Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CENPE
  • Mouse genes Cenpe
  • Rat genes Cenpe
  • Zfish genes cenpe
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cenpe

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043515	kinetochore binding	CENPE	IDA		Human	PMID:9763420
Molecular Function	GO:0043515	kinetochore binding	Cenpe	IDA		Mouse	MGI:MGI:2673075|PMID:12925705
Molecular Function	GO:0008017	microtubule binding	CENPE	IDA		Human	PMID:25908662
Molecular Function	GO:0003777	microtubule motor activity	CENPE	IDA		Human	PMID:25908662
Molecular Function	GO:0003777	microtubule motor activity	CENPE	IMP		Human	PMID:7889940
Molecular Function	GO:0005515	protein binding	CENPE	IPI	UniProtKB:Q9BZD4	Human	PMID:17535814
Molecular Function	GO:0005515	protein binding	CENPE	IPI	UniProtKB:P0DI81	Human	PMID:25918224
Molecular Function	GO:0005515	protein binding	CENPE	IPI	UniProtKB:Q8WVT3	Human	PMID:25918224
Molecular Function	GO:0005515	protein binding	CENPE	IPI	UniProtKB:Q9Y6D9	Human	PMID:26258632
Molecular Function	GO:0005515	protein binding	CENPE	IPI	UniProtKB:P49711	Human	PMID:26321640
Molecular Function	GO:0005515	protein binding	CENPE	IPI	UniProtKB:O60566	Human	PMID:9763420
Molecular Function	GO:0005515	protein binding	CENPE	IPI	UniProtKB:P49454	Human	PMID:9763420
Molecular Function	GO:0019901	protein kinase binding	Cenpe	IPI	UniProtKB:Q9Z1S0	Mouse	MGI:MGI:2673075|PMID:12925705
Cellular Component	GO:0005694	chromosome	CENPE	IDA		Human	PMID:2022189
Cellular Component	GO:0000775	chromosome, centromeric region	CENPE	IDA		Human	PMID:11084331
Cellular Component	GO:0000775	chromosome, centromeric region	CENPE	IDA		Human	PMID:2022189
Cellular Component	GO:0000775	chromosome, centromeric region	CENPE	IDA		Human	PMID:26321640
Cellular Component	GO:0000779	condensed chromosome, centromeric region	CENPE	IDA		Human	PMID:19465021
Cellular Component	GO:0045171	intercellular bridge	CENPE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CENPE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000776	kinetochore	CENPE	IDA		Human	PMID:11682612
Cellular Component	GO:0000776	kinetochore	CENPE	IDA		Human	PMID:12925705
Cellular Component	GO:0000776	kinetochore	CENPE	IDA		Human	PMID:25395579
Cellular Component	GO:0000776	kinetochore	CENPE	IDA		Human	PMID:25918224
Cellular Component	GO:0000776	kinetochore	CENPE	IDA		Human	PMID:9763420
Cellular Component	GO:0000776	kinetochore	Cenpe	IDA		Mouse	MGI:MGI:2673075|PMID:12925705
Cellular Component	GO:0000776	kinetochore	Cenpe	IDA		Mouse	PMID:17938250
Cellular Component	GO:0000776	kinetochore	Cenpe	IDA		Mouse	PMID:18765791
Cellular Component	GO:0005828	kinetochore microtubule	CENPE	IDA		Human	PMID:25908662
Cellular Component	GO:0016020	membrane	CENPE	HDA		Human	PMID:19946888
Cellular Component	GO:0005874	microtubule	CENPE	IDA		Human	PMID:7889940
Cellular Component	GO:0015630	microtubule cytoskeleton	CENPE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030496	midbody	CENPE	IDA		Human	PMID:2022189
Cellular Component	GO:0030496	midbody	CENPE	IDA		Human	PMID:9763420
Cellular Component	GO:0072686	mitotic spindle	CENPE	IDA		Human	GO_REF:0000052
Cellular Component	GO:1990023	mitotic spindle midzone	CENPE	IDA		Human	PMID:2022189
Cellular Component	GO:0005634	nucleus	CENPE	IMP		Human	PMID:9763420
Cellular Component	GO:0000940	outer kinetochore	Cenpe	IDA		Mouse	PMID:19283064
Cellular Component	GO:0051233	spindle midzone	CENPE	IDA		Human	PMID:9763420
Biological Process	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	CENPE	IMP		Human	PMID:15843429
Biological Process	GO:0008608	attachment of spindle microtubules to kinetochore	Cenpe	IMP		Mouse	MGI:MGI:2673075|PMID:12925705
Biological Process	GO:0007059	chromosome segregation	CENPE	IMP		Human	PMID:24748105
Biological Process	GO:0045184	establishment of protein localization	Cenpe	IMP		Mouse	MGI:MGI:2673075|PMID:12925705
Biological Process	GO:0051382	kinetochore assembly	CENPE	IDA		Human	PMID:9763420
Biological Process	GO:0099607	lateral attachment of mitotic spindle microtubules to kinetochore	CENPE	IMP		Human	PMID:23891108
Biological Process	GO:0051310	metaphase plate congression	CENPE	IMP		Human	PMID:23891108
Biological Process	GO:0051310	metaphase plate congression	CENPE	IMP		Human	PMID:25395579
Biological Process	GO:0051310	metaphase plate congression	CENPE	IMP		Human	PMID:25743205
Biological Process	GO:0051310	metaphase plate congression	CENPE	IMP		Human	PMID:25908662
Biological Process	GO:0099606	microtubule plus-end directed mitotic chromosome migration	CENPE	IDA		Human	PMID:25908662
Biological Process	GO:0000278	mitotic cell cycle	CENPE	IMP		Human	PMID:24748105
Biological Process	GO:0007079	mitotic chromosome movement towards spindle pole	CENPE	IDA		Human	PMID:25908662
Biological Process	GO:0007080	mitotic metaphase plate congression	CENPE	IMP		Human	PMID:15843429
Biological Process	GO:0007094	mitotic spindle assembly checkpoint signaling	Cenpe	IMP		Mouse	MGI:MGI:2673075|PMID:12925705
Biological Process	GO:0007052	mitotic spindle organization	CENPE	IMP		Human	PMID:25908662
Biological Process	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	Cenpe	IMP		Mouse	MGI:MGI:2447982|PMID:12361599
Biological Process	GO:0051984	positive regulation of chromosome segregation	Cenpe	IMP		Mouse	MGI:MGI:2673075|PMID:12925705
Biological Process	GO:0045842	positive regulation of mitotic metaphase/anaphase transition	Cenpe	IMP		Mouse	MGI:MGI:2673075|PMID:12925705
Biological Process	GO:0045860	positive regulation of protein kinase activity	CENPE	IMP		Human	PMID:12925705
Biological Process	GO:0045860	positive regulation of protein kinase activity	Cenpe	IDA		Mouse	MGI:MGI:2673075|PMID:12925705
Biological Process	GO:0050793	regulation of developmental process	Cenpe	IMP		Mouse	MGI:MGI:2447982|PMID:12361599
Biological Process	GO:0030071	regulation of mitotic metaphase/anaphase transition	CENPE	IMP		Human	PMID:2022189
Biological Process	GO:0007088	regulation of mitotic nuclear division	Cenpe	IMP		Mouse	MGI:MGI:2447982|PMID:12361599
Biological Process	GO:0031647	regulation of protein stability	Cenpe	IMP		Mouse	PMID:23541922
Biological Process	GO:0007057	spindle assembly involved in female meiosis I	Cenpe	IMP		Mouse	PMID:23541922

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern