Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CDX2
  • Mouse genes Cdx2
  • Rat genes Cdx2
  • Zfish genes cdx1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cdx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Cdx2	IDA		Mouse	MGI:MGI:5301472|PMID:22015720
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Cdx2	IDA		Mouse	PMID:16325584
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Cdx2	IDA		Rat	PMID:12223343|RGD:625733
Molecular Function	GO:0003700	DNA-binding transcription factor activity	cdx1b	IPI	ZFIN:ZDB-GENE-980526-404	Zfish	PMID:18234726
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	CDX2	IDA		Human	PMID:15677472
Molecular Function	GO:0003690	double-stranded DNA binding	Cdx2	IDA		Rat	PMID:12223343|RGD:625733
Molecular Function	GO:0008327	methyl-CpG binding	CDX2	IDA		Human	PMID:28473536
Molecular Function	GO:1990841	promoter-specific chromatin binding	cdx1b	IDA		Zfish	PMID:33197427
Molecular Function	GO:0005515	protein binding	CDX2	IPI	UniProtKB:Q8IYR0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CDX2	IPI	UniProtKB:Q9BQ66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Cdx2	IPI	PR:P20263	Mouse	PMID:16325584
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	CDX2	IDA		Human	PMID:15677472
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Cdx2	IDA		Mouse	MGI:MGI:6695858|PMID:9933478
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Cdx2	IDA		Mouse	MGI:MGI:6695963|PMID:9512360
Molecular Function	GO:0043565	sequence-specific DNA binding	Cdx2	IDA		Mouse	PMID:19796622
Molecular Function	GO:0043565	sequence-specific DNA binding	cdx1b	IPI	ZFIN:ZDB-GENE-980526-404	Zfish	PMID:18234726
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	CDX2	IDA		Human	PMID:28473536
Cellular Component	GO:0000794	condensed nuclear chromosome	Cdx2	IDA		Mouse	PMID:15509711
Cellular Component	GO:0005654	nucleoplasm	CDX2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:23824537
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:25397698
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:22573614
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:24315442
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:24268575
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:22948967
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:22529382
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:20676102
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:21530438
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:24036311
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:18423437
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:16325584
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:19796622
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Mouse	PMID:17138661
Cellular Component	GO:0005634	nucleus	Cdx2	IDA		Rat	PMID:22184114|RGD:10047257
Cellular Component	GO:0032991	protein-containing complex	Cdx2	IDA		Mouse	PMID:19796622
Cellular Component	GO:0017053	transcription repressor complex	Cdx2	IDA		Mouse	PMID:16325584
Biological Process	GO:0009952	anterior/posterior pattern specification	Cdx2	IGI	MGI:MGI:88362	Mouse	PMID:19853565
Biological Process	GO:0001824	blastocyst development	Cdx2	IMP	MGI:MGI:1857928	Mouse	PMID:15788452
Biological Process	GO:0001568	blood vessel development	Cdx2	IGI	MGI:MGI:88362	Mouse	PMID:16396910
Biological Process	GO:0035462	determination of left/right asymmetry in diencephalon	cdx1b	IMP	ZFIN:ZDB-GENO-220527-3	Zfish	PMID:33197427
Biological Process	GO:0048565	digestive tract development	cdx1b	IMP	ZFIN:ZDB-MRPHLNO-080707-1	Zfish	PMID:19253392
Biological Process	GO:0048546	digestive tract morphogenesis	cdx1b	IMP	ZFIN:ZDB-MRPHLNO-090217-1	Zfish	PMID:18804112
Biological Process	GO:0048546	digestive tract morphogenesis	cdx1b	IMP	ZFIN:ZDB-MRPHLNO-090217-2	Zfish	PMID:18804112
Biological Process	GO:0048546	digestive tract morphogenesis	cdx1b	IMP	ZFIN:ZDB-MRPHLNO-080707-1	Zfish	PMID:18234726
Biological Process	GO:0001706	endoderm formation	cdx1b	IMP	ZFIN:ZDB-MRPHLNO-080707-1	Zfish	PMID:18234726
Biological Process	GO:0008333	endosome to lysosome transport	Cdx2	IMP		Mouse	PMID:20551175
Biological Process	GO:0030855	epithelial cell differentiation	cdx1b	IMP	ZFIN:ZDB-MRPHLNO-090217-1	Zfish	PMID:18804112
Biological Process	GO:0050673	epithelial cell proliferation	cdx1b	IMP	ZFIN:ZDB-MRPHLNO-090217-1	Zfish	PMID:18804112
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	Cdx2	IMP	MGI:MGI:3848929	Mouse	PMID:20551175
Biological Process	GO:0060575	intestinal epithelial cell differentiation	Cdx2	IMP		Mouse	MGI:MGI:5301472|PMID:22015720
Biological Process	GO:0060575	intestinal epithelial cell differentiation	cdx1b	IMP	ZFIN:ZDB-MRPHLNO-080707-1	Zfish	PMID:19253392
Biological Process	GO:0060711	labyrinthine layer development	Cdx2	IGI	MGI:MGI:88362	Mouse	PMID:19853565
Biological Process	GO:0001889	liver development	cdx1b	IMP	ZFIN:ZDB-MRPHLNO-080707-1	Zfish	PMID:18234726
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	CDX2	IDA		Human	PMID:15677472
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Cdx2	IDA		Mouse	PMID:16325584
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Cdx2	IGI	MGI:MGI:101893	Mouse	PMID:16325584
Biological Process	GO:0031016	pancreas development	cdx1b	IMP	ZFIN:ZDB-MRPHLNO-080707-1	Zfish	PMID:18234726
Biological Process	GO:0007389	pattern specification process	Cdx2	IMP	MGI:MGI:1857928	Mouse	PMID:11959827
Biological Process	GO:0001890	placenta development	Cdx2	IGI	MGI:MGI:88362	Mouse	PMID:16396910
Biological Process	GO:0045597	positive regulation of cell differentiation	Cdx2	IMP	MGI:MGI:5308967	Mouse	PMID:22190642
Biological Process	GO:0045597	positive regulation of cell differentiation	Cdx2	IDA		Mouse	PMID:16325584
Biological Process	GO:0008284	positive regulation of cell population proliferation	Cdx2	IDA		Rat	PMID:12223343|RGD:625733
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Cdx2	IDA		Rat	PMID:12223343|RGD:625733
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	cdx1b	IGI	ZFIN:ZDB-GENE-980526-404	Zfish	PMID:18234726
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Cdx2	IDA		Mouse	MGI:MGI:6695963|PMID:9512360
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Cdx2	IDA		Mouse	MGI:MGI:6695858|PMID:9933478
Biological Process	GO:0014807	regulation of somitogenesis	Cdx2	IMP		Mouse	MGI:MGI:5301472|PMID:22015720
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Cdx2	IDA		Mouse	PMID:19796622
Biological Process	GO:0035019	somatic stem cell population maintenance	Cdx2	IMP	MGI:MGI:1857928	Mouse	PMID:20404091
Biological Process	GO:0035019	somatic stem cell population maintenance	Cdx2	IMP		Mouse	PMID:16325584
Biological Process	GO:0048863	stem cell differentiation	Cdx2	IMP	MGI:MGI:1857928	Mouse	PMID:20404091
Biological Process	GO:0001829	trophectodermal cell differentiation	Cdx2	IDA		Mouse	PMID:25397698
Biological Process	GO:0001829	trophectodermal cell differentiation	Cdx2	IMP	MGI:MGI:1857928	Mouse	PMID:20404091
Biological Process	GO:0001829	trophectodermal cell differentiation	Cdx2	IDA		Mouse	PMID:16325584
Biological Process	GO:0001829	trophectodermal cell differentiation	Cdx2	IMP		Mouse	PMID:25397698
Biological Process	GO:0001829	trophectodermal cell differentiation	Cdx2	IMP	MGI:MGI:1857928	Mouse	PMID:15788452

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern