Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CES1
  • Mouse genes Ces1d
  • Rat genes Ces1d
  • Zfish genes ces3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ces1d

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0106435	carboxylesterase activity	CES1	IDA		Human	PMID:18762277
Molecular Function	GO:0106435	carboxylesterase activity	CES1	IDA		Human	PMID:8218228
Molecular Function	GO:0106435	carboxylesterase activity	Ces1d	IMP	MGI:MGI:4440967	Mouse	PMID:20197051
Molecular Function	GO:0052689	carboxylic ester hydrolase activity	Ces1d	IDA		Mouse	MGI:MGI:5318031|PMID:15220344
Molecular Function	GO:0050253	retinyl-palmitate esterase activity	Ces1d	IDA		Rat	PMID:12230550|RGD:724430
Molecular Function	GO:0004771	sterol esterase activity	CES1	IDA		Human	PMID:11015575
Molecular Function	GO:0004771	sterol esterase activity	CES1	IDA		Human	PMID:16024911
Molecular Function	GO:0004771	sterol esterase activity	CES1	IDA		Human	PMID:16971496
Molecular Function	GO:0004771	sterol esterase activity	CES1	IDA		Human	PMID:18762277
Molecular Function	GO:0004771	sterol esterase activity	Ces1d	IDA		Mouse	MGI:MGI:5318031|PMID:15220344
Molecular Function	GO:0004806	triglyceride lipase activity	Ces1d	IDA		Mouse	MGI:MGI:5318031|PMID:15220344
Cellular Component	GO:0005737	cytoplasm	CES1	IDA		Human	PMID:16024911
Cellular Component	GO:0005829	cytosol	Ces1d	IDA		Mouse	MGI:MGI:5318031|PMID:15220344
Cellular Component	GO:0005829	cytosol	Ces1d	IMP		Mouse	MGI:MGI:6306193|PMID:30862682
Cellular Component	GO:0005829	cytosol	Ces1d	IDA		Mouse	PMID:16804080
Cellular Component	GO:0005783	endoplasmic reticulum	CES1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	Ces1d	IDA		Mouse	PMID:30862682
Cellular Component	GO:0005788	endoplasmic reticulum lumen	Ces1d	IDA		Mouse	MGI:MGI:5318031|PMID:15220344
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Ces1d	IDA		Rat	PMID:12230550|RGD:724430
Cellular Component	GO:0005811	lipid droplet	CES1	IDA		Human	PMID:16024911
Cellular Component	GO:0005811	lipid droplet	Ces1d	IDA		Mouse	MGI:MGI:5318031|PMID:15220344
Cellular Component	GO:0005811	lipid droplet	Ces1d	IDA		Mouse	PMID:30862682
Cellular Component	GO:0005811	lipid droplet	Ces1d	IDA		Mouse	PMID:16804080
Cellular Component	GO:0031514	motile cilium	ces3	IDA		Zfish	PMID:25139857
Biological Process	GO:0046464	acylglycerol catabolic process	Ces1d	IDA		Mouse	MGI:MGI:5318031|PMID:15220344
Biological Process	GO:0071397	cellular response to cholesterol	CES1	IMP		Human	PMID:18762277
Biological Process	GO:0070417	cellular response to cold	Ces1d	IMP		Mouse	PMID:30862682
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	CES1	IMP		Human	PMID:18762277
Biological Process	GO:0006695	cholesterol biosynthetic process	CES1	IDA		Human	PMID:11015575
Biological Process	GO:0042632	cholesterol homeostasis	CES1	IMP		Human	PMID:18762277
Biological Process	GO:0008203	cholesterol metabolic process	CES1	IDA		Human	PMID:16024911
Biological Process	GO:0060086	circadian temperature homeostasis	Ces1d	IMP	MGI:MGI:6501556	Mouse	PMID:30862682
Biological Process	GO:0060086	circadian temperature homeostasis	Ces1d	IMP		Mouse	PMID:30862682
Biological Process	GO:0106106	cold-induced thermogenesis	Ces1d	IMP		Mouse	PMID:30862682
Biological Process	GO:0106106	cold-induced thermogenesis	Ces1d	IMP	MGI:MGI:6501556	Mouse	PMID:30862682
Biological Process	GO:0061725	cytosolic lipolysis	Ces1d	IMP	MGI:MGI:6501556	Mouse	PMID:30862682
Biological Process	GO:0061725	cytosolic lipolysis	Ces1d	IMP		Mouse	PMID:30862682
Biological Process	GO:0030855	epithelial cell differentiation	CES1	IDA		Human	PMID:21492153
Biological Process	GO:0016042	lipid catabolic process	Ces1d	IDA		Mouse	PMID:11470237
Biological Process	GO:0051791	medium-chain fatty acid metabolic process	CES1	IDA		Human	PMID:11015575
Biological Process	GO:0010887	negative regulation of cholesterol storage	CES1	IMP		Human	PMID:16971496
Biological Process	GO:0010887	negative regulation of cholesterol storage	CES1	IMP		Human	PMID:18599737
Biological Process	GO:0010887	negative regulation of cholesterol storage	CES1	IMP		Human	PMID:18762277
Biological Process	GO:0010875	positive regulation of cholesterol efflux	CES1	IMP		Human	PMID:16971496
Biological Process	GO:0010875	positive regulation of cholesterol efflux	CES1	IMP		Human	PMID:18599737
Biological Process	GO:0010875	positive regulation of cholesterol efflux	CES1	IMP		Human	PMID:18762277
Biological Process	GO:0090205	positive regulation of cholesterol metabolic process	CES1	IMP		Human	PMID:16971496
Biological Process	GO:0061411	positive regulation of transcription from RNA polymerase II promoter in response to cold	Ces1d	IMP		Mouse	PMID:30862682
Biological Process	GO:0070857	regulation of bile acid biosynthetic process	CES1	IMP		Human	PMID:18599737
Biological Process	GO:0120188	regulation of bile acid secretion	CES1	IMP		Human	PMID:18599737
Biological Process	GO:0043691	reverse cholesterol transport	CES1	IMP		Human	PMID:18599737
Biological Process	GO:0043691	reverse cholesterol transport	CES1	IMP		Human	PMID:18762277
Biological Process	GO:0019626	short-chain fatty acid catabolic process	Ces1d	IDA		Mouse	PMID:16804080
Biological Process	GO:0034379	very-low-density lipoprotein particle assembly	Ces1d	IMP	MGI:MGI:4440967	Mouse	PMID:20197051

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern