Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CFH
  • Mouse genes Cfhr4
  • Rat genes Cfh
  • Zfish genes cfh,cfhl1,cfhl2,cfhl3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cfhr4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001851	complement component C3b binding	Cfhr4	IPI	UniProtKB:P01024	Mouse	PMID:17028856
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	CFH	IDA		Human	PMID:22471560
Molecular Function	GO:0008201	heparin binding	CFH	IDA		Human	PMID:22471560
Molecular Function	GO:0008201	heparin binding	Cfhr4	IDA		Mouse	PMID:17028856
Molecular Function	GO:0042802	identical protein binding	CFH	IPI	UniProtKB:P08603	Human	PMID:19505476
Molecular Function	GO:0042802	identical protein binding	CFH	IPI	UniProtKB:P08603	Human	PMID:19850925
Molecular Function	GO:0042802	identical protein binding	CFH	IPI	UniProtKB:P08603	Human	PMID:26468283
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P01024:PRO_0000005908	Human	PMID:16612335
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P01024:PRO_0000005915	Human	PMID:16612335
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741:PRO_0000023526	Human	PMID:17244159
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:17293598
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P13605	Human	PMID:17293598
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:17339482
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P16946	Human	PMID:18627465
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:18786923
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P26022	Human	PMID:19050261
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:19084272
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:Q9JXV4	Human	PMID:19225461
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P26022	Human	PMID:19632990
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:19680263
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:19850925
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:20042240
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P01024	Human	PMID:21317894
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P01024	Human	PMID:21979047
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02769	Human	PMID:21979047
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P26022:PRO_0000023545	Human	PMID:22786770
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:Q8I2X3	Human	PMID:23332154
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:A0A024A2C9	Human	PMID:24835392
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02649	Human	PMID:26468283
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:A0A024A2C9	Human	PMID:26538390
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:Q932F7	Human	PMID:28258151
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:28533443
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P26022:PRO_0000023545	Human	PMID:28533443
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P01024:PRO_0000005908	Human	PMID:28671664
Molecular Function	GO:0005515	protein binding	CFH	IPI	UniProtKB:P02741	Human	PMID:29374201
Cellular Component	GO:0072562	blood microparticle	CFH	HDA		Human	PMID:22516433
Cellular Component	GO:0005737	cytoplasm	Cfh	IDA		Rat	PMID:12617936|RGD:1299271
Cellular Component	GO:0070062	extracellular exosome	CFH	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	Cfhr4	IDA		Mouse	PMID:17028856
Cellular Component	GO:0005615	extracellular space	Cfh	IDA		Rat	PMID:12911541|RGD:1599888
Cellular Component	GO:0005634	nucleus	Cfh	IDA		Rat	PMID:12617936|RGD:1299271
Cellular Component	GO:0005886	plasma membrane	Cfh	IDA		Rat	PMID:12911541|RGD:1599888
Cellular Component	GO:1905370	serine-type endopeptidase complex	CFH	IPI		Human	PMID:28671664
Cellular Component	GO:0106139	symbiont cell surface	CFH	IDA		Human	PMID:23332154
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Cfh	IEP		Rat	PMID:20484586|RGD:7364950
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cfh	IEP		Rat	PMID:12121434|RGD:632369
Biological Process	GO:0071346	cellular response to type II interferon	Cfh	IEP		Rat	PMID:12121434|RGD:632369
Biological Process	GO:0006956	complement activation	CFH	IDA		Human	PMID:24835392
Biological Process	GO:0006956	complement activation	Cfh	IEP		Rat	PMID:12911541|RGD:1599888
Biological Process	GO:0006508	proteolysis	CFH	IDA		Human	PMID:28671664
Biological Process	GO:0030449	regulation of complement activation	CFH	IDA		Human	PMID:25284781
Biological Process	GO:0030449	regulation of complement activation	Cfh	IDA		Rat	PMID:12374811|RGD:628500
Biological Process	GO:0030451	regulation of complement activation, alternative pathway	CFH	IDA		Human	PMID:20378178
Biological Process	GO:0030451	regulation of complement activation, alternative pathway	CFH	IDA		Human	PMID:28671664
Biological Process	GO:1903659	regulation of complement-dependent cytotoxicity	CFH	IDA		Human	PMID:25284781

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern