Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CDK7
  • Mouse genes Cdk7
  • Rat genes Cdk7
  • Zfish genes cdk7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdk7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	CDK7	IDA		Human	PMID:9852112
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	Cdk7	IDA		Rat	PMID:8906616|RGD:1302419
Molecular Function	GO:0016301	kinase activity	Cdk7	IDA		Mouse	PMID:11319144
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:P51948	Human	PMID:10801852
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:P49773	Human	PMID:10958787
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:P24941	Human	PMID:15530371
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:O00267	Human	PMID:16327805
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:P11802	Human	PMID:16327805
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:P24941	Human	PMID:16327805
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:P51946,UniProtKB:P56545	Human	PMID:23393140
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:P24941	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:P78362	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:Q96SB4	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:P08238	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:P78362	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDK7	IPI	UniProtKB:Q96SB4	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Cdk7	IPI	PR:P51949	Mouse	PMID:17276355
Molecular Function	GO:0004672	protein kinase activity	Cdk7	IDA		Mouse	PMID:12748294
Molecular Function	GO:0044877	protein-containing complex binding	Cdk7	IDA		Rat	PMID:7885450|RGD:2313496
Molecular Function	GO:0044877	protein-containing complex binding	Cdk7	IDA		Rat	PMID:9891058|RGD:2313485
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	CDK7	IDA		Human	PMID:12721286
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	CDK7	IDA		Human	PMID:9852112
Cellular Component	GO:0070516	CAK-ERCC2 complex	CDK7	IDA		Human	PMID:8692841
Cellular Component	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	CDK7	IDA		Human	PMID:23622515
Cellular Component	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	CDK7	IMP		Human	PMID:23393140
Cellular Component	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	CDK7	IDA		Human	PMID:8692841
Cellular Component	GO:0005856	cytoskeleton	Cdk7	IDA		Rat	PMID:15886195|RGD:2313484
Cellular Component	GO:0005829	cytosol	CDK7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Cdk7	IDA		Rat	PMID:15886195|RGD:2313484
Cellular Component	GO:0001650	fibrillar center	CDK7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001673	male germ cell nucleus	Cdk7	IDA		Mouse	PMID:11319144
Cellular Component	GO:0016020	membrane	Cdk7	IDA		Rat	PMID:15886195|RGD:2313484
Cellular Component	GO:0005654	nucleoplasm	CDK7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CDK7	IDA		Human	PMID:10958787
Cellular Component	GO:0005634	nucleus	CDK7	IDA		Human	PMID:16109376
Cellular Component	GO:0005634	nucleus	Cdk7	IDA		Rat	PMID:15886195|RGD:2313484
Cellular Component	GO:0005886	plasma membrane	CDK7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000439	transcription factor TFIIH core complex	CDK7	IDA		Human	PMID:8692841
Cellular Component	GO:0005675	transcription factor TFIIH holo complex	CDK7	IDA		Human	PMID:9852112
Cellular Component	GO:0005675	transcription factor TFIIH holo complex	Cdk7	IDA		Rat	PMID:7553866|RGD:9590319
Cellular Component	GO:0070985	transcription factor TFIIK complex	CDK7	IDA		Human	PMID:8692841
Biological Process	GO:0006468	protein phosphorylation	Cdk7	IDA		Rat	PMID:8906616|RGD:1302419
Biological Process	GO:0050821	protein stabilization	CDK7	IMP		Human	PMID:23393140
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	CDK7	IDA		Human	PMID:23622515
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	CDK7	IDA		Human	PMID:23622515
Biological Process	GO:0006366	transcription by RNA polymerase II	CDK7	IDA		Human	PMID:8692841
Biological Process	GO:0006366	transcription by RNA polymerase II	CDK7	IDA		Human	PMID:9852112
Biological Process	GO:0006366	transcription by RNA polymerase II	Cdk7	IDA		Rat	PMID:7553866|RGD:9590319
Biological Process	GO:0006367	transcription initiation at RNA polymerase II promoter	CDK7	IDA		Human	PMID:7533895

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern