Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CFLAR
  • Mouse genes Cflar
  • Rat genes Cflar
  • Zfish genes cflara
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cflar

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005123	death receptor binding	Cflar	IPI	RGD:619831	Rat	PMID:17518537|RGD:2290177
Molecular Function	GO:0008047	enzyme activator activity	CFLAR	IDA		Human	PMID:9208847
Molecular Function	GO:0016504	peptidase activator activity	Cflar	IDA		Mouse	PMID:21368763
Molecular Function	GO:0002020	protease binding	CFLAR	IPI	UniProtKB:P42574	Human	PMID:9208847
Molecular Function	GO:0002020	protease binding	CFLAR	IPI	UniProtKB:Q14790	Human	PMID:9208847
Molecular Function	GO:0002020	protease binding	Cflar	IPI	RGD:620945	Rat	PMID:17518537|RGD:2290177
Molecular Function	GO:0005515	protein binding	CFLAR	IPI	UniProtKB:Q8WXF8	Human	PMID:11741985
Molecular Function	GO:0005515	protein binding	CFLAR	IPI	UniProtKB:Q14790	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	CFLAR	IPI	UniProtKB:Q92851	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	CFLAR	IPI	UniProtKB:Q14790	Human	PMID:17047155
Molecular Function	GO:0005515	protein binding	CFLAR	IPI	UniProtKB:Q92851	Human	PMID:23541952
Molecular Function	GO:0005515	protein binding	CFLAR	IPI	UniProtKB:Q14790	Human	PMID:24438025
Molecular Function	GO:0005515	protein binding	CFLAR	IPI	UniProtKB:Q92851	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CFLAR	IPI	UniProtKB:Q13077	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CFLAR	IPI	UniProtKB:Q13077	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CFLAR	IPI	UniProtKB:Q13077	Human	PMID:9208847
Molecular Function	GO:0005515	protein binding	CFLAR	IPI	UniProtKB:Q13158	Human	PMID:9208847
Molecular Function	GO:0005515	protein binding	Cflar	IPI	UniProtKB:Q60855	Mouse	MGI:MGI:6362574|PMID:31519887
Molecular Function	GO:0005515	protein binding	Cflar	IPI	PR:O89110	Mouse	PMID:21368763
Molecular Function	GO:0044877	protein-containing complex binding	Cflar	IPI	RGD:620945|RGD:619831	Rat	PMID:17518537|RGD:2290177
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	Cflar	IDA		Rat	PMID:16493077|RGD:4143200
Cellular Component	GO:0005737	cytoplasm	CFLAR	IDA		Human	PMID:18073330
Cellular Component	GO:0005737	cytoplasm	Cflar	IDA		Mouse	PMID:16263940
Cellular Component	GO:0031264	death-inducing signaling complex	CFLAR	IDA		Human	PMID:21803845
Cellular Component	GO:0031264	death-inducing signaling complex	Cflar	IDA		Rat	PMID:17518537|RGD:2290177
Cellular Component	GO:0045121	membrane raft	Cflar	IDA		Rat	PMID:17518537|RGD:2290177
Cellular Component	GO:0097342	ripoptosome	CFLAR	IDA		Human	PMID:21737330
Biological Process	GO:0006915	apoptotic process	CFLAR	IMP		Human	PMID:21737330
Biological Process	GO:0006915	apoptotic process	Cflar	IMP		Mouse	PMID:16263940
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Cflar	IEP		Rat	PMID:16167066|RGD:11341697
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Cflar	IEP		Rat	PMID:16033771|RGD:11341689
Biological Process	GO:0071392	cellular response to estradiol stimulus	Cflar	IEP		Rat	PMID:26566102|RGD:11341731
Biological Process	GO:0071456	cellular response to hypoxia	Cflar	IEP		Rat	PMID:12031707|RGD:8663470
Biological Process	GO:0032869	cellular response to insulin stimulus	Cflar	IEP		Rat	PMID:18292530|RGD:11341712
Biological Process	GO:0071732	cellular response to nitric oxide	Cflar	IMP		Rat	PMID:18292530|RGD:11341712
Biological Process	GO:0070266	necroptotic process	Cflar	IGI	MGI:MGI:2154952	Mouse	PMID:21368763
Biological Process	GO:0070266	necroptotic process	Cflar	IGI	MGI:MGI:1261423	Mouse	PMID:21368763
Biological Process	GO:0070266	necroptotic process	Cflar	IGI	MGI:MGI:104798	Mouse	PMID:21368763
Biological Process	GO:0043066	negative regulation of apoptotic process	Cflar	IMP		Mouse	PMID:16263940
Biological Process	GO:0043066	negative regulation of apoptotic process	Cflar	IMP		Rat	PMID:12135878|RGD:632417
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Cflar	IMP		Rat	PMID:14596792|RGD:11341703
Biological Process	GO:1903845	negative regulation of cellular response to transforming growth factor beta stimulus	Cflar	IMP		Rat	PMID:18314484|RGD:11341711
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Cflar	IMP		Mouse	PMID:16263940
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Cflar	IDA		Rat	PMID:18314484|RGD:11341711
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	CFLAR	IMP		Human	PMID:22266862
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	CFLAR	IDA		Human	PMID:9208847
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Cflar	IGI	MGI:MGI:2154952	Mouse	PMID:22675671
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Cflar	IGI	MGI:MGI:109324	Mouse	PMID:22675671
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	CFLAR	IDA		Human	PMID:26582200
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	CFLAR	IMP		Human	PMID:18202225
Biological Process	GO:1903944	negative regulation of hepatocyte apoptotic process	Cflar	IMP		Rat	PMID:16167066|RGD:11341697
Biological Process	GO:1901740	negative regulation of myoblast fusion	Cflar	IMP		Mouse	MGI:MGI:5707584|PMID:21364645
Biological Process	GO:0060546	negative regulation of necroptotic process	Cflar	IGI	MGI:MGI:2154952	Mouse	PMID:21368763
Biological Process	GO:0060546	negative regulation of necroptotic process	Cflar	IGI	MGI:MGI:104798	Mouse	PMID:21368763
Biological Process	GO:0060546	negative regulation of necroptotic process	Cflar	IGI	MGI:MGI:2154952	Mouse	PMID:22675671
Biological Process	GO:0060546	negative regulation of necroptotic process	Cflar	IGI	MGI:MGI:104798	Mouse	PMID:22089168
Biological Process	GO:0060546	negative regulation of necroptotic process	Cflar	IGI	MGI:MGI:1261423	Mouse	PMID:21368763
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	Cflar	IMP		Rat	PMID:18292530|RGD:11341712
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Cflar	IMP		Rat	PMID:23412386|RGD:11341713
Biological Process	GO:1903055	positive regulation of extracellular matrix organization	Cflar	IMP		Rat	PMID:24691542|RGD:11341715
Biological Process	GO:0072126	positive regulation of glomerular mesangial cell proliferation	Cflar	IMP		Rat	PMID:24691542|RGD:11341715
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	Cflar	IMP		Rat	PMID:16033771|RGD:11341689
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	CFLAR	IEP		Human	PMID:12761501
Biological Process	GO:0010976	positive regulation of neuron projection development	Cflar	IMP		Rat	PMID:20427667|RGD:11341704
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Cflar	IMP		Mouse	MGI:MGI:5707584|PMID:21364645
Biological Process	GO:0060544	regulation of necroptotic process	CFLAR	IDA		Human	PMID:21737330
Biological Process	GO:0014842	regulation of skeletal muscle satellite cell proliferation	Cflar	IMP		Mouse	MGI:MGI:5707584|PMID:21364645
Biological Process	GO:0009617	response to bacterium	Cflar	IEP		Mouse	PMID:23012479
Biological Process	GO:0001666	response to hypoxia	Cflar	IEP		Rat	PMID:23926673|RGD:11341700
Biological Process	GO:0033574	response to testosterone	Cflar	IDA		Rat	PMID:12811833|RGD:1299295
Biological Process	GO:0014732	skeletal muscle atrophy	Cflar	IMP		Mouse	MGI:MGI:5707584|PMID:21364645
Biological Process	GO:0007519	skeletal muscle tissue development	Cflar	IMP		Mouse	MGI:MGI:5707584|PMID:21364645
Biological Process	GO:0043403	skeletal muscle tissue regeneration	Cflar	IMP		Mouse	MGI:MGI:5707584|PMID:21364645
Biological Process	GO:0014866	skeletal myofibril assembly	Cflar	IMP		Mouse	MGI:MGI:5707584|PMID:21364645
Biological Process	GO:0042060	wound healing	Cflar	IMP		Mouse	MGI:MGI:5707584|PMID:21364645

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern