Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CER1
  • Mouse genes Cer1
  • Rat genes Cer1
  • Zfish genes dand5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cer1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0036122	BMP binding	CER1	IDA		Human	PMID:9660951
Molecular Function	GO:0016015	morphogen activity	CER1	IDA		Human	PMID:9660951
Molecular Function	GO:0005515	protein binding	dand5	IPI	UniProtKB:Q7ZZT5	Zfish	PMID:15084459
Molecular Function	GO:0042803	protein homodimerization activity	Cer1	IDA		Mouse	MGI:MGI:1858315|PMID:10748465
Cellular Component	GO:0005576	extracellular region	Cer1	IDA		Mouse	PMID:9431803
Cellular Component	GO:0005615	extracellular space	Cer1	IDA		Mouse	MGI:MGI:1858315|PMID:10748465
Biological Process	GO:0009948	anterior/posterior axis specification	Cer1	IGI	MGI:MGI:98658	Mouse	PMID:18241853
Biological Process	GO:0009948	anterior/posterior axis specification	Cer1	IGI	MGI:MGI:107405	Mouse	PMID:15004567
Biological Process	GO:0009948	anterior/posterior axis specification	Cer1	IDA		Mouse	PMID:15004567
Biological Process	GO:0009952	anterior/posterior pattern specification	Cer1	IDA		Mouse	PMID:9501024
Biological Process	GO:0030282	bone mineralization	CER1	IMP		Human	PMID:19113921
Biological Process	GO:0042074	cell migration involved in gastrulation	Cer1	IGI	MGI:MGI:107405	Mouse	PMID:15004567
Biological Process	GO:0008283	cell population proliferation	Cer1	IGI	MGI:MGI:107405	Mouse	PMID:15004567
Biological Process	GO:0071276	cellular response to cadmium ion	Cer1	IDA		Mouse	PMID:15219627
Biological Process	GO:0048263	determination of dorsal identity	CER1	IMP		Human	PMID:9660951
Biological Process	GO:0035462	determination of left/right asymmetry in diencephalon	dand5	IMP	ZFIN:ZDB-MRPHLNO-060718-1	Zfish	PMID:15084459
Biological Process	GO:0003140	determination of left/right asymmetry in lateral mesoderm	dand5	IMP	ZFIN:ZDB-MRPHLNO-060718-1	Zfish	PMID:15084459
Biological Process	GO:0003140	determination of left/right asymmetry in lateral mesoderm	dand5	IGI	ZFIN:ZDB-MRPHLNO-060112-1,ZFIN:ZDB-MRPHLNO-060718-1	Zfish	PMID:15084459
Biological Process	GO:0007368	determination of left/right symmetry	dand5	IMP	ZFIN:ZDB-MRPHLNO-060718-1	Zfish	PMID:15084459
Biological Process	GO:0007368	determination of left/right symmetry	dand5	IMP	ZFIN:ZDB-MRPHLNO-060718-1	Zfish	PMID:18985756
Biological Process	GO:0035050	embryonic heart tube development	dand5	IMP	ZFIN:ZDB-MRPHLNO-060718-1	Zfish	PMID:15084459
Biological Process	GO:0001706	endoderm formation	dand5	IMP		Zfish	PMID:15084459
Biological Process	GO:0061966	establishment of left/right asymmetry	dand5	IGI	ZFIN:ZDB-GENO-190830-5	Zfish	PMID:30446628
Biological Process	GO:0061966	establishment of left/right asymmetry	dand5	IMP	ZFIN:ZDB-GENO-190830-3	Zfish	PMID:30446628
Biological Process	GO:0061966	establishment of left/right asymmetry	dand5	IGI	ZFIN:ZDB-GENO-190830-6	Zfish	PMID:30446628
Biological Process	GO:0061966	establishment of left/right asymmetry	dand5	IMP	ZFIN:ZDB-GENO-190830-4	Zfish	PMID:30446628
Biological Process	GO:0007369	gastrulation	Cer1	IGI	MGI:MGI:98658	Mouse	PMID:18241853
Biological Process	GO:0003419	growth plate cartilage chondrocyte proliferation	Cer1	IEP		Mouse	MGI:MGI:5315688|PMID:19113921
Biological Process	GO:0003146	heart jogging	dand5	IMP	ZFIN:ZDB-MRPHLNO-060718-1	Zfish	PMID:15084459
Biological Process	GO:0001947	heart looping	dand5	IMP	ZFIN:ZDB-MRPHLNO-060718-1	Zfish	PMID:15084459
Biological Process	GO:0001707	mesoderm formation	dand5	IMP		Zfish	PMID:15084459
Biological Process	GO:0032926	negative regulation of activin receptor signaling pathway	CER1	IDA		Human	PMID:9660951
Biological Process	GO:0032926	negative regulation of activin receptor signaling pathway	Cer1	IDA		Mouse	MGI:MGI:1858315|PMID:10748465
Biological Process	GO:0032926	negative regulation of activin receptor signaling pathway	dand5	IDA		Zfish	PMID:15084459
Biological Process	GO:0032926	negative regulation of activin receptor signaling pathway	dand5	IMP	ZFIN:ZDB-MRPHLNO-060718-1	Zfish	PMID:15084459
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Cer1	IDA		Mouse	PMID:9501024
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Cer1	IDA		Mouse	PMID:9431803
Biological Process	GO:0008285	negative regulation of cell population proliferation	Cer1	IGI	MGI:MGI:107405	Mouse	PMID:15004567
Biological Process	GO:2000381	negative regulation of mesoderm development	CER1	IMP		Human	PMID:9660951
Biological Process	GO:2000381	negative regulation of mesoderm development	Cer1	IDA		Mouse	MGI:MGI:1858315|PMID:10748465
Biological Process	GO:0007399	nervous system development	CER1	IMP		Human	PMID:9660951
Biological Process	GO:0035582	sequestering of BMP in extracellular matrix	CER1	IDA		Human	PMID:9660951
Biological Process	GO:0035582	sequestering of BMP in extracellular matrix	Cer1	IDA		Mouse	MGI:MGI:1858315|PMID:10748465
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	Cer1	IDA		Mouse	PMID:18462699
Biological Process	GO:0010084	specification of animal organ axis polarity	dand5	IMP	ZFIN:ZDB-MRPHLNO-060718-1	Zfish	PMID:15084459
Biological Process	GO:0001657	ureteric bud development	Cer1	IMP		Mouse	MGI:MGI:5308475|PMID:22114682

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern