Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CFH
  • Mouse genes Cfh
  • Rat genes Cfh
  • Zfish genes cfh,cfhl1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cfh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001851	complement component C3b binding	Cfh	IPI	UniProtKB:P01024	Mouse	PMID:17028856
Molecular Function	GO:0001851	complement component C3b binding	Cfh	IPI	PR:P01027	Mouse	PMID:16023208
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	CFH	IDA		Human	PMID:22471560
Molecular Function	GO:0008201	heparin binding	CFH	IDA		Human	PMID:22471560
Molecular Function	GO:0008201	heparin binding	Cfh	IDA		Mouse	PMID:17028856
Molecular Function	GO:0008201	heparin binding	Cfh	IDA		Mouse	PMID:16023208
Molecular Function	GO:0042802	identical protein binding	CFH	IPI	UniProtKB:P08603	Human	PMID:19505476
Molecular Function	GO:0042802	identical protein binding	CFH	IPI	UniProtKB:P08603	Human	PMID:19850925
Molecular Function	GO:0042802	identical protein binding	CFH	IPI	UniProtKB:P08603	Human	PMID:26468283
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P01024:PRO_0000005908	Human	PMID:16612335
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P01024:PRO_0000005915	Human	PMID:16612335
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741:PRO_0000023526	Human	PMID:17244159
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:17293598
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P13605	Human	PMID:17293598
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:17339482
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P16946	Human	PMID:18627465
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:18786923
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P26022	Human	PMID:19050261
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:19084272
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:Q9JXV4	Human	PMID:19225461
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P26022	Human	PMID:19632990
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:19680263
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:19850925
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:20042240
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P01024	Human	PMID:21317894
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P01024	Human	PMID:21979047
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02769	Human	PMID:21979047
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P26022:PRO_0000023545	Human	PMID:22786770
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:Q8I2X3	Human	PMID:23332154
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:A0A024A2C9	Human	PMID:24835392
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02649	Human	PMID:26468283
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:A0A024A2C9	Human	PMID:26538390
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:Q932F7	Human	PMID:28258151
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:28533443
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P26022:PRO_0000023545	Human	PMID:28533443
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P01024:PRO_0000005908	Human	PMID:28671664
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:29374201
Molecular Function	GO:0005515	protein binding	Cfh	IPI	UniProtKB:P01027	Mouse	MGI:MGI:5905263|PMID:23487775
Molecular Function	GO:0005515	protein binding	Cfh	IPI	MGI:MGI:96607	Mouse	PMID:28228282
Molecular Function	GO:0005515	protein binding	Cfh	IPI	MGI:MGI:97769	Mouse	PMID:29070671
Cellular Component	GO:0030424	axon	Cfh	IDA		Mouse	PMID:19299737
Cellular Component	GO:0072562	blood microparticle	CFH	HDA		Human	PMID:22516433
Cellular Component	GO:0005737	cytoplasm	Cfh	IDA		Rat	PMID:12617936|RGD:1299271
Cellular Component	GO:0009897	external side of plasma membrane	Cfh	IDA		Mouse	PMID:19299737
Cellular Component	GO:0070062	extracellular exosome	CFH	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	Cfh	IDA		Mouse	PMID:20675597
Cellular Component	GO:0005576	extracellular region	Cfh	IDA		Mouse	PMID:19411110
Cellular Component	GO:0005615	extracellular space	Cfh	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Cfh	IDA		Mouse	PMID:17028856
Cellular Component	GO:0005615	extracellular space	Cfh	IDA		Rat	PMID:12911541|RGD:1599888
Cellular Component	GO:0043025	neuronal cell body	Cfh	IDA		Mouse	PMID:19299737
Cellular Component	GO:0005634	nucleus	Cfh	IDA		Rat	PMID:12617936|RGD:1299271
Cellular Component	GO:0005886	plasma membrane	Cfh	IDA		Rat	PMID:12911541|RGD:1599888
Cellular Component	GO:1905370	serine-type endopeptidase complex	CFH	IPI		Human	PMID:28671664
Cellular Component	GO:0106139	symbiont cell surface	CFH	IDA		Human	PMID:23332154
Biological Process	GO:0001905	activation of membrane attack complex	Cfh	IMP		Mouse	PMID:20813971
Biological Process	GO:0001525	angiogenesis	Cfh	IMP		Mouse	PMID:28057640
Biological Process	GO:0046034	ATP metabolic process	Cfh	IMP		Mouse	PMID:26149919
Biological Process	GO:0060348	bone development	Cfh	IGI		Mouse	PMID:19828624
Biological Process	GO:0051216	cartilage development	Cfh	IGI		Mouse	PMID:19828624
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Cfh	IEP		Rat	PMID:20484586|RGD:7364950
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cfh	IGI		Mouse	PMID:19828624
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cfh	IEP		Rat	PMID:12121434|RGD:632369
Biological Process	GO:0071346	cellular response to type II interferon	Cfh	IEP		Rat	PMID:12121434|RGD:632369
Biological Process	GO:0006956	complement activation	CFH	IDA		Human	PMID:24835392
Biological Process	GO:0006956	complement activation	Cfh	IMP		Mouse	PMID:28057640
Biological Process	GO:0006956	complement activation	Cfh	IGI		Mouse	PMID:20702729
Biological Process	GO:0006956	complement activation	Cfh	IDA		Mouse	PMID:20675597
Biological Process	GO:0006956	complement activation	Cfh	IMP		Mouse	PMID:19541934
Biological Process	GO:0006956	complement activation	Cfh	IDA		Mouse	PMID:19411110
Biological Process	GO:0006956	complement activation	Cfh	IMP		Mouse	PMID:17921253
Biological Process	GO:0006956	complement activation	Cfh	IMP		Mouse	PMID:17517971
Biological Process	GO:0006956	complement activation	Cfh	IMP		Mouse	PMID:15574507
Biological Process	GO:0006956	complement activation	Cfh	IEP		Rat	PMID:12911541|RGD:1599888
Biological Process	GO:0006957	complement activation, alternative pathway	Cfh	IMP		Mouse	PMID:27564415
Biological Process	GO:0006957	complement activation, alternative pathway	Cfh	IGI		Mouse	PMID:27564415
Biological Process	GO:0006957	complement activation, alternative pathway	Cfh	IGI		Mouse	PMID:19828624
Biological Process	GO:0008340	determination of adult lifespan	Cfh	IMP		Mouse	PMID:28057640
Biological Process	GO:0010467	gene expression	Cfh	IMP		Mouse	PMID:24929970
Biological Process	GO:0010467	gene expression	Cfh	IMP		Mouse	PMID:23844226
Biological Process	GO:0010467	gene expression	Cfh	IMP		Mouse	PMID:15574507
Biological Process	GO:0032835	glomerulus development	Cfh	IGI		Mouse	PMID:20702729
Biological Process	GO:0032835	glomerulus development	Cfh	IMP		Mouse	PMID:17517971
Biological Process	GO:0032835	glomerulus development	Cfh	IGI		Mouse	PMID:16769899
Biological Process	GO:0032835	glomerulus development	Cfh	IMP		Mouse	PMID:15574507
Biological Process	GO:0002434	immune complex clearance	Cfh	IGI		Mouse	PMID:20702729
Biological Process	GO:0006955	immune response	Cfh	IMP		Mouse	PMID:19541934
Biological Process	GO:0016064	immunoglobulin mediated immune response	Cfh	IGI		Mouse	PMID:19828624
Biological Process	GO:0006954	inflammatory response	Cfh	IMP		Mouse	PMID:28228282
Biological Process	GO:0006954	inflammatory response	Cfh	IMP		Mouse	PMID:26149919
Biological Process	GO:0006954	inflammatory response	Cfh	IGI		Mouse	PMID:19828624
Biological Process	GO:0090594	inflammatory response to wounding	Cfh	IGI		Mouse	PMID:21148255
Biological Process	GO:0001822	kidney development	Cfh	IMP		Mouse	PMID:17517971
Biological Process	GO:0001822	kidney development	Cfh	IGI		Mouse	PMID:16769899
Biological Process	GO:0032042	mitochondrial DNA metabolic process	Cfh	IMP		Mouse	PMID:30705315
Biological Process	GO:0140053	mitochondrial gene expression	Cfh	IMP		Mouse	PMID:26149919
Biological Process	GO:0007005	mitochondrion organization	Cfh	IMP		Mouse	PMID:30705315
Biological Process	GO:0070487	monocyte aggregation	Cfh	IMP		Mouse	PMID:28228282
Biological Process	GO:0050905	neuromuscular process	Cfh	IMP		Mouse	PMID:29070671
Biological Process	GO:0001780	neutrophil homeostasis	Cfh	IGI		Mouse	PMID:16769899
Biological Process	GO:0002251	organ or tissue specific immune response	Cfh	IGI		Mouse	PMID:20702729
Biological Process	GO:0051640	organelle localization	Cfh	IMP		Mouse	PMID:17921253
Biological Process	GO:0046530	photoreceptor cell differentiation	Cfh	IMP		Mouse	PMID:30705315
Biological Process	GO:0046530	photoreceptor cell differentiation	Cfh	IMP		Mouse	PMID:26149919
Biological Process	GO:0070527	platelet aggregation	Cfh	IMP		Mouse	PMID:28057640
Biological Process	GO:0006508	proteolysis	CFH	IDA		Human	PMID:28671664
Biological Process	GO:0030449	regulation of complement activation	CFH	IDA		Human	PMID:25284781
Biological Process	GO:0030449	regulation of complement activation	Cfh	IMP	MGI:MGI:2384179	Mouse	PMID:18947875
Biological Process	GO:0030449	regulation of complement activation	Cfh	IDA		Rat	PMID:12374811|RGD:628500
Biological Process	GO:0030451	regulation of complement activation, alternative pathway	CFH	IDA		Human	PMID:20378178
Biological Process	GO:0030451	regulation of complement activation, alternative pathway	CFH	IDA		Human	PMID:28671664
Biological Process	GO:1903659	regulation of complement-dependent cytotoxicity	CFH	IDA		Human	PMID:25284781
Biological Process	GO:0034097	response to cytokine	Cfh	IDA		Mouse	PMID:19299737
Biological Process	GO:0002021	response to dietary excess	Cfh	IMP		Mouse	PMID:25991857
Biological Process	GO:0060041	retina development in camera-type eye	Cfh	IMP		Mouse	PMID:30705315
Biological Process	GO:0060041	retina development in camera-type eye	Cfh	IMP		Mouse	PMID:28057640
Biological Process	GO:0060041	retina development in camera-type eye	Cfh	IGI		Mouse	PMID:28057640
Biological Process	GO:0060041	retina development in camera-type eye	Cfh	IMP		Mouse	PMID:17921253
Biological Process	GO:0003406	retinal pigment epithelium development	Cfh	IMP		Mouse	PMID:25991857
Biological Process	GO:0003406	retinal pigment epithelium development	Cfh	IMP		Mouse	PMID:23844226
Biological Process	GO:0046548	retinal rod cell development	Cfh	IMP		Mouse	PMID:17921253
Biological Process	GO:0035886	vascular associated smooth muscle cell differentiation	Cfh	IMP		Mouse	PMID:28057640
Biological Process	GO:0035886	vascular associated smooth muscle cell differentiation	Cfh	IGI		Mouse	PMID:28057640
Biological Process	GO:0007601	visual perception	Cfh	IMP		Mouse	PMID:25991857
Biological Process	GO:0007601	visual perception	Cfh	IMP		Mouse	PMID:17921253
Biological Process	GO:0007601	visual perception	Cfh	IMP		Mouse	PMID:17517971

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern