Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CERS3
  • Mouse genes Cers3
  • Rat genes Cers3
  • Zfish genes cers3a,cers3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cers3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CERS3	IPI	UniProtKB:Q8N138	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CERS3	IPI	UniProtKB:Q96FB2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CERS3	IPI	UniProtKB:Q99519	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CERS3	IPI	UniProtKB:Q9H0N5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CERS3	IPI	UniProtKB:Q9NUM3	Human	PMID:32296183
Molecular Function	GO:0050291	sphingosine N-acyltransferase activity	CERS3	IDA		Human	PMID:17977534
Molecular Function	GO:0050291	sphingosine N-acyltransferase activity	CERS3	IDA		Human	PMID:22038835
Molecular Function	GO:0050291	sphingosine N-acyltransferase activity	Cers3	IDA		Mouse	MGI:MGI:5303015|PMID:22038835
Molecular Function	GO:0050291	sphingosine N-acyltransferase activity	Cers3	IDA		Mouse	PMID:16753040
Cellular Component	GO:0005783	endoplasmic reticulum	Cers3	IDA		Mouse	MGI:MGI:5303015|PMID:22038835
Biological Process	GO:0046513	ceramide biosynthetic process	CERS3	IDA		Human	PMID:17977534
Biological Process	GO:0046513	ceramide biosynthetic process	CERS3	IDA		Human	PMID:22038835
Biological Process	GO:0046513	ceramide biosynthetic process	CERS3	IMP		Human	PMID:23754960
Biological Process	GO:0046513	ceramide biosynthetic process	Cers3	IDA		Mouse	MGI:MGI:5303015|PMID:22038835
Biological Process	GO:0070268	cornification	Cers3	IMP		Mouse	MGI:MGI:5303015|PMID:22038835
Biological Process	GO:0008544	epidermis development	Cers3	IMP		Mouse	MGI:MGI:5303015|PMID:22038835
Biological Process	GO:0030216	keratinocyte differentiation	CERS3	IMP		Human	PMID:23754960
Biological Process	GO:0030148	sphingolipid biosynthetic process	Cers3	IDA		Mouse	PMID:16753040

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern