Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CES1
  • Mouse genes Ces1c
  • Rat genes Ces1c
  • Zfish genes ces3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ces1c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0106435	carboxylesterase activity	CES1	IDA		Human	PMID:18762277
Molecular Function	GO:0106435	carboxylesterase activity	CES1	IDA		Human	PMID:8218228
Molecular Function	GO:0106435	carboxylesterase activity	Ces1c	IDA		Mouse	PMID:4084216
Molecular Function	GO:0106435	carboxylesterase activity	Ces1c	IDA		Rat	PMID:3360755|RGD:155630594
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds	Ces1c	IDA		Mouse	PMID:2571576
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds	Ces1c	IDA		Mouse	PMID:6838491
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds	Ces1c	IDA		Mouse	PMID:1820020
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds	Ces1c	IDA		Mouse	PMID:1180875
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds	Ces1c	IMP		Mouse	PMID:216346
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds	Ces1c	IDA		Mouse	PMID:216346
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds	Ces1c	IDA		Mouse	PMID:170908
Molecular Function	GO:0042803	protein homodimerization activity	Ces1c	IDA		Rat	PMID:3360755|RGD:155630594
Molecular Function	GO:0004771	sterol esterase activity	CES1	IDA		Human	PMID:11015575
Molecular Function	GO:0004771	sterol esterase activity	CES1	IDA		Human	PMID:16024911
Molecular Function	GO:0004771	sterol esterase activity	CES1	IDA		Human	PMID:16971496
Molecular Function	GO:0004771	sterol esterase activity	CES1	IDA		Human	PMID:18762277
Cellular Component	GO:0005737	cytoplasm	CES1	IDA		Human	PMID:16024911
Cellular Component	GO:0005783	endoplasmic reticulum	CES1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005615	extracellular space	Ces1c	IDA		Mouse	PMID:2571576
Cellular Component	GO:0005615	extracellular space	Ces1c	IDA		Mouse	PMID:4084216
Cellular Component	GO:0005811	lipid droplet	CES1	IDA		Human	PMID:16024911
Cellular Component	GO:0031514	motile cilium	ces3	IDA		Zfish	PMID:25139857
Biological Process	GO:0071397	cellular response to cholesterol	CES1	IMP		Human	PMID:18762277
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	CES1	IMP		Human	PMID:18762277
Biological Process	GO:0006695	cholesterol biosynthetic process	CES1	IDA		Human	PMID:11015575
Biological Process	GO:0042632	cholesterol homeostasis	CES1	IMP		Human	PMID:18762277
Biological Process	GO:0008203	cholesterol metabolic process	CES1	IDA		Human	PMID:16024911
Biological Process	GO:0030855	epithelial cell differentiation	CES1	IDA		Human	PMID:21492153
Biological Process	GO:0051791	medium-chain fatty acid metabolic process	CES1	IDA		Human	PMID:11015575
Biological Process	GO:0010887	negative regulation of cholesterol storage	CES1	IMP		Human	PMID:16971496
Biological Process	GO:0010887	negative regulation of cholesterol storage	CES1	IMP		Human	PMID:18599737
Biological Process	GO:0010887	negative regulation of cholesterol storage	CES1	IMP		Human	PMID:18762277
Biological Process	GO:1901575	organic substance catabolic process	Ces1c	IMP		Mouse	PMID:216346
Biological Process	GO:1901575	organic substance catabolic process	Ces1c	IDA		Mouse	PMID:216346
Biological Process	GO:0010875	positive regulation of cholesterol efflux	CES1	IMP		Human	PMID:16971496
Biological Process	GO:0010875	positive regulation of cholesterol efflux	CES1	IMP		Human	PMID:18599737
Biological Process	GO:0010875	positive regulation of cholesterol efflux	CES1	IMP		Human	PMID:18762277
Biological Process	GO:0090205	positive regulation of cholesterol metabolic process	CES1	IMP		Human	PMID:16971496
Biological Process	GO:0070857	regulation of bile acid biosynthetic process	CES1	IMP		Human	PMID:18599737
Biological Process	GO:0120188	regulation of bile acid secretion	CES1	IMP		Human	PMID:18599737
Biological Process	GO:0009617	response to bacterium	Ces1c	IEP		Mouse	PMID:23012479
Biological Process	GO:0043691	reverse cholesterol transport	CES1	IMP		Human	PMID:18599737
Biological Process	GO:0043691	reverse cholesterol transport	CES1	IMP		Human	PMID:18762277

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern