Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CDK6
  • Mouse genes Cdk6
  • Rat genes Cdk6
  • Zfish genes cdk6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdk6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	CDK6	IDA		Human	PMID:9751050
Molecular Function	GO:0030332	cyclin binding	CDK6	IPI	UniProtKB:P24385	Human	PMID:8114739
Molecular Function	GO:0030332	cyclin binding	CDK6	IPI	UniProtKB:P30279	Human	PMID:8114739
Molecular Function	GO:0030332	cyclin binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:8114739
Molecular Function	GO:0030332	cyclin binding	Cdk6	IPI	RGD:2293	Rat	PMID:15809057|RGD:1582338
Molecular Function	GO:0030332	cyclin binding	Cdk6	IPI	RGD:621083	Rat	PMID:15809057|RGD:1582338
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	CDK6	IDA		Human	PMID:8114739
Molecular Function	GO:0098770	FBXO family protein binding	CDK6	IPI	UniProtKB:Q9Y3I1	Human	PMID:18495667
Molecular Function	GO:0016301	kinase activity	Cdk6	IDA		Mouse	PMID:21508411
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P24385	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P38936	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42771	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:Q01196	Human	PMID:17431401
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P24385	Human	PMID:17517622
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:17517622
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42771	Human	PMID:17909018
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42771	Human	PMID:17955473
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42773	Human	PMID:18394558
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:Q08050-1	Human	PMID:22094256
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42771	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42772	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42773	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P55273	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P24385	Human	PMID:24855949
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42771	Human	PMID:24855949
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:Q16543	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:Q01196	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42772	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42773	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P55273	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42773	Human	PMID:25502805
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42773	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42773	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P55273	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P38936	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42771	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42772	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42773	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P55273	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42773	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P55273	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P41238	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42772	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42773	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P51946	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P55273	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:Q14094	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:Q5XKR4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:Q9C019	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42771	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42772	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42773	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P30281	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42773	Human	PMID:8001816
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42772	Human	PMID:8078588
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P55273	Human	PMID:8741839
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42773	Human	PMID:8840966
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:Q16543	Human	PMID:9150368
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P42771	Human	PMID:9751050
Molecular Function	GO:0005515	protein binding	CDK6	IPI	UniProtKB:P55273	Human	PMID:9751050
Molecular Function	GO:0005515	protein binding	Cdk6	IPI	UniProtKB:P05627|UniProtKB:P30282|UniProtKB:P42227	Mouse	MGI:MGI:5514446|PMID:23948297
Molecular Function	GO:0005515	protein binding	Cdk6	IPI	UniProtKB:P30282	Mouse	MGI:MGI:5463835|PMID:23079656
Molecular Function	GO:0005515	protein binding	Cdk6	IPI	PR:Q9Z1L3	Mouse	PMID:21135503
Molecular Function	GO:0005515	protein binding	Cdk6	IPI	PR:Q3U7U3	Mouse	PMID:21652635
Molecular Function	GO:0005515	protein binding	Cdk6	IPI	UniProtKB:O89088	Mouse	PMID:7651726
Molecular Function	GO:0005515	protein binding	Cdk6	IPI	PR:P30280	Mouse	PMID:21652635
Cellular Component	GO:0005813	centrosome	CDK6	IDA		Human	PMID:23918663
Cellular Component	GO:0097132	cyclin D2-CDK6 complex	Cdk6	IDA		Mouse	PMID:7739547
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	CDK6	IDA		Human	PMID:17420273
Cellular Component	GO:0005737	cytoplasm	CDK6	IDA		Human	PMID:14985467
Cellular Component	GO:0005829	cytosol	CDK6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CDK6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CDK6	IDA		Human	PMID:14985467
Cellular Component	GO:0001726	ruffle	CDK6	IDA		Human	PMID:10205165
Biological Process	GO:0043697	cell dedifferentiation	CDK6	IMP		Human	PMID:12861051
Biological Process	GO:0044838	cell quiescence	Cdk6	IMP	MGI:MGI:3053975	Mouse	PMID:25342715
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	CDK6	IDA		Human	PMID:8114739
Biological Process	GO:0042063	gliogenesis	CDK6	IMP		Human	PMID:12861051
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Cdk6	IMP	MGI:MGI:5141514	Mouse	PMID:21508411
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Cdk6	IMP	MGI:MGI:3833563	Mouse	PMID:21508411
Biological Process	GO:0060218	hematopoietic stem cell differentiation	Cdk6	IMP	MGI:MGI:5141514	Mouse	PMID:21508411
Biological Process	GO:0060218	hematopoietic stem cell differentiation	Cdk6	IMP	MGI:MGI:3833563	Mouse	PMID:21508411
Biological Process	GO:0030097	hemopoiesis	Cdk6	IMP		Mouse	MGI:MGI:3053469|PMID:15315761
Biological Process	GO:0045786	negative regulation of cell cycle	CDK6	IDA		Human	PMID:14985467
Biological Process	GO:2000773	negative regulation of cellular senescence	CDK6	IDA		Human	PMID:17420273
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	CDK6	IMP		Human	PMID:14985467
Biological Process	GO:0045656	negative regulation of monocyte differentiation	CDK6	IDA		Human	PMID:26542173
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	CDK6	IDA		Human	PMID:17431401
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	CDK6	IDA		Human	PMID:15254224
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Cdk6	IMP	MGI:MGI:3053975	Mouse	PMID:25342715
Biological Process	GO:0007219	Notch signaling pathway	Cdk6	IGI	MGI:MGI:96549	Mouse	PMID:21508411
Biological Process	GO:0007219	Notch signaling pathway	Cdk6	IDA		Mouse	PMID:21508411
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	CDK6	IDA		Human	PMID:10205165
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	CDK6	IMP		Human	PMID:17420273
Biological Process	GO:0010628	positive regulation of gene expression	Cdk6	IDA		Mouse	PMID:21508411
Biological Process	GO:0006468	protein phosphorylation	CDK6	IDA		Human	PMID:8114739
Biological Process	GO:0045646	regulation of erythrocyte differentiation	CDK6	IMP		Human	PMID:12833137
Biological Process	GO:0010468	regulation of gene expression	CDK6	IDA		Human	PMID:15254224
Biological Process	GO:0010468	regulation of gene expression	CDK6	IMP		Human	PMID:17420273
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	Cdk6	IMP	MGI:MGI:3053975	Mouse	PMID:25342715
Biological Process	GO:0036275	response to 5-fluorouracil	Cdk6	IMP	MGI:MGI:3053975	Mouse	PMID:25342715
Biological Process	GO:0009615	response to virus	CDK6	IEP		Human	PMID:16548883
Biological Process	GO:0033077	T cell differentiation in thymus	Cdk6	IMP	MGI:MGI:3833563	Mouse	PMID:21508411
Biological Process	GO:0033077	T cell differentiation in thymus	Cdk6	IMP	MGI:MGI:5141514	Mouse	PMID:21508411
Biological Process	GO:0003323	type B pancreatic cell development	CDK6	IDA		Human	PMID:20668294

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern