Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cep290

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CEP290
- Mouse genes Cep290
- Rat genes Cep290
- Zfish genes cep290
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cep290

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	CEP290	IPI	UniProtKB:O15078	Human	PMID:18723859
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:P18848	Human	PMID:16682973
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:O43303	Human	PMID:18694559
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q15051	Human	PMID:18723859
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q15051	Human	PMID:21565611
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:O43303	Human	PMID:21620453
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:O43303	Human	PMID:22441691
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q9NPJ1	Human	PMID:22446187
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:O95613	Human	PMID:22797915
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q9UPN4	Human	PMID:22797915
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q2M1K9	Human	PMID:22863007
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q15051	Human	PMID:23446637
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q5TB80	Human	PMID:23644468
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q96RK4	Human	PMID:23943788
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:O43303	Human	PMID:24421332
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q9UPN4	Human	PMID:24550735
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q8IYE1	Human	PMID:24816561
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q9UPN4	Human	PMID:24816561
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q9BUW7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q15051	Human	PMID:25552655
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:O43303	Human	PMID:26638075
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q15051	Human	PMID:26638075
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q5TB80	Human	PMID:26638075
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q9UPN4	Human	PMID:26638075
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:A2RUB6	Human	PMID:28235840
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q15051	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q86T90	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q9BUW7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CEP290	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Cep290	IPI	UniProtKB:Q7TSH4\|UniProtKB:Q8BP00	Mouse	MGI:MGI:5013991\|PMID:21565611
Molecular Function	GO:0005515	protein binding	Cep290	IPI	UniProtKB:Q7TSH4	Mouse	MGI:MGI:5784986\|PMID:18694559
Molecular Function	GO:0005515	protein binding	Cep290	IPI	UniProtKB:Q9R0L6	Mouse	MGI:MGI:5013991\|PMID:21565611
Molecular Function	GO:0005515	protein binding	Cep290	IPI	UniProtKB:O08788\|UniProtKB:P28741\|UniProtKB:P48725\|UniProtKB:Q9CU62	Mouse	MGI:MGI:3624140\|PMID:16632484
Molecular Function	GO:0005515	protein binding	Cep290	IPI	UniProtKB:P28741	Mouse	MGI:MGI:3759153\|PMID:17898177
Molecular Function	GO:0005515	protein binding	Cep290	IPI	UniProtKB:Q9R0L6	Mouse	MGI:MGI:3624140\|PMID:16632484
Molecular Function	GO:0005515	protein binding	Cep290	IPI	UniProtKB:Q9R0X5	Mouse	MGI:MGI:3624140\|PMID:16632484
Molecular Function	GO:0005515	protein binding	Cep290	IPI	PR:Q7TSG1	Mouse	PMID:17920017
Cellular Component	GO:0034451	centriolar satellite	CEP290	IDA		Human	PMID:22797915
Cellular Component	GO:0034451	centriolar satellite	CEP290	IDA		Human	PMID:23943788
Cellular Component	GO:0034451	centriolar satellite	Cep290	IDA		Mouse	PMID:24415959
Cellular Component	GO:0034451	centriolar satellite	Cep290	IDA		Mouse	PMID:24469809
Cellular Component	GO:0034451	centriolar satellite	Cep290	IDA		Mouse	PMID:27979967
Cellular Component	GO:0005814	centriole	CEP290	IDA		Human	PMID:27623382
Cellular Component	GO:0005814	centriole	Cep290	IDA		Mouse	PMID:29038301
Cellular Component	GO:0005813	centrosome	CEP290	IDA		Human	PMID:24648492
Cellular Component	GO:0005813	centrosome	CEP290	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005813	centrosome	CEP290	IDA		Human	PMID:14654843
Cellular Component	GO:0005813	centrosome	CEP290	IDA		Human	PMID:16682973
Cellular Component	GO:0005813	centrosome	CEP290	IDA		Human	PMID:21399614
Cellular Component	GO:0005813	centrosome	CEP290	IDA		Human	PMID:24550735
Cellular Component	GO:0005813	centrosome	Cep290	IDA		Mouse	MGI:MGI:5013991\|PMID:21565611
Cellular Component	GO:0005813	centrosome	Cep290	IDA		Mouse	MGI:MGI:3624140\|PMID:16632484
Cellular Component	GO:0005813	centrosome	Cep290	IDA		Mouse	PMID:29487109
Cellular Component	GO:0036064	ciliary basal body	Cep290	IDA		Rat	PMID:17558407\|RGD:11537356
Cellular Component	GO:0036064	ciliary basal body	Cep290	IDA		Rat	PMID:22940612\|RGD:8553427
Cellular Component	GO:0035869	ciliary transition zone	CEP290	IDA		Human	PMID:23943788
Cellular Component	GO:0035869	ciliary transition zone	Cep290	IDA		Mouse	PMID:22446187
Cellular Component	GO:0005737	cytoplasm	CEP290	IDA		Human	PMID:14654843
Cellular Component	GO:0005829	cytosol	CEP290	IDA		Human	PMID:16682973
Cellular Component	GO:0016020	membrane	CEP290	HDA		Human	PMID:19946888
Cellular Component	GO:0036038	MKS complex	Cep290	IDA		Mouse	MGI:MGI:5288576\|PMID:21725307
Cellular Component	GO:0005634	nucleus	CEP290	IDA		Human	PMID:16682973
Cellular Component	GO:0032391	photoreceptor connecting cilium	Cep290	IDA		Mouse	MGI:MGI:3624140\|PMID:16632484
Cellular Component	GO:0032391	photoreceptor connecting cilium	Cep290	IDA		Mouse	MGI:MGI:3653539\|PMID:16682973
Cellular Component	GO:0032391	photoreceptor connecting cilium	Cep290	IDA		Mouse	PMID:23943788
Cellular Component	GO:0120206	photoreceptor distal connecting cilium	Cep290	IDA		Mouse	PMID:29899041
Cellular Component	GO:0001750	photoreceptor outer segment	Cep290	IDA		Mouse	PMID:23943788
Cellular Component	GO:0120205	photoreceptor proximal connecting cilium	Cep290	IDA		Mouse	PMID:29899041
Cellular Component	GO:0032991	protein-containing complex	CEP290	IDA		Human	PMID:24421332
Cellular Component	GO:0120200	rod photoreceptor outer segment	Cep290	IGI	MGI:MGI:2144877	Mouse	PMID:29899041
Biological Process	GO:0043010	camera-type eye development	cep290	IGI	ZFIN:ZDB-MRPHLNO-060209-5,ZFIN:ZDB-MRPHLNO-080428-2	Zfish	PMID:22446187
Biological Process	GO:0021549	cerebellum development	cep290	IMP	ZFIN:ZDB-MRPHLNO-080428-2	Zfish	PMID:16682973
Biological Process	GO:0097711	ciliary basal body-plasma membrane docking	Cep290	IMP	MGI:MGI:5437082	Mouse	PMID:27002738
Biological Process	GO:1905349	ciliary transition zone assembly	Cep290	IMP	MGI:MGI:5437082	Mouse	PMID:27002738
Biological Process	GO:0060271	cilium assembly	CEP290	IDA		Human	PMID:26386044
Biological Process	GO:0060271	cilium assembly	Cep290	IMP		Mouse	MGI:MGI:5013991\|PMID:21565611
Biological Process	GO:0060271	cilium assembly	Cep290	IMP		Mouse	MGI:MGI:5288576\|PMID:21725307
Biological Process	GO:0061371	determination of heart left/right asymmetry	cep290	IMP	ZFIN:ZDB-MRPHLNO-080428-3	Zfish	PMID:34155518
Biological Process	GO:0061371	determination of heart left/right asymmetry	cep290	IMP	ZFIN:ZDB-MRPHLNO-080428-2	Zfish	PMID:34155518
Biological Process	GO:0061371	determination of heart left/right asymmetry	cep290	IMP	ZFIN:ZDB-MRPHLNO-120426-4	Zfish	PMID:34155518
Biological Process	GO:0007368	determination of left/right symmetry	Cep290	IMP		Mouse	PMID:25807483
Biological Process	GO:0006974	DNA damage response	cep290	IMP	ZFIN:ZDB-MRPHLNO-080428-2	Zfish	PMID:26301811
Biological Process	GO:0007163	establishment or maintenance of cell polarity	Cep290	IMP		Mouse	PMID:22832925
Biological Process	GO:0001654	eye development	cep290	IMP	ZFIN:ZDB-MRPHLNO-080428-3	Zfish	PMID:16682973
Biological Process	GO:0001654	eye development	cep290	IMP	ZFIN:ZDB-MRPHLNO-080428-2	Zfish	PMID:16682973
Biological Process	GO:0042462	eye photoreceptor cell development	cep290	IMP		Zfish	PMID:16682973\|ZFIN:ZDB-PUB-060517-14
Biological Process	GO:0042462	eye photoreceptor cell development	cep290	IMP	ZFIN:ZDB-GENO-220926-2	Zfish	PMID:34155518
Biological Process	GO:0042462	eye photoreceptor cell development	cep290	IMP	ZFIN:ZDB-MRPHLNO-120426-4	Zfish	PMID:34155518
Biological Process	GO:0042462	eye photoreceptor cell development	cep290	IMP	ZFIN:ZDB-MRPHLNO-080428-2	Zfish	PMID:21685394
Biological Process	GO:0007369	gastrulation	cep290	IGI	ZFIN:ZDB-MRPHLNO-080716-5,ZFIN:ZDB-MRPHLNO-080716-9	Zfish	PMID:18327255
Biological Process	GO:0060322	head development	cep290	IGI	ZFIN:ZDB-MRPHLNO-120529-5,ZFIN:ZDB-MRPHLNO-150716-1	Zfish	PMID:25937446
Biological Process	GO:0007507	heart development	Cep290	IMP		Mouse	PMID:25807483
Biological Process	GO:0030902	hindbrain development	cep290	IMP		Zfish	PMID:16682973\|ZFIN:ZDB-PUB-060517-14
Biological Process	GO:0048839	inner ear development	cep290	IGI	ZFIN:ZDB-MRPHLNO-060209-5,ZFIN:ZDB-MRPHLNO-080428-2	Zfish	PMID:22446187
Biological Process	GO:0001822	kidney development	Cep290	IMP	MGI:MGI:5437082	Mouse	PMID:27002738
Biological Process	GO:0001822	kidney development	Cep290	IMP	MGI:MGI:5438068	Mouse	PMID:27002738
Biological Process	GO:0000226	microtubule cytoskeleton organization	Cep290	IGI	MGI:MGI:2144877	Mouse	PMID:29899041
Biological Process	GO:1905515	non-motile cilium assembly	Cep290	IMP		Mouse	PMID:22832925
Biological Process	GO:1905515	non-motile cilium assembly	Cep290	IMP		Mouse	PMID:24927541
Biological Process	GO:0030916	otic vesicle formation	cep290	IMP		Zfish	PMID:16682973\|ZFIN:ZDB-PUB-060517-14
Biological Process	GO:0030916	otic vesicle formation	cep290	IMP	ZFIN:ZDB-MRPHLNO-080428-3	Zfish	PMID:16682973
Biological Process	GO:0032475	otolith formation	cep290	IMP	ZFIN:ZDB-MRPHLNO-080428-2	Zfish	PMID:34155518
Biological Process	GO:0032475	otolith formation	cep290	IMP	ZFIN:ZDB-MRPHLNO-080428-3	Zfish	PMID:34155518
Biological Process	GO:0032475	otolith formation	cep290	IMP	ZFIN:ZDB-MRPHLNO-120426-4	Zfish	PMID:34155518
Biological Process	GO:0045494	photoreceptor cell maintenance	Cep290	IGI	MGI:MGI:2143311	Mouse	PMID:23943788
Biological Process	GO:0045494	photoreceptor cell maintenance	Cep290	IMP	MGI:MGI:3624136	Mouse	PMID:23943788
Biological Process	GO:0045494	photoreceptor cell maintenance	cep290	IMP	ZFIN:ZDB-GENO-190920-1	Zfish	PMID:30970040
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CEP290	IDA		Human	PMID:16682973
Biological Process	GO:0090316	positive regulation of intracellular protein transport	CEP290	IMP		Human	PMID:22797915
Biological Process	GO:0048793	pronephros development	cep290	IMP		Zfish	PMID:16682973\|ZFIN:ZDB-PUB-060517-14
Biological Process	GO:0048793	pronephros development	cep290	IMP	ZFIN:ZDB-MRPHLNO-120426-4	Zfish	PMID:34155518
Biological Process	GO:0048793	pronephros development	cep290	IMP	ZFIN:ZDB-MRPHLNO-080428-2	Zfish	PMID:34155518
Biological Process	GO:0048793	pronephros development	cep290	IMP	ZFIN:ZDB-MRPHLNO-080428-3	Zfish	PMID:34155518
Biological Process	GO:0048793	pronephros development	cep290	IGI	ZFIN:ZDB-MRPHLNO-090324-1,ZFIN:ZDB-MRPHLNO-090324-2	Zfish	PMID:18723859
Biological Process	GO:0048793	pronephros development	cep290	IMP	ZFIN:ZDB-MRPHLNO-090324-2	Zfish	PMID:18723859
Biological Process	GO:0015031	protein transport	Cep290	IMP		Mouse	MGI:MGI:3624140\|PMID:16632484
Biological Process	GO:1902017	regulation of cilium assembly	cep290	IMP	ZFIN:ZDB-MRPHLNO-120426-4	Zfish	PMID:34155518
Biological Process	GO:0070201	regulation of establishment of protein localization	CEP290	IMP		Human	PMID:24421332
Biological Process	GO:0046668	regulation of retinal cell programmed cell death	cep290	IMP	ZFiN:ZDB-GENO-230118-4	Zfish	PMID:35692607
Biological Process	GO:0060041	retina development in camera-type eye	Cep290	IMP		Mouse	PMID:21052544
Biological Process	GO:0010842	retina layer formation	cep290	IMP	ZFIN:ZDB-GENO-220926-2	Zfish	PMID:34155518
Biological Process	GO:0010842	retina layer formation	cep290	IMP	ZFIN:ZDB-MRPHLNO-120426-4	Zfish	PMID:34155518
Biological Process	GO:0010842	retina layer formation	cep290	IMP	ZFIN:ZDB-GENO-230118-4	Zfish	PMID:35692607

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.