Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CDK5RAP2
  • Mouse genes Cdk5rap2
  • Rat genes Cdk5rap2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdk5rap2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005516	calmodulin binding	CDK5RAP2	IDA		Human	PMID:20466722
Molecular Function	GO:0043015	gamma-tubulin binding	CDK5RAP2	IDA		Human	PMID:29162697
Molecular Function	GO:0008017	microtubule binding	CDK5RAP2	IDA		Human	PMID:14654843
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:Q96CW5	Human	PMID:17959831
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:Q12834	Human	PMID:19282672
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:Q15691	Human	PMID:19553473
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:O95613	Human	PMID:20466722
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:Q99996	Human	PMID:20466722
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:Q76N32	Human	PMID:25503564
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:Q38SD2-1	Human	PMID:26192437
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:Q96R06	Human	PMID:26297806
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:Q9P209	Human	PMID:26297806
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:Q9HCH0	Human	PMID:26485573
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:P51654,UniProtKB:Q8N158,UniProtKB:Q9Y625	Human	PMID:29162697
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:Q08380	Human	PMID:29162697
Molecular Function	GO:0005515	protein binding	CDK5RAP2	IPI	UniProtKB:Q15691,UniProtKB:Q5VU43-13,UniProtKB:Q99996	Human	PMID:29162697
Molecular Function	GO:0005515	protein binding	Cdk5rap2	IPI	UniProtKB:P48725	Mouse	MGI:MGI:4454949|PMID:20471352
Molecular Function	GO:0019901	protein kinase binding	CDK5RAP2	IPI	UniProtKB:Q15078	Human	PMID:10721722
Molecular Function	GO:0044877	protein-containing complex binding	Cdk5rap2	IDA		Rat	PMID:10721722|RGD:632478
Molecular Function	GO:0000976	transcription cis-regulatory region binding	CDK5RAP2	IDA		Human	PMID:19282672
Molecular Function	GO:0015631	tubulin binding	CDK5RAP2	IPI	UniProtKB:P23258	Human	PMID:17959831
Cellular Component	GO:0030054	cell junction	CDK5RAP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	PMID:14654843
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	PMID:17959831
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	PMID:18042621
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	PMID:19282672
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	PMID:19543530
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	PMID:19553473
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	PMID:20466722
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	PMID:21399614
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	PMID:25657325
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	PMID:26485573
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	PMID:29162697
Cellular Component	GO:0005813	centrosome	CDK5RAP2	IDA		Human	PMID:31974111
Cellular Component	GO:0005813	centrosome	Cdk5rap2	IDA		Mouse	MGI:MGI:4454949|PMID:20471352
Cellular Component	GO:0005813	centrosome	Cdk5rap2	IDA		Mouse	MGI:MGI:4830038|PMID:20627074
Cellular Component	GO:0005813	centrosome	Cdk5rap2	IDA		Mouse	MGI:MGI:5883382|PMID:28057765
Cellular Component	GO:0005813	centrosome	Cdk5rap2	IDA		Mouse	PMID:17920017
Cellular Component	GO:0005813	centrosome	Cdk5rap2	IDA		Mouse	PMID:22179047
Cellular Component	GO:0005737	cytoplasm	CDK5RAP2	IDA		Human	PMID:17959831
Cellular Component	GO:0005737	cytoplasm	CDK5RAP2	IDA		Human	PMID:19282672
Cellular Component	GO:0005737	cytoplasm	CDK5RAP2	IDA		Human	PMID:19553473
Cellular Component	GO:0005829	cytosol	CDK5RAP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	CDK5RAP2	HDA		Human	PMID:19056867
Cellular Component	GO:0005794	Golgi apparatus	CDK5RAP2	IDA		Human	PMID:20466722
Cellular Component	GO:0005874	microtubule	CDK5RAP2	IDA		Human	PMID:19553473
Cellular Component	GO:0035371	microtubule plus-end	CDK5RAP2	IDA		Human	PMID:26485573
Cellular Component	GO:0097431	mitotic spindle pole	Cdk5rap2	IDA		Mouse	PMID:25220058
Cellular Component	GO:0000242	pericentriolar material	CDK5RAP2	IDA		Human	PMID:17959831
Cellular Component	GO:0048471	perinuclear region of cytoplasm	CDK5RAP2	IDA		Human	PMID:17959831
Cellular Component	GO:0000922	spindle pole	CDK5RAP2	IDA		Human	PMID:17959831
Cellular Component	GO:0000922	spindle pole	CDK5RAP2	IDA		Human	PMID:19282672
Biological Process	GO:0007420	brain development	Cdk5rap2	IMP		Mouse	MGI:MGI:4454588|PMID:20460369
Biological Process	GO:0007099	centriole replication	CDK5RAP2	IMP		Human	PMID:26297806
Biological Process	GO:0007098	centrosome cycle	CDK5RAP2	IMP		Human	PMID:18042621
Biological Process	GO:0007059	chromosome segregation	CDK5RAP2	IMP		Human	PMID:19282672
Biological Process	GO:0000132	establishment of mitotic spindle orientation	Cdk5rap2	IMP		Mouse	MGI:MGI:4454588|PMID:20460369
Biological Process	GO:0001578	microtubule bundle formation	CDK5RAP2	IDA		Human	PMID:19553473
Biological Process	GO:0000226	microtubule cytoskeleton organization	CDK5RAP2	IDA		Human	PMID:17959831
Biological Process	GO:0031023	microtubule organizing center organization	CDK5RAP2	IMP		Human	PMID:26485573
Biological Process	GO:0046600	negative regulation of centriole replication	Cdk5rap2	IMP		Mouse	MGI:MGI:4830038|PMID:20627074
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	Cdk5rap2	IDA		Rat	PMID:10721722|RGD:632478
Biological Process	GO:0045665	negative regulation of neuron differentiation	Cdk5rap2	IMP		Mouse	MGI:MGI:4454949|PMID:20471352
Biological Process	GO:0022008	neurogenesis	Cdk5rap2	IMP		Mouse	MGI:MGI:4454588|PMID:20460369
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CDK5RAP2	IDA		Human	PMID:19282672
Biological Process	GO:0031116	positive regulation of microtubule polymerization	CDK5RAP2	IMP		Human	PMID:29162697
Biological Process	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint	CDK5RAP2	IDA		Human	PMID:19282672

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern