Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CDKN2A
  • Mouse genes Cdkn2a
  • Rat genes Cdkn2a
  • Zfish genes cdkn2a/b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdkn2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	CDKN2A	IDA		Human	PMID:7739547
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	CDKN2A	IDA		Human	PMID:8259215
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	Cdkn2a	IDA		Mouse	PMID:12130539
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	Cdkn2a	IDA		Mouse	PMID:7651726
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	Cdkn2a	IPI	UniProtKB:Q00987	Mouse	MGI:MGI:2153973|PMID:11718560
Molecular Function	GO:0051059	NF-kappaB binding	CDKN2A	IDA		Human	PMID:10353611
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q96SB3	Human	PMID:11278317
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:O75496	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P11802	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q00534	Human	PMID:15232106
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P11802	Human	PMID:17517622
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q96AB3	Human	PMID:17658461
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P11802	Human	PMID:17909018
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q00534	Human	PMID:17909018
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P11802	Human	PMID:17955473
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P12004	Human	PMID:17955473
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q00534	Human	PMID:17955473
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q14566	Human	PMID:17955473
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P51532	Human	PMID:19149898
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:O75398	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q00839	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q6UXH1	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q8NHU6	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P11802	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P11802	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q00534	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P11802	Human	PMID:24855949
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q00534	Human	PMID:24855949
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P11802	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P11802	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:O75496	Human	PMID:27229929
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P11802	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q00534	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:P11802	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q00534	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDKN2A	IPI	UniProtKB:Q00534	Human	PMID:9751050
Molecular Function	GO:0005515	protein binding	Cdkn2a	IPI	UniProtKB:Q8VCI5	Mouse	MGI:MGI:3828414|PMID:11259404
Molecular Function	GO:0005515	protein binding	Cdkn2a	IPI	UniProtKB:P06748	Mouse	MGI:MGI:6467679|PMID:16540653
Molecular Function	GO:0005515	protein binding	Cdkn2a	IPI	UniProtKB:Q8K4B0	Mouse	MGI:MGI:5002370|PMID:21555589
Molecular Function	GO:0005515	protein binding	Cdkn2a	IPI	UniProtKB:Q07021	Mouse	MGI:MGI:5447611|PMID:17486078
Molecular Function	GO:0005515	protein binding	Cdkn2a	IPI	PR:Q61937	Mouse	PMID:24616519
Molecular Function	GO:0005515	protein binding	Cdkn2a	IPI	PR:P01108	Mouse	PMID:23277542
Molecular Function	GO:0005515	protein binding	Cdkn2a	IPI	PR:P41183	Mouse	PMID:15567177
Molecular Function	GO:0005515	protein binding	Cdkn2a	IPI	PR:Q61937	Mouse	PMID:15485902
Molecular Function	GO:0005515	protein binding	Cdkn2a	IPI	PR:P23804	Mouse	PMID:15485902
Molecular Function	GO:0005515	protein binding	Cdkn2a	IPI	PR:P23804	Mouse	PMID:15989966
Molecular Function	GO:0019901	protein kinase binding	CDKN2A	IPI	UniProtKB:P11802	Human	PMID:8259215
Molecular Function	GO:0003723	RNA binding	CDKN2A	HDA		Human	PMID:22681889
Molecular Function	GO:0055105	ubiquitin-protein transferase inhibitor activity	Cdkn2a	IDA		Mouse	MGI:MGI:1327100|PMID:9878046
Cellular Component	GO:0005737	cytoplasm	CDKN2A	IDA		Human	PMID:16243918
Cellular Component	GO:0005737	cytoplasm	Cdkn2a	IDA		Mouse	PMID:12154087
Cellular Component	GO:0005737	cytoplasm	Cdkn2a	IDA		Rat	PMID:24069379|RGD:11252091
Cellular Component	GO:0001652	granular component	Cdkn2a	IDA		Mouse	MGI:MGI:2387903|PMID:12154087
Cellular Component	GO:0005730	nucleolus	Cdkn2a	IDA		Mouse	PMID:15567177
Cellular Component	GO:0005730	nucleolus	Cdkn2a	IDA		Mouse	PMID:15485902
Cellular Component	GO:0005730	nucleolus	Cdkn2a	IDA		Mouse	PMID:11718560
Cellular Component	GO:0005730	nucleolus	Cdkn2a	IDA		Mouse	PMID:16199867
Cellular Component	GO:0005730	nucleolus	Cdkn2a	IDA		Mouse	PMID:18625840
Cellular Component	GO:0005730	nucleolus	Cdkn2a	IDA		Mouse	PMID:15989966
Cellular Component	GO:0005634	nucleus	CDKN2A	IDA		Human	PMID:16243918
Cellular Component	GO:0005634	nucleus	Cdkn2a	IDA		Rat	PMID:16317707|RGD:1600816
Cellular Component	GO:0032991	protein-containing complex	Cdkn2a	IMP		Mouse	MGI:MGI:2153973|PMID:11718560
Cellular Component	GO:0035985	senescence-associated heterochromatin focus	CDKN2A	IDA		Human	PMID:16901784
Biological Process	GO:0007568	aging	Cdkn2a	IEP		Rat	PMID:15520862|RGD:1358479
Biological Process	GO:0060057	apoptotic process involved in mammary gland involution	Cdkn2a	IMP	MGI:MGI:1926877	Mouse	PMID:15105443
Biological Process	GO:0007049	cell cycle	Cdkn2a	IDA		Mouse	PMID:15485902
Biological Process	GO:0071333	cellular response to glucose stimulus	Cdkn2a	IEP		Rat	PMID:20943765|RGD:11252096
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Cdkn2a	IDA		Mouse	PMID:20808772
Biological Process	GO:0090398	cellular senescence	CDKN2A	IMP		Human	PMID:16243918
Biological Process	GO:0090398	cellular senescence	Cdkn2a	IMP		Mouse	PMID:21911473
Biological Process	GO:0090398	cellular senescence	Cdkn2a	IGI	MGI:MGI:104556	Mouse	PMID:11551927
Biological Process	GO:0090398	cellular senescence	Cdkn2a	IDA		Mouse	PMID:22729085
Biological Process	GO:0090398	cellular senescence	Cdkn2a	IDA		Mouse	PMID:11748239
Biological Process	GO:0021549	cerebellum development	Cdkn2a	IEP		Rat	PMID:9693786|RGD:8552681
Biological Process	GO:0008544	epidermis development	Cdkn2a	IMP	MGI:MGI:1857942	Mouse	PMID:11551927
Biological Process	GO:0008544	epidermis development	Cdkn2a	IGI	MGI:MGI:104556	Mouse	PMID:11551927
Biological Process	GO:0042593	glucose homeostasis	Cdkn2a	IMP	MGI:MGI:1926877	Mouse	PMID:22952318
Biological Process	GO:0042593	glucose homeostasis	Cdkn2a	IMP	MGI:MGI:1857942	Mouse	PMID:22952318
Biological Process	GO:0030216	keratinocyte differentiation	Cdkn2a	IGI	MGI:MGI:104556	Mouse	PMID:11551927
Biological Process	GO:0043616	keratinocyte proliferation	Cdkn2a	IGI	MGI:MGI:104556	Mouse	PMID:11551927
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	Cdkn2a	IMP	MGI:MGI:1926877	Mouse	PMID:15105443
Biological Process	GO:0030889	negative regulation of B cell proliferation	Cdkn2a	IMP		Mouse	MGI:MGI:3615850|PMID:15964995
Biological Process	GO:0045786	negative regulation of cell cycle	Cdkn2a	IDA		Mouse	PMID:15485902
Biological Process	GO:0030308	negative regulation of cell growth	CDKN2A	IDA		Human	PMID:10208428
Biological Process	GO:0030308	negative regulation of cell growth	Cdkn2a	IMP		Mouse	MGI:MGI:2387903|PMID:12154087
Biological Process	GO:0008285	negative regulation of cell population proliferation	CDKN2A	IDA		Human	PMID:15149599
Biological Process	GO:0008285	negative regulation of cell population proliferation	CDKN2A	IMP		Human	PMID:16243918
Biological Process	GO:0008285	negative regulation of cell population proliferation	CDKN2A	IMP		Human	PMID:16901784
Biological Process	GO:0008285	negative regulation of cell population proliferation	CDKN2A	IMP		Human	PMID:7603984
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	CDKN2A	IMP		Human	PMID:10205165
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	CDKN2A	IDA		Human	PMID:7739547
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	CDKN2A	IDA		Human	PMID:8259215
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	Cdkn2a	IDA		Mouse	PMID:12130539
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	CDKN2A	IMP		Human	PMID:16901784
Biological Process	GO:2000346	negative regulation of hepatocyte proliferation	Cdkn2a	IMP		Rat	PMID:24190239|RGD:11252157
Biological Process	GO:0033088	negative regulation of immature T cell proliferation in thymus	Cdkn2a	IMP		Mouse	MGI:MGI:3615850|PMID:15964995
Biological Process	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	Cdkn2a	IMP	MGI:MGI:1926877	Mouse	PMID:15105443
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	CDKN2A	IDA		Human	PMID:10353611
Biological Process	GO:0042326	negative regulation of phosphorylation	CDKN2A	IDA		Human	PMID:10208428
Biological Process	GO:0042326	negative regulation of phosphorylation	CDKN2A	IDA		Human	PMID:8259215
Biological Process	GO:0032091	negative regulation of protein binding	Cdkn2a	IDA		Mouse	PMID:23277542
Biological Process	GO:1903051	negative regulation of proteolysis involved in protein catabolic process	Cdkn2a	IDA		Mouse	PMID:23277542
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	Cdkn2a	IDA		Mouse	PMID:23277542
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	Cdkn2a	IDA		Mouse	MGI:MGI:1327100|PMID:9878046
Biological Process	GO:0022008	neurogenesis	Cdkn2a	IEP		Rat	PMID:19114593|RGD:11252093
Biological Process	GO:0090402	oncogene-induced cell senescence	Cdkn2a	IMP	MGI:MGI:1857942	Mouse	PMID:11551927
Biological Process	GO:0090402	oncogene-induced cell senescence	Cdkn2a	IGI	MGI:MGI:104556	Mouse	PMID:11551927
Biological Process	GO:0043065	positive regulation of apoptotic process	Cdkn2a	IMP		Rat	PMID:22020338|RGD:8552661
Biological Process	GO:0060058	positive regulation of apoptotic process involved in mammary gland involution	Cdkn2a	IMP	MGI:MGI:1926877	Mouse	PMID:15105443
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Cdkn2a	IMP		Mouse	MGI:MGI:3830454|PMID:19057511
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Cdkn2a	IMP		Mouse	MGI:MGI:3830454|PMID:19057511
Biological Process	GO:2000111	positive regulation of macrophage apoptotic process	Cdkn2a	IGI	UniProtKB:P08226	Mouse	MGI:MGI:4943829|PMID:20381282
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	Cdkn2a	IGI	UniProtKB:P08226	Mouse	MGI:MGI:4943829|PMID:20381282
Biological Process	GO:0007265	Ras protein signal transduction	CDKN2A	IEP		Human	PMID:9054499
Biological Process	GO:0051726	regulation of cell cycle	CDKN2A	IDA		Human	PMID:15149599
Biological Process	GO:0051726	regulation of cell cycle	CDKN2A	IMP		Human	PMID:16243918
Biological Process	GO:0051726	regulation of cell cycle	Cdkn2a	IDA		Mouse	PMID:7651726
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	Cdkn2a	IDA		Mouse	PMID:7651726
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	Cdkn2a	IGI	MGI:MGI:2182269	Mouse	PMID:12154087
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	CDKN2A	IDA		Human	PMID:10208428
Biological Process	GO:0010468	regulation of gene expression	Cdkn2a	IMP	MGI:MGI:1926877	Mouse	PMID:11438662
Biological Process	GO:0046822	regulation of nucleocytoplasmic transport	Cdkn2a	IGI	MGI:MGI:106184	Mouse	PMID:15485902
Biological Process	GO:0031647	regulation of protein stability	Cdkn2a	IMP		Mouse	MGI:MGI:2387903|PMID:12154087
Biological Process	GO:0090399	replicative senescence	CDKN2A	IMP		Human	PMID:14720514
Biological Process	GO:0061771	response to caloric restriction	Cdkn2a	IEP		Rat	PMID:15520862|RGD:1358479
Biological Process	GO:0070542	response to fatty acid	Cdkn2a	IEP		Rat	PMID:22395468|RGD:11252094
Biological Process	GO:0014070	response to organic cyclic compound	Cdkn2a	IDA		Rat	PMID:18204080|RGD:2289691
Biological Process	GO:0010033	response to organic substance	Cdkn2a	IEP		Rat	PMID:17761140|RGD:2289694
Biological Process	GO:0010243	response to organonitrogen compound	Cdkn2a	IDA		Rat	PMID:17920094|RGD:2289693
Biological Process	GO:0009651	response to salt stress	Cdkn2a	IEP		Rat	PMID:19826180|RGD:11252108
Biological Process	GO:0009410	response to xenobiotic stimulus	Cdkn2a	IEP		Rat	PMID:12189186|RGD:1600823
Biological Process	GO:0009410	response to xenobiotic stimulus	Cdkn2a	IDA		Rat	PMID:17706854|RGD:2316084
Biological Process	GO:0009303	rRNA transcription	Cdkn2a	IGI	MGI:MGI:98834	Mouse	PMID:18809582
Biological Process	GO:0048103	somatic stem cell division	Cdkn2a	IMP		Mouse	MGI:MGI:3615850|PMID:15964995
Biological Process	GO:0035019	somatic stem cell population maintenance	Cdkn2a	IGI	MGI:MGI:101761	Mouse	PMID:18957199

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern