Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CDKL5
  • Mouse genes Cdkl5
  • Rat genes Cdkl5
  • Zfish genes cdkl5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdkl5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	CDKL5	IDA		Human	PMID:16935860
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	cdkl5	IDA		Zfish	PMID:26927518
Molecular Function	GO:0016301	kinase activity	CDKL5	IDA		Human	PMID:15917271
Molecular Function	GO:0005515	protein binding	CDKL5	IPI	UniProtKB:P40692	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	CDKL5	IPI	UniProtKB:P40692	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKL5	IPI	UniProtKB:Q08379	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Cdkl5	IPI	RGD:68424	Rat	PMID:23671101|RGD:12791021
Molecular Function	GO:0004672	protein kinase activity	CDKL5	IDA		Human	PMID:16935860
Molecular Function	GO:0031267	small GTPase binding	Cdkl5	IPI	UniProtKB:Q6RUV5	Rat	PMID:20861382|RGD:8554575
Cellular Component	GO:0005813	centrosome	CDKL5	IDA		Human	PMID:29420175
Cellular Component	GO:0036064	ciliary basal body	CDKL5	IDA		Human	PMID:29420175
Cellular Component	GO:0097542	ciliary tip	CDKL5	IDA		Human	PMID:29420175
Cellular Component	GO:0005737	cytoplasm	cdkl5	IDA		Zfish	PMID:26927518
Cellular Component	GO:0032839	dendrite cytoplasm	Cdkl5	IDA		Rat	PMID:20861382|RGD:8554575
Cellular Component	GO:0044294	dendritic growth cone	Cdkl5	IDA		Rat	PMID:20861382|RGD:8554575
Cellular Component	GO:0098978	glutamatergic synapse	CDKL5	IDA		Human	PMID:22922712
Cellular Component	GO:0098978	glutamatergic synapse	CDKL5	IMP		Human	PMID:22922712
Cellular Component	GO:0098978	glutamatergic synapse	Cdkl5	IDA		Rat	PMID:23671101|RGD:12791021
Cellular Component	GO:0005654	nucleoplasm	CDKL5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CDKL5	IDA		Human	PMID:16935860
Cellular Component	GO:0005634	nucleus	cdkl5	IDA		Zfish	PMID:26927518
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Cdkl5	IDA		Rat	PMID:23671101|RGD:12791021
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Cdkl5	IDA		Rat	PMID:23671101|RGD:12791021
Cellular Component	GO:0032587	ruffle membrane	Cdkl5	IDA		Rat	PMID:20861382|RGD:8554575
Cellular Component	GO:0045202	synapse	Cdkl5	IDA		Rat	PMID:23671101|RGD:12791021
Biological Process	GO:0030282	bone mineralization	cdkl5	IMP	ZFIN:ZDB-GENO-221003-1	Zfish	PMID:35665761
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	cdkl5	IMP	ZFIN:ZDB-GENO-221003-2	Zfish	PMID:35665761
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	cdkl5	IMP	ZFIN:ZDB-GENO-221003-1	Zfish	PMID:35665761
Biological Process	GO:0050804	modulation of chemical synaptic transmission	CDKL5	IDA		Human	PMID:22922712
Biological Process	GO:0050804	modulation of chemical synaptic transmission	CDKL5	IMP		Human	PMID:22922712
Biological Process	GO:0061744	motor behavior	cdkl5	IMP	ZFIN:ZDB-GENO-221003-1	Zfish	PMID:35665761
Biological Process	GO:0061744	motor behavior	cdkl5	IMP	ZFIN:ZDB-GENO-221003-2	Zfish	PMID:35665761
Biological Process	GO:0001764	neuron migration	Cdkl5	IMP		Rat	PMID:20861382|RGD:8554575
Biological Process	GO:0045773	positive regulation of axon extension	Cdkl5	IMP		Rat	PMID:20861382|RGD:8554575
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Cdkl5	IMP		Rat	PMID:20861382|RGD:8554575
Biological Process	GO:0060999	positive regulation of dendritic spine development	Cdkl5	IMP		Rat	PMID:23671101|RGD:12791021
Biological Process	GO:0043547	positive regulation of GTPase activity	Cdkl5	IMP		Rat	PMID:20861382|RGD:8554575
Biological Process	GO:0046777	protein autophosphorylation	CDKL5	IDA		Human	PMID:16935860
Biological Process	GO:0034504	protein localization to nucleus	Cdkl5	IMP	MGI:MGI:5573238	Mouse	PMID:27466189
Biological Process	GO:1902017	regulation of cilium assembly	CDKL5	IMP		Human	PMID:29420175
Biological Process	GO:0050773	regulation of dendrite development	Cdkl5	IMP		Rat	PMID:20861382|RGD:8554575
Biological Process	GO:0099175	regulation of postsynapse organization	CDKL5	IDA		Human	PMID:22922712
Biological Process	GO:0099175	regulation of postsynapse organization	CDKL5	IMP		Human	PMID:22922712
Biological Process	GO:0036269	swimming behavior	cdkl5	IMP	ZFIN:ZDB-GENO-221003-1	Zfish	PMID:35665761
Biological Process	GO:0036269	swimming behavior	cdkl5	IMP	ZFIN:ZDB-GENO-221003-2	Zfish	PMID:35665761

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern