Human	PMID:23543736
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42773	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P46527	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P55273	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q16543	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:24218572
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:24855949
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771	Human	PMID:24855949
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42773	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P55273	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q16543	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q16543	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P46527	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42773	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P55273	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q9UJC3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:25502805
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30279	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42773	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P55273	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q9UJC3	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30279	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42773	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P55273	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q16543	Human	PMID:27339980
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q8TF40	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q9P278	Human	PMID:27353360
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P08238	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30279	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P38936	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42773	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P46527	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P55273	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q16543	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P38936	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:31217276
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q9UH17	Human	PMID:31217276
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30279	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42773	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P55273	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q9UJC3	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30279	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42773	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P55273	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q0VD86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q8N720	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q9UJC3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q9UKT9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q9ULD0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42773	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P46527	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P55273	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q16543	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P46527	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:7568034
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42772	Human	PMID:8078588
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771	Human	PMID:8259215
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P55273	Human	PMID:8741839
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:8756624
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P38936	Human	PMID:8756624
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P24385	Human	PMID:9106657
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P30281	Human	PMID:9106657
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P38936	Human	PMID:9106657
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P46527	Human	PMID:9106657
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:Q16543	Human	PMID:9150368
Molecular Function	GO:0005515	protein binding	CDK4	IPI	UniProtKB:P42771-1	Human	PMID:9529249
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P25322	Mouse	MGI:MGI:3613336\|PMID:16413468
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P24385	Mouse	MGI:MGI:5512954\|PMID:19409388
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P25322	Mouse	MGI:MGI:5512954\|PMID:19409388
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P25322	Mouse	MGI:MGI:3613334\|PMID:16413469
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P25322	Mouse	MGI:MGI:4837754\|PMID:20951943
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P06400	Mouse	MGI:MGI:3700399\|PMID:17045206
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P25322	Mouse	MGI:MGI:3760191\|PMID:17940036
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P46414	Mouse	MGI:MGI:3613336\|PMID:16413468
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P06400	Mouse	MGI:MGI:3703656\|PMID:17349581
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P25322	Mouse	MGI:MGI:3763977\|PMID:17948060
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P25322	Mouse	MGI:MGI:3654865\|PMID:16864783
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P53566	Mouse	MGI:MGI:5619486\|PMID:15107404
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P25322	Mouse	MGI:MGI:4820703\|PMID:19767775
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P25322	Mouse	MGI:MGI:5315333\|PMID:21242975
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P25322	Mouse	MGI:MGI:4439220\|PMID:20150892
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	UniProtKB:P46414	Mouse	MGI:MGI:3839493\|PMID:19276117
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	PR:Q61026	Mouse	PMID:12130539
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	PR:P63017	Mouse	PMID:12588994
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	PR:P30282	Mouse	PMID:26657864
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	PR:Q9Z1L3	Mouse	PMID:21135503
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	PR:P46414	Mouse	PMID:8033213
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	PR:P39689	Mouse	PMID:12124778
Molecular Function	GO:0005515	protein binding	Cdk4	IPI	PR:P39689	Mouse	PMID:12970760
Molecular Function	GO:0004672	protein kinase activity	Cdk4	IDA		Mouse	PMID:12588994
Molecular Function	GO:0004672	protein kinase activity	Cdk4	IDA		Mouse	PMID:12130539
Molecular Function	GO:0004672	protein kinase activity	Cdk4	IDA		Mouse	PMID:21508411
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Cdk4	IMP		Mouse	PMID:26657864
Molecular Function	GO:0044877	protein-containing complex binding	Cdk4	IPI	RGD:68384\|RGD:69328	Rat	PMID:8651753\|RGD:2289148
Cellular Component	GO:0005923	bicellular tight junction	Cdk4	IDA		Mouse	PMID:21411630
Cellular Component	GO:0000785	chromatin	CDK4	IDA		Human	PMID:18827403
Cellular Component	GO:0097128	cyclin D1-CDK4 complex	CDK4	IPI		Human	PMID:19237565
Cellular Component	GO:0097128	cyclin D1-CDK4 complex	Cdk4	IPI		Mouse	MGI:MGI:3763977\|PMID:17948060
Cellular Component	GO:0097129	cyclin D2-CDK4 complex	CDK4	IPI		Human	PMID:11896535
Cellular Component	GO:0097129	cyclin D2-CDK4 complex	Cdk4	IDA		Mouse	PMID:8543804
Cellular Component	GO:0097129	cyclin D2-CDK4 complex	Cdk4	IDA		Mouse	PMID:7739547
Cellular Component	GO:0097130	cyclin D3-CDK4 complex	CDK4	IPI		Human	PMID:19237555
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	CDK4	IDA		Human	PMID:17420273
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	CDK4	IDA		Human	PMID:18827403
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	Cdk4	IPI	PR:P39689	Mouse	PMID:12970760
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	Cdk4	IPI	PR:P25322	Mouse	PMID:12970760
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	Cdk4	IPI	PR:P17918	Mouse	PMID:12970760
Cellular Component	GO:0005737	cytoplasm	Cdk4	IDA		Mouse	PMID:26657864
Cellular Component	GO:0005829	cytosol	CDK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	CDK4	IDA		Human	PMID:18827403
Cellular Component	GO:0031965	nuclear membrane	CDK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031965	nuclear membrane	CDK4	IDA		Human	PMID:18827403
Cellular Component	GO:0005730	nucleolus	CDK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	CDK4	IDA		Human	PMID:18827403
Cellular Component	GO:0005654	nucleoplasm	CDK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CDK4	IDA		Human	PMID:16109376
Cellular Component	GO:0005634	nucleus	CDK4	IDA		Human	PMID:18827403
Cellular Component	GO:0005634	nucleus	CDK4	IDA		Human	PMID:20399237
Cellular Component	GO:0005634	nucleus	Cdk4	IDA		Mouse	PMID:26657864
Cellular Component	GO:0005634	nucleus	Cdk4	IDA		Mouse	PMID:15645444
Cellular Component	GO:0005634	nucleus	Cdk4	IDA		Mouse	PMID:12917627
Cellular Component	GO:0005634	nucleus	Cdk4	IDA		Mouse	PMID:8988060
Cellular Component	GO:0005634	nucleus	Cdk4	IDA		Mouse	PMID:10082561
Cellular Component	GO:0005634	nucleus	Cdk4	IDA		Mouse	PMID:21411630
Cellular Component	GO:0005634	nucleus	Cdk4	IDA		Rat	PMID:7585545\|RGD:2293587
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Cdk4	IDA		Rat	PMID:15161838\|RGD:2293571
Cellular Component	GO:0032991	protein-containing complex	Cdk4	IDA		Mouse	PMID:26657864
Cellular Component	GO:0005667	transcription regulator complex	Cdk4	IDA		Mouse	PMID:10082561
Biological Process	GO:0060612	adipose tissue development	Cdk4	IMP	MGI:MGI:2154521	Mouse	PMID:26657864
Biological Process	GO:0060612	adipose tissue development	Cdk4	IMP	MGI:MGI:2154520	Mouse	PMID:26657864
Biological Process	GO:0031100	animal organ regeneration	Cdk4	IEP		Rat	PMID:16534847\|RGD:2289284
Biological Process	GO:0032869	cellular response to insulin stimulus	Cdk4	IMP	MGI:MGI:2154521	Mouse	PMID:26657864
Biological Process	GO:0071353	cellular response to interleukin-4	Cdk4	IDA		Mouse	PMID:8543804
Biological Process	GO:1904637	cellular response to ionomycin	Cdk4	IDA		Mouse	PMID:8543804
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cdk4	IDA		Mouse	PMID:8543804
Biological Process	GO:1904628	cellular response to phorbol 13-acetate 12-myristate	Cdk4	IDA		Mouse	PMID:8543804
Biological Process	GO:1904584	cellular response to polyamine macromolecule	Cdk4	IEP		Rat	PMID:21737690\|RGD:151893503
Biological Process	GO:0007623	circadian rhythm	Cdk4	IEP		Rat	PMID:11598123\|RGD:70761
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	CDK4	IDA		Human	PMID:19237565
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	CDK4	IMP		Human	PMID:7603984
Biological Process	GO:0002088	lens development in camera-type eye	Cdk4	IEP		Rat	PMID:10620399\|RGD:724665
Biological Process	GO:0043065	positive regulation of apoptotic process	Cdk4	IMP		Rat	PMID:18353414\|RGD:2293585
Biological Process	GO:0008284	positive regulation of cell population proliferation	CDK4	IMP		Human	PMID:7603984
Biological Process	GO:0008284	positive regulation of cell population proliferation	Cdk4	IMP		Rat	PMID:17635516\|RGD:1642396
Biological Process	GO:0045793	positive regulation of cell size	Cdk4	IMP		Rat	PMID:12163013\|RGD:704385
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Cdk4	IMP		Rat	PMID:21737690\|RGD:151893503
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	CDK4	IMP		Human	PMID:17420273
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	CDK4	IDA		Human	PMID:19124461
Biological Process	GO:0045727	positive regulation of translation	Cdk4	IMP		Rat	PMID:12163013\|RGD:704385
Biological Process	GO:0006468	protein phosphorylation	CDK4	IDA		Human	PMID:8114739
Biological Process	GO:0006468	protein phosphorylation	Cdk4	IDA		Mouse	PMID:12588994
Biological Process	GO:0006468	protein phosphorylation	Cdk4	IDA		Mouse	PMID:12124778
Biological Process	GO:0051726	regulation of cell cycle	CDK4	IDA		Human	PMID:19124461
Biological Process	GO:0051726	regulation of cell cycle	Cdk4	IDA		Mouse	PMID:12588994
Biological Process	GO:0010468	regulation of gene expression	CDK4	IMP		Human	PMID:17420273
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	Cdk4	IMP	MGI:MGI:2154521	Mouse	PMID:26657864
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	Cdk4	IMP	MGI:MGI:2154520	Mouse	PMID:26657864
Biological Process	GO:0046890	regulation of lipid biosynthetic process	Cdk4	IMP	MGI:MGI:2154520	Mouse	PMID:26657864
Biological Process	GO:0046890	regulation of lipid biosynthetic process	Cdk4	IMP	MGI:MGI:2154521	Mouse	PMID:26657864
Biological Process	GO:0050994	regulation of lipid catabolic process	Cdk4	IMP	MGI:MGI:2154521	Mouse	PMID:26657864
Biological Process	GO:0050994	regulation of lipid catabolic process	Cdk4	IMP	MGI:MGI:2154520	Mouse	PMID:26657864
Biological Process	GO:0040014	regulation of multicellular organism growth	Cdk4	IMP	MGI:MGI:2154520	Mouse	PMID:26657864
Biological Process	GO:0040014	regulation of multicellular organism growth	Cdk4	IMP	MGI:MGI:2154521	Mouse	PMID:26657864
Biological Process	GO:0061469	regulation of type B pancreatic cell proliferation	Cdk4	IMP	MGI:MGI:2154521	Mouse	PMID:12917627
Biological Process	GO:0061469	regulation of type B pancreatic cell proliferation	Cdk4	IMP	MGI:MGI:2154520	Mouse	PMID:12917627
Biological Process	GO:0055093	response to hyperoxia	Cdk4	IEP		Rat	PMID:18082050\|RGD:2289663
Biological Process	GO:0010288	response to lead ion	Cdk4	IMP		Rat	PMID:18353414\|RGD:2293585
Biological Process	GO:0010033	response to organic substance	Cdk4	IMP		Rat	PMID:18353414\|RGD:2293585
Biological Process	GO:0033574	response to testosterone	Cdk4	IDA		Rat	PMID:17962342\|RGD:2289135
Biological Process	GO:0009636	response to toxic substance	Cdk4	IEP		Rat	PMID:17343987\|RGD:2293565
Biological Process	GO:0009410	response to xenobiotic stimulus	CDK4	IEP		Human	PMID:18291362
Biological Process	GO:0007165	signal transduction	Cdk4	IDA		Mouse	PMID:12130539

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.