Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CDKN2B
  • Mouse genes Cdkn2b
  • Rat genes Cdkn2b
  • Zfish genes cdkn2a/b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdkn2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	CDKN2B	IDA		Human	PMID:8078588
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P43364	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:19447967
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:21900206
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q00534	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q00534	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q13077	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q9GZT8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q00534	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:A6ZKI3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P24863	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P43364	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q00534	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q00537	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q0VD86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q13077	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q53H96	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q6P9H4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q9BVN2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q9NZD8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q9UI12	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CDKN2B	IPI	UniProtKB:Q00534	Human	PMID:32707033
Molecular Function	GO:0019901	protein kinase binding	CDKN2B	IPI	UniProtKB:P11802	Human	PMID:8078588
Molecular Function	GO:0019901	protein kinase binding	CDKN2B	IPI	UniProtKB:Q00534	Human	PMID:8078588
Cellular Component	GO:0005737	cytoplasm	CDKN2B	IDA		Human	PMID:16943770
Cellular Component	GO:0005737	cytoplasm	CDKN2B	IDA		Human	PMID:9230210
Cellular Component	GO:0005634	nucleus	CDKN2B	IDA		Human	PMID:18564286
Cellular Component	GO:0005634	nucleus	CDKN2B	IDA		Human	PMID:9230210
Cellular Component	GO:0005634	nucleus	Cdkn2b	IDA		Rat	PMID:11509832|RGD:7248762
Biological Process	GO:0007568	aging	Cdkn2b	IEP		Rat	PMID:21147108|RGD:7248759
Biological Process	GO:0031668	cellular response to extracellular stimulus	CDKN2B	IMP		Human	PMID:17553787
Biological Process	GO:0031670	cellular response to nutrient	CDKN2B	IMP		Human	PMID:17597576
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Cdkn2b	IEP		Rat	PMID:11369440|RGD:11252200
Biological Process	GO:0090398	cellular senescence	CDKN2B	IMP		Human	PMID:17553787
Biological Process	GO:0001889	liver development	Cdkn2b	IEP		Rat	PMID:11042273|RGD:7248763
Biological Process	GO:0030219	megakaryocyte differentiation	CDKN2B	IEP		Human	PMID:10812241
Biological Process	GO:1902807	negative regulation of cell cycle G1/S phase transition	Cdkn2b	IMP		Rat	PMID:26526028|RGD:11252201
Biological Process	GO:0008285	negative regulation of cell population proliferation	CDKN2B	IMP		Human	PMID:17553787
Biological Process	GO:0008285	negative regulation of cell population proliferation	Cdkn2b	IMP		Rat	PMID:7546221|RGD:728264
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	CDKN2B	IMP		Human	PMID:16943770
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	Cdkn2b	IMP		Mouse	PMID:23154982
Biological Process	GO:0060253	negative regulation of glial cell proliferation	Cdkn2b	IMP		Rat	PMID:26526028|RGD:11252201
Biological Process	GO:0042326	negative regulation of phosphorylation	CDKN2B	IDA		Human	PMID:8078588
Biological Process	GO:0030858	positive regulation of epithelial cell differentiation	Cdkn2b	IEP		Rat	PMID:17158884|RGD:2289700
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	CDKN2B	IMP		Human	PMID:16943770
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	CDKN2B	IDA		Human	PMID:8078588
Biological Process	GO:0070316	regulation of G0 to G1 transition	CDKN2B	IMP		Human	PMID:17553787
Biological Process	GO:0034097	response to cytokine	Cdkn2b	IEP		Rat	PMID:15333329|RGD:2289701
Biological Process	GO:0014070	response to organic cyclic compound	Cdkn2b	IEP		Rat	PMID:11513834|RGD:2289702
Biological Process	GO:0048536	spleen development	Cdkn2b	IGI	MGI:MGI:97495	Mouse	PMID:22560297
Biological Process	GO:0048536	spleen development	Cdkn2b	IGI	MGI:MGI:97350	Mouse	PMID:22560297

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern