Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CELA2A,CELA2B
  • Mouse genes Cela2a
  • Rat genes Cela2a
  • Zfish genes ela2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cela2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	CELA2A	IDA		Human	PMID:31358993
Molecular Function	GO:0005515	protein binding	CELA2A	IPI	UniProtKB:P01009	Human	PMID:31358993
Molecular Function	GO:0005515	protein binding	CELA2B	IPI	UniProtKB:Q13137	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CELA2B	IPI	UniProtKB:Q96MV8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CELA2B	IPI	UniProtKB:Q9BYR8	Human	PMID:32296183
Molecular Function	GO:0017171	serine hydrolase activity	CELA2A	IDA		Human	PMID:20179351
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Cela2a	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0005576	extracellular region	CELA2A	IDA		Human	PMID:31358993
Cellular Component	GO:0036457	keratohyalin granule	CELA2A	IDA		Human	PMID:20179351
Biological Process	GO:1901143	insulin catabolic process	CELA2A	IDA		Human	PMID:31358993
Biological Process	GO:0050796	regulation of insulin secretion	CELA2A	IDA		Human	PMID:31358993
Biological Process	GO:0090330	regulation of platelet aggregation	CELA2A	IDA		Human	PMID:31358993
Biological Process	GO:0032868	response to insulin	CELA2A	IDA		Human	PMID:31358993

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern