Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CEACAM1,CEACAM5,CEACAM6,PSG1,PSG3,PSG4,PSG6,PSG7,PSG8,PSG9
  • Mouse genes Ceacam2
  • Rat genes Ceacam1
  • Zfish genes si:ch211-213a13.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ceacam2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	CEACAM1	IPI	UniProtKB:P60709	Human	PMID:17192268
Molecular Function	GO:0015125	bile acid transmembrane transporter activity	Ceacam1	IDA		Rat	PMID:7518458|RGD:11059589
Molecular Function	GO:0005516	calmodulin binding	Ceacam1	IDA		Rat	PMID:8576129|RGD:11059582
Molecular Function	GO:0031005	filamin binding	CEACAM1	IPI	UniProtKB:P21333	Human	PMID:16291724
Molecular Function	GO:0034235	GPI anchor binding	CEACAM5	IMP		Human	PMID:10931872
Molecular Function	GO:0042802	identical protein binding	CEACAM5	IPI	UniProtKB:P06731	Human	PMID:10864933
Molecular Function	GO:0042802	identical protein binding	CEACAM5	IPI	UniProtKB:P06731	Human	PMID:18086185
Molecular Function	GO:0042802	identical protein binding	CEACAM5	IDA		Human	PMID:26483485
Molecular Function	GO:0042802	identical protein binding	CEACAM5	IPI	UniProtKB:P06731	Human	PMID:26483485
Molecular Function	GO:0042802	identical protein binding	CEACAM1	IPI	UniProtKB:P13688	Human	PMID:19948502
Molecular Function	GO:0042802	identical protein binding	CEACAM1	IPI	UniProtKB:P13688	Human	PMID:21982860
Molecular Function	GO:0042802	identical protein binding	CEACAM1	IDA		Human	PMID:26483485
Molecular Function	GO:0042802	identical protein binding	CEACAM1	IPI	UniProtKB:P13688	Human	PMID:26483485
Molecular Function	GO:0042802	identical protein binding	CEACAM1	IPI	UniProtKB:P13688	Human	PMID:27442026
Molecular Function	GO:0042802	identical protein binding	CEACAM6	IPI	UniProtKB:P40199	Human	PMID:21982860
Molecular Function	GO:0042802	identical protein binding	CEACAM6	IDA		Human	PMID:26483485
Molecular Function	GO:0042802	identical protein binding	CEACAM6	IPI	UniProtKB:P40199	Human	PMID:26483485
Molecular Function	GO:0042802	identical protein binding	CEACAM6	IPI	UniProtKB:P40199	Human	PMID:32296183
Molecular Function	GO:0042802	identical protein binding	Ceacam1	IMP	UniProtKB:P16573	Rat	PMID:19948502|RGD:8693360
Molecular Function	GO:0019900	kinase binding	CEACAM1	IPI	UniProtKB:P12931	Human	PMID:7478590
Molecular Function	GO:0005515	protein binding	CEACAM5	IPI	UniProtKB:K0BRG7	Human	PMID:27489282
Molecular Function	GO:0005515	protein binding	PSG1	IPI	UniProtKB:O15294	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PSG1	IPI	UniProtKB:P01137	Human	PMID:25548275
Molecular Function	GO:0005515	protein binding	PSG1	IPI	UniProtKB:P01137:PRO_0000033762	Human	PMID:25548275
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:P49023	Human	PMID:11035932
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:P31997	Human	PMID:11994468
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:Q9NNX6	Human	PMID:16246332
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:Q9NNX6	Human	PMID:16282604
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:P07766	Human	PMID:18424730
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:Q8GH87	Human	PMID:18497748
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:P40199	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:Q16568	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:P26718	Human	PMID:23696226
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:P29350	Human	PMID:23696226
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:Q8TDQ0	Human	PMID:25363763
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:Q04883	Human	PMID:27442026
Molecular Function	GO:0005515	protein binding	CEACAM1	IPI	UniProtKB:Q04884	Human	PMID:27442026
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:P13688	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:P31997	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q16568	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:P31997	Human	PMID:26483485
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:O43711	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:O75593	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:O75603	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:O95231	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:O95872	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:P22105-1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:P33240	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:P36508	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:P78337	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q14119	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q2TAL8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q4VC12	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q63ZY3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q86U10	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q86VI1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q92529	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q96E35	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q96GM5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q96HA1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q99828	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q9BQY4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q9NP98	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q9NZC7-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEACAM6	IPI	UniProtKB:Q9UM19	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Ceacam1	IPI	UniProtKB:P29353	Rat	PMID:11694516|RGD:11041061
Molecular Function	GO:0005515	protein binding	Ceacam1	IPI	UniProtKB:P12785	Rat	PMID:16054098|RGD:11059593
Molecular Function	GO:0005515	protein binding	Ceacam1	IPI	RGD:1307022	Rat	PMID:17623671|RGD:124713560
Molecular Function	GO:0005515	protein binding	Ceacam1	IPI	UniProtKB:P29351	Rat	PMID:19948503|RGD:2325151
Molecular Function	GO:0005515	protein binding	Ceacam1	IPI	UniProtKB:P35235	Rat	PMID:19948503|RGD:2325151
Molecular Function	GO:0046983	protein dimerization activity	Ceacam1	IDA		Rat	PMID:19948503|RGD:2325151
Molecular Function	GO:0046982	protein heterodimerization activity	CEACAM6	IDA		Human	PMID:26483485
Molecular Function	GO:0042803	protein homodimerization activity	CEACAM5	IDA		Human	PMID:18086185
Molecular Function	GO:0042803	protein homodimerization activity	Ceacam1	IDA		Rat	PMID:2373740|RGD:11059597
Molecular Function	GO:0042803	protein homodimerization activity	Ceacam1	IDA		Rat	PMID:8831574|RGD:11059567
Molecular Function	GO:0042803	protein homodimerization activity	Ceacam1	IDA		Rat	PMID:9003371|RGD:11059578
Molecular Function	GO:0019901	protein kinase binding	Ceacam1	IPI	RGD:620795	Rat	PMID:19948503|RGD:2325151
Molecular Function	GO:0019903	protein phosphatase binding	CEACAM1	IPI	UniProtKB:P29350	Human	PMID:18424730
Molecular Function	GO:1990782	protein tyrosine kinase binding	CEACAM1	IPI	UniProtKB:P06239	Human	PMID:18424730
Molecular Function	GO:0044877	protein-containing complex binding	PSG9	IDA		Human	PMID:27389696
Cellular Component	GO:0005912	adherens junction	Ceacam1	IDA		Rat	PMID:19948503|RGD:2325151
Cellular Component	GO:0016324	apical plasma membrane	CEACAM5	IDA		Human	PMID:10436421
Cellular Component	GO:0016324	apical plasma membrane	CEACAM1	IDA		Human	PMID:10436421
Cellular Component	GO:0016324	apical plasma membrane	CEACAM6	IDA		Human	PMID:10436421
Cellular Component	GO:0016324	apical plasma membrane	Ceacam1	IDA		Rat	PMID:7774714|RGD:11059576
Cellular Component	GO:0009925	basal plasma membrane	Ceacam1	IDA		Rat	PMID:7774714|RGD:11059576
Cellular Component	GO:0016323	basolateral plasma membrane	CEACAM5	IDA		Human	PMID:15052268
Cellular Component	GO:0030054	cell junction	CEACAM1	IDA		Human	PMID:8018919
Cellular Component	GO:0030054	cell junction	Ceacam1	IDA		Rat	PMID:19948503|RGD:2325151
Cellular Component	GO:0009986	cell surface	CEACAM5	IDA		Human	PMID:2317824
Cellular Component	GO:0009986	cell surface	CEACAM1	IDA		Human	PMID:25363763
Cellular Component	GO:0009986	cell surface	CEACAM6	IDA		Human	PMID:16204051
Cellular Component	GO:0009986	cell surface	CEACAM6	IDA		Human	PMID:2317824
Cellular Component	GO:0009986	cell surface	CEACAM6	IDA		Human	PMID:8776764
Cellular Component	GO:0009986	cell surface	Ceacam2	IDA		Mouse	PMID:8207827
Cellular Component	GO:0005911	cell-cell junction	CEACAM1	IDA		Human	PMID:16291724
Cellular Component	GO:0005911	cell-cell junction	Ceacam1	IDA		Rat	PMID:17623671|RGD:124713560
Cellular Component	GO:0070062	extracellular exosome	CEACAM5	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CEACAM5	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	CEACAM1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	CEACAM1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	CEACAM6	IDA		Human	PMID:25645918
Cellular Component	GO:0016328	lateral plasma membrane	Ceacam1	IDA		Rat	PMID:7774714|RGD:11059576
Cellular Component	GO:0016020	membrane	CEACAM5	IDA		Human	PMID:2317824
Cellular Component	GO:0016020	membrane	CEACAM1	IDA		Human	PMID:11994468
Cellular Component	GO:0016020	membrane	CEACAM6	IDA		Human	PMID:2317824
Cellular Component	GO:0005886	plasma membrane	CEACAM5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CEACAM5	IDA		Human	PMID:10864933
Cellular Component	GO:0005886	plasma membrane	CEACAM5	IDA		Human	PMID:10931872
Cellular Component	GO:0005886	plasma membrane	CEACAM1	IDA		Human	PMID:17192268
Cellular Component	GO:0005886	plasma membrane	Ceacam1	IDA		Rat	PMID:16054098|RGD:11059593
Cellular Component	GO:0005886	plasma membrane	Ceacam1	IDA		Rat	PMID:17623671|RGD:124713560
Cellular Component	GO:0005886	plasma membrane	Ceacam1	IDA		Rat	PMID:19948503|RGD:2325151
Cellular Component	GO:0005886	plasma membrane	Ceacam1	IDA		Rat	PMID:7518458|RGD:11059589
Cellular Component	GO:0070021	transforming growth factor beta ligand-receptor complex	PSG9	IDA		Human	PMID:27389696
Biological Process	GO:0015721	bile acid and bile salt transport	Ceacam1	IDA		Rat	PMID:7518458|RGD:11059589
Biological Process	GO:0007155	cell adhesion	Ceacam1	IDA		Rat	PMID:8226979|RGD:11059569
Biological Process	GO:0007155	cell adhesion	Ceacam1	IDA		Rat	PMID:8454589|RGD:11059575
Biological Process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	Ceacam1	IDA		Rat	PMID:7774714|RGD:11059576
Biological Process	GO:0032869	cellular response to insulin stimulus	Ceacam1	IDA		Rat	PMID:7626603|RGD:11059572
Biological Process	GO:0097009	energy homeostasis	Ceacam2	IMP	MGI:MGI:5314388	Mouse	PMID:20381490
Biological Process	GO:0097009	energy homeostasis	Ceacam2	IMP	MGI:MGI:5314388	Mouse	PMID:22159884
Biological Process	GO:0002774	Fc receptor mediated inhibitory signaling pathway	PSG9	IDA		Human	PMID:27389696
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	CEACAM5	IMP		Human	PMID:2803308
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	CEACAM6	IMP		Human	PMID:11590190
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	CEACAM6	IMP		Human	PMID:2803308
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	CEACAM6	IMP		Human	PMID:8776764
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	CEACAM5	IMP		Human	PMID:2803308
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	CEACAM6	IMP		Human	PMID:11590190
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	CEACAM6	IMP		Human	PMID:2803308
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	Ceacam1	IDA		Rat	PMID:19948503|RGD:2325151
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	Ceacam1	IDA		Rat	PMID:2373740|RGD:11059597
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	Ceacam1	IDA		Rat	PMID:8536699|RGD:70338
Biological Process	GO:0034109	homotypic cell-cell adhesion	CEACAM5	IDA		Human	PMID:10864933
Biological Process	GO:1901143	insulin catabolic process	Ceacam1	IMP		Rat	PMID:11850617|RGD:734645
Biological Process	GO:0038016	insulin receptor internalization	Ceacam1	IDA		Rat	PMID:7592607|RGD:11059580
Biological Process	GO:0038016	insulin receptor internalization	Ceacam1	IDA		Rat	PMID:9712832|RGD:11059573
Biological Process	GO:2000811	negative regulation of anoikis	CEACAM5	IDA		Human	PMID:10910050
Biological Process	GO:2000811	negative regulation of anoikis	CEACAM6	IMP		Human	PMID:10910050
Biological Process	GO:2000811	negative regulation of anoikis	CEACAM6	IMP		Human	PMID:14724575
Biological Process	GO:0043066	negative regulation of apoptotic process	CEACAM5	IDA		Human	PMID:11448920
Biological Process	GO:0070348	negative regulation of brown fat cell proliferation	Ceacam2	IMP	MGI:MGI:5314388	Mouse	PMID:22159884
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	PSG9	IDA		Human	PMID:27389696
Biological Process	GO:0043318	negative regulation of cytotoxic T cell degranulation	CEACAM1	IDA		Human	PMID:18424730
Biological Process	GO:0045717	negative regulation of fatty acid biosynthetic process	Ceacam1	IMP		Rat	PMID:16054098|RGD:11059593
Biological Process	GO:2000252	negative regulation of feeding behavior	Ceacam2	IMP	MGI:MGI:5314388	Mouse	PMID:20381490
Biological Process	GO:2000346	negative regulation of hepatocyte proliferation	Ceacam1	IMP		Rat	PMID:15467833|RGD:11059592
Biological Process	GO:0010832	negative regulation of myotube differentiation	CEACAM5	IDA		Human	PMID:10931872
Biological Process	GO:0010832	negative regulation of myotube differentiation	CEACAM5	IDA		Human	PMID:8408226
Biological Process	GO:0002859	negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	CEACAM1	IMP		Human	PMID:23696226
Biological Process	GO:0001915	negative regulation of T cell mediated cytotoxicity	CEACAM1	IDA		Human	PMID:18424730
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	CEACAM1	IDA		Human	PMID:18424730
Biological Process	GO:0030335	positive regulation of cell migration	CEACAM6	IMP		Human	PMID:16204051
Biological Process	GO:0030335	positive regulation of cell migration	CEACAM6	IMP		Human	PMID:25171863
Biological Process	GO:0008284	positive regulation of cell population proliferation	CEACAM6	IMP		Human	PMID:25171863
Biological Process	GO:1904906	positive regulation of endothelial cell-matrix adhesion via fibronectin	CEACAM6	IMP		Human	PMID:16204051
Biological Process	GO:0010628	positive regulation of gene expression	PSG9	IDA		Human	PMID:27389696
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	CEACAM6	IMP		Human	PMID:16204051
Biological Process	GO:1903387	positive regulation of homophilic cell adhesion	Ceacam1	IDA		Rat	PMID:8831574|RGD:11059567
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Ceacam1	IDA		Rat	PMID:11994468|RGD:625644
Biological Process	GO:0001558	regulation of cell growth	Ceacam1	IDA		Rat	PMID:11694516|RGD:11041061
Biological Process	GO:0001558	regulation of cell growth	Ceacam1	IDA		Rat	PMID:15467833|RGD:11059592
Biological Process	GO:0030334	regulation of cell migration	CEACAM1	IDA		Human	PMID:16291724
Biological Process	GO:0042058	regulation of epidermal growth factor receptor signaling pathway	Ceacam1	IMP		Rat	PMID:15467833|RGD:11059592
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	Ceacam1	IDA		Rat	PMID:11694516|RGD:11041061
Biological Process	GO:1903385	regulation of homophilic cell adhesion	Ceacam1	IDA		Rat	PMID:8576129|RGD:11059582
Biological Process	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	Ceacam1	IDA		Rat	PMID:11694516|RGD:11041061
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	PSG9	IDA		Human	PMID:27389696
Biological Process	GO:0007165	signal transduction	CEACAM6	IMP		Human	PMID:14724575
Biological Process	GO:0007165	signal transduction	Ceacam1	IDA		Rat	PMID:11994468|RGD:625644
Biological Process	GO:0002461	tolerance induction dependent upon immune response	PSG9	IDA		Human	PMID:27389696
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	PSG9	IDA		Human	PMID:27389696
Biological Process	GO:0036364	transforming growth factor beta1 activation	PSG9	IDA		Human	PMID:27389696
Biological Process	GO:0044319	wound healing, spreading of cells	CEACAM1	IDA		Human	PMID:16291724

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern