Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CFL1
  • Mouse genes Cfl1
  • Rat genes Cfl1
  • Zfish genes cfl1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cfl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Cfl1	IMP		Rat	PMID:12566455|RGD:724709
Molecular Function	GO:0051015	actin filament binding	CFL1	IDA		Human	PMID:11812157
Molecular Function	GO:0051015	actin filament binding	Cfl1	IDA		Mouse	MGI:MGI:5784994|PMID:11809832
Molecular Function	GO:0051015	actin filament binding	Cfl1	IDA		Rat	PMID:24740405|RGD:11570417
Molecular Function	GO:1902936	phosphatidylinositol bisphosphate binding	Cfl1	IPI	CHEBI:18348	Rat	PMID:19029335|RGD:11041716
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P63104	Human	PMID:12361576
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P27958:PRO_0000037566	Human	PMID:15846844
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P60709	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P63261	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P54253	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:O14939	Human	PMID:17853892
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P53667	Human	PMID:17853892
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:Q13393	Human	PMID:17853892
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P53667	Human	PMID:19424295
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P00533	Human	PMID:20029029
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P53667	Human	PMID:20133759
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P57058	Human	PMID:20133759
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:Q8WYL5	Human	PMID:21525957
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P60709	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P63261	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:Q1KLZ0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:Q549N0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P0DOE7	Human	PMID:25556234
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P60709	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P60709	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P60709	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P63261	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CFL1	IPI	UniProtKB:Q96CV9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Cfl1	IPI	UniProtKB:Q9R1M5|UniProtKB:Q9WVB3	Mouse	MGI:MGI:6296386|PMID:25208553
Molecular Function	GO:0005515	protein binding	Cfl1	IPI	UniProtKB:Q66HL2	Rat	PMID:19704022|RGD:8553677
Molecular Function	GO:0005515	protein binding	Cfl1	IPI	UniProtKB:P54686	Rat	PMID:20668166|RGD:8553986
Molecular Function	GO:0005515	protein binding	Cfl1	IPI	RGD:1311323	Rat	PMID:23765104|RGD:11570554
Molecular Function	GO:0005515	protein binding	Cfl1	IPI	RGD:2192	Rat	PMID:24195677|RGD:10053669
Molecular Function	GO:0019903	protein phosphatase binding	Cfl1	IPI	RGD:1351799	Rat	PMID:26324884|RGD:11568705
Molecular Function	GO:0005102	signaling receptor binding	Cfl1	IPI	UniProtKB:P97484	Mouse	MGI:MGI:5511064|PMID:24052308
Cellular Component	GO:0031252	cell leading edge	Cfl1	IDA		Rat	PMID:15252126|RGD:2306210
Cellular Component	GO:0005911	cell-cell junction	Cfl1	IDA		Mouse	PMID:23793062
Cellular Component	GO:0090732	cofilin-actin rod	Cfl1	IDA		Rat	PMID:24760020|RGD:11570414
Cellular Component	GO:0030864	cortical actin cytoskeleton	Cfl1	IDA		Mouse	PMID:15004221
Cellular Component	GO:0030864	cortical actin cytoskeleton	Cfl1	IDA		Mouse	PMID:15548599
Cellular Component	GO:0005737	cytoplasm	CFL1	IDA		Human	PMID:25556234
Cellular Component	GO:0005737	cytoplasm	Cfl1	IDA		Mouse	PMID:15548599
Cellular Component	GO:0005737	cytoplasm	Cfl1	IDA		Rat	PMID:15252126|RGD:2306210
Cellular Component	GO:0043197	dendritic spine	Cfl1	IDA		Rat	PMID:24760020|RGD:11570414
Cellular Component	GO:0070062	extracellular exosome	CFL1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	CFL1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	CFL1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	CFL1	HDA		Human	PMID:23580065
Cellular Component	GO:0030175	filopodium	Cfl1	IDA		Rat	PMID:24515839|RGD:11570532
Cellular Component	GO:0005925	focal adhesion	CFL1	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	CFL1	IDA		Human	PMID:29162887
Cellular Component	GO:0098978	glutamatergic synapse	Cfl1	EXP		Rat	PMID:16025109|RGD:13702428
Cellular Component	GO:0098978	glutamatergic synapse	Cfl1	IDA		Rat	PMID:16025109|RGD:13702428
Cellular Component	GO:0030426	growth cone	Cfl1	IDA		Rat	PMID:24515839|RGD:11570532
Cellular Component	GO:0030027	lamellipodium	Cfl1	IDA		Mouse	MGI:MGI:5908532|PMID:25107909
Cellular Component	GO:0030027	lamellipodium	Cfl1	IDA		Rat	PMID:15252126|RGD:2306210
Cellular Component	GO:0016020	membrane	CFL1	HDA		Human	PMID:19946888
Cellular Component	GO:0031966	mitochondrial membrane	Cfl1	IDA		Rat	PMID:27642592|RGD:11568691
Cellular Component	GO:0043005	neuron projection	Cfl1	IDA		Rat	PMID:24760020|RGD:11570414
Cellular Component	GO:0043025	neuronal cell body	Cfl1	IDA		Rat	PMID:24515839|RGD:11570532
Cellular Component	GO:0097060	synaptic membrane	Cfl1	IDA		Rat	PMID:25708984|RGD:12738361
Cellular Component	GO:0031982	vesicle	CFL1	HDA		Human	PMID:19190083
Biological Process	GO:0030042	actin filament depolymerization	CFL1	IDA		Human	PMID:11812157
Biological Process	GO:0030042	actin filament depolymerization	Cfl1	IDA		Mouse	MGI:MGI:5784994|PMID:11809832
Biological Process	GO:0030043	actin filament fragmentation	Cfl1	IDA		Mouse	MGI:MGI:5784994|PMID:11809832
Biological Process	GO:0007015	actin filament organization	Cfl1	IMP		Mouse	MGI:MGI:6296386|PMID:25208553
Biological Process	GO:0007015	actin filament organization	Cfl1	IMP	MGI:MGI:3574399	Mouse	PMID:15649475
Biological Process	GO:0007015	actin filament organization	cfl1	IMP	ZFIN:ZDB-MRPHLNO-110118-4	Zfish	PMID:21203473
Biological Process	GO:0030030	cell projection organization	Cfl1	IDA		Rat	PMID:16286931|RGD:8554187
Biological Process	GO:0030030	cell projection organization	cfl1	IMP	ZFIN:ZDB-MRPHLNO-110118-4	Zfish	PMID:21203473
Biological Process	GO:0070586	cell-cell adhesion involved in gastrulation	cfl1	IMP	ZFIN:ZDB-MRPHLNO-110118-4	Zfish	PMID:21203473
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Cfl1	IMP		Rat	PMID:23704350|RGD:11570555
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Cfl1	IEP		Rat	PMID:26324884|RGD:11568705
Biological Process	GO:0071362	cellular response to ether	Cfl1	IEP		Rat	PMID:24239914|RGD:11570536
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Cfl1	IDA		Rat	PMID:23765104|RGD:11570554
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	Cfl1	IDA		Rat	PMID:24195677|RGD:10053669
Biological Process	GO:0071347	cellular response to interleukin-1	Cfl1	IDA		Rat	PMID:24760020|RGD:11570414
Biological Process	GO:0071354	cellular response to interleukin-6	Cfl1	IDA		Rat	PMID:24760020|RGD:11570414
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Cfl1	IDA		Rat	PMID:24760020|RGD:11570414
Biological Process	GO:0060271	cilium assembly	cfl1	IGI	ZFIN:ZDB-GENE-040426-899	Zfish	PMID:26704451
Biological Process	GO:0007010	cytoskeleton organization	CFL1	IMP		Human	PMID:21834987
Biological Process	GO:0061371	determination of heart left/right asymmetry	cfl1	IGI	ZFIN:ZDB-GENE-040426-899	Zfish	PMID:26704451
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	cfl1	IMP	ZFIN:ZDB-MRPHLNO-110118-4	Zfish	PMID:21203473
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	cfl1	IMP	ZFIN:ZDB-MRPHLNO-110118-5	Zfish	PMID:21203473
Biological Process	GO:0030010	establishment of cell polarity	Cfl1	IMP	MGI:MGI:3574399	Mouse	PMID:15649475
Biological Process	GO:0051293	establishment of spindle localization	Cfl1	IMP		Mouse	MGI:MGI:6296386|PMID:25208553
Biological Process	GO:0021766	hippocampus development	Cfl1	IEP		Rat	PMID:27073215|RGD:11568695
Biological Process	GO:0000281	mitotic cytokinesis	Cfl1	IMP		Mouse	PMID:15548599
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	Cfl1	EXP		Rat	PMID:16025109|RGD:13702428
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	Cfl1	IDA		Rat	PMID:16025109|RGD:13702428
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Cfl1	EXP		Rat	PMID:16025109|RGD:13702428
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Cfl1	IDA		Rat	PMID:16025109|RGD:13702428
Biological Process	GO:0032232	negative regulation of actin filament bundle assembly	Cfl1	IMP		Rat	PMID:24093776|RGD:11570550
Biological Process	GO:0030835	negative regulation of actin filament depolymerization	Cfl1	IMP		Rat	PMID:15252126|RGD:2306210
Biological Process	GO:0007162	negative regulation of cell adhesion	Cfl1	IMP		Rat	PMID:26169356|RGD:11074527
Biological Process	GO:2000146	negative regulation of cell motility	Cfl1	IMP		Rat	PMID:24093776|RGD:11570550
Biological Process	GO:0045792	negative regulation of cell size	Cfl1	IDA		Rat	PMID:16286931|RGD:8554187
Biological Process	GO:1902951	negative regulation of dendritic spine maintenance	Cfl1	IMP		Rat	PMID:23974706|RGD:11570553
Biological Process	GO:0010593	negative regulation of lamellipodium assembly	Cfl1	IMP		Rat	PMID:24093776|RGD:11570550
Biological Process	GO:1905875	negative regulation of postsynaptic density organization	Cfl1	IMP		Rat	PMID:26169356|RGD:11074527
Biological Process	GO:0051511	negative regulation of unidimensional cell growth	Cfl1	IMP		Rat	PMID:24093776|RGD:11570550
Biological Process	GO:0001755	neural crest cell migration	Cfl1	IMP	MGI:MGI:3574399	Mouse	PMID:15649475
Biological Process	GO:0001842	neural fold formation	Cfl1	IMP	MGI:MGI:3574399	Mouse	PMID:15649475
Biological Process	GO:0044794	positive regulation by host of viral process	CFL1	IMP		Human	PMID:25556234
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	Cfl1	IDA		Mouse	MGI:MGI:5554982|PMID:23921380
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	Cfl1	IMP		Mouse	PMID:15548599
Biological Process	GO:2000814	positive regulation of barbed-end actin filament capping	Cfl1	IMP		Rat	PMID:23704350|RGD:11570555
Biological Process	GO:0030307	positive regulation of cell growth	Cfl1	IMP		Rat	PMID:24093776|RGD:11570550
Biological Process	GO:2000147	positive regulation of cell motility	Cfl1	IMP		Rat	PMID:24214978|RGD:9590192
Biological Process	GO:0060999	positive regulation of dendritic spine development	Cfl1	IMP		Rat	PMID:25723479|RGD:11570400
Biological Process	GO:0040019	positive regulation of embryonic development	Cfl1	IMP		Mouse	MGI:MGI:6296386|PMID:25208553
Biological Process	GO:2000784	positive regulation of establishment of cell polarity regulating cell shape	Cfl1	IMP		Rat	PMID:26169356|RGD:11074527
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	Cfl1	IMP		Rat	PMID:24093776|RGD:11570550
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	Cfl1	IMP		Rat	PMID:15252126|RGD:2306210
Biological Process	GO:1904783	positive regulation of NMDA glutamate receptor activity	Cfl1	IMP		Rat	PMID:24089484|RGD:11570552
Biological Process	GO:1905873	positive regulation of protein localization to cell leading edge	Cfl1	IMP		Rat	PMID:26324884|RGD:11568705
Biological Process	GO:0045862	positive regulation of proteolysis	Cfl1	IMP		Rat	PMID:24093776|RGD:11570550
Biological Process	GO:0031915	positive regulation of synaptic plasticity	Cfl1	IMP		Rat	PMID:25723479|RGD:11570400
Biological Process	GO:0006606	protein import into nucleus	Cfl1	IMP		Rat	PMID:12566455|RGD:724709
Biological Process	GO:0006468	protein phosphorylation	Cfl1	IDA		Mouse	PMID:17018287
Biological Process	GO:0022604	regulation of cell morphogenesis	CFL1	IMP		Human	PMID:21834987
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	CFL1	IMP		Human	PMID:24464040
Biological Process	GO:0014823	response to activity	Cfl1	IEP		Rat	PMID:26678157|RGD:11568698
Biological Process	GO:0043200	response to amino acid	Cfl1	IDA		Mouse	PMID:17018287
Biological Process	GO:0014070	response to organic cyclic compound	Cfl1	IEP		Rat	PMID:26678157|RGD:11568698
Biological Process	GO:0009615	response to virus	CFL1	IEP		Human	PMID:16548883

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern