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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cftr

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cftr
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005524ATP bindingcftrIDAZfishPMID:28735752
Molecular FunctionGO:0016887ATP hydrolysis activityCFTRIDAHumanPMID:11524016
Molecular FunctionGO:0016887ATP hydrolysis activityCFTRIDAHumanPMID:8910473
Molecular FunctionGO:0016887ATP hydrolysis activitycftrIDAZfishPMID:27912062
Molecular FunctionGO:0015106bicarbonate transmembrane transporter activityCFTRIDAHumanPMID:15010471
Molecular FunctionGO:0015106bicarbonate transmembrane transporter activityCFTRIDAHumanPMID:19019741
Molecular FunctionGO:0015106bicarbonate transmembrane transporter activityCftrIMPMouseMGI:MGI:5429843|PMID:21976599
Molecular FunctionGO:0005254chloride channel activityCFTRIDAHumanPMID:11524016
Molecular FunctionGO:0005254chloride channel activityCFTRIDAHumanPMID:11707463
Molecular FunctionGO:0005254chloride channel activityCFTRIDAHumanPMID:15010471
Molecular FunctionGO:0005254chloride channel activityCFTRIDAHumanPMID:18570918
Molecular FunctionGO:0005254chloride channel activityCFTRIDAHumanPMID:19019741
Molecular FunctionGO:0005254chloride channel activityCFTRIMPHumanPMID:19621064
Molecular FunctionGO:0005254chloride channel activityCFTRIDAHumanPMID:22178883
Molecular FunctionGO:0005254chloride channel activityCFTRIMPHumanPMID:24885604
Molecular FunctionGO:0005254chloride channel activityCftrIMPMouseMGI:MGI:5640937|PMID:24885604
Molecular FunctionGO:0005254chloride channel activityCftrIDAMouseMGI:MGI:4439399|PMID:20231442
Molecular FunctionGO:0005254chloride channel activitycftrIDAZfishPMID:32123813
Molecular FunctionGO:0019869chloride channel inhibitor activityCFTRIDAHumanPMID:22178883
Molecular FunctionGO:0015108chloride transmembrane transporter activityCftrIMPMouseMGI:MGI:5429843|PMID:21976599
Molecular FunctionGO:0019899enzyme bindingCFTRIPIUniProtKB:Q14694HumanPMID:19398555
Molecular FunctionGO:0005260intracellularly ATP-gated chloride channel activityCFTRIMPHumanPMID:8910473
Molecular FunctionGO:0030165PDZ domain bindingCFTRIDAHumanPMID:11707463
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q9HD26HumanPMID:11707463
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q15599HumanPMID:12369822
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:O14745HumanPMID:12471024
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P51790-2HumanPMID:12471024
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q5T2W1HumanPMID:12471024
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q9HD26HumanPMID:12471024
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P98082HumanPMID:15247260
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q9UM54-1HumanPMID:15247260
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q15599HumanPMID:16203867
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q9HBW0HumanPMID:16203867
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P27824HumanPMID:16546175
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q99942HumanPMID:16901789
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q9BUN8HumanPMID:16901789
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:O14745HumanPMID:17110338
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P27824HumanPMID:17110338
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q15599HumanPMID:17110338
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:O14745HumanPMID:17244609
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q9QX74HumanPMID:17244609
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P51572HumanPMID:18555783
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q7LBE3HumanPMID:19289574
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P19120HumanPMID:19878303
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q7LBE3HumanPMID:20658517
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q9H8Y8HumanPMID:21884936
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P05787HumanPMID:22038833
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P60709HumanPMID:22038833
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q96RN1HumanPMID:22121115
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q5XXA6HumanPMID:22178883
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:O43852-1HumanPMID:22768251
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q9P0N8HumanPMID:23818989
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P16615-1HumanPMID:25661196
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P60709HumanPMID:25712891
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:O15554HumanPMID:27092946
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:O14745HumanPMID:28360110
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q15599HumanPMID:28360110
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q9HD26HumanPMID:28360110
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P27824HumanPMID:29924966
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P60709HumanPMID:29924966
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:O14745HumanPMID:31324722
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P07384HumanPMID:31324722
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P27824HumanPMID:31324722
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q15599HumanPMID:31324722
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:Q9HD26HumanPMID:31324722
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:O14745HumanPMID:9671706
Molecular FunctionGO:0005515protein bindingCFTRIPIUniProtKB:P60468HumanPMID:9792704
Molecular FunctionGO:0005515protein bindingCftrIPIUniProtKB:Q80SW1MouseMGI:MGI:5634882|PMID:23542070
Molecular FunctionGO:0005515protein bindingCftrIPIUniProtKB:P70441|UniProtKB:Q8CIW6|UniProtKB:Q9WVC8MouseMGI:MGI:5429843|PMID:21976599
Molecular FunctionGO:0005515protein bindingCftrIPIUniProtKB:Q80SW1MouseMGI:MGI:3831619|PMID:19033647
Molecular FunctionGO:0005515protein bindingCftrIPIUniProtKB:Q8CIW6MouseMGI:MGI:5429843|PMID:21976599
Molecular FunctionGO:0005515protein bindingCftrIPIUniProtKB:P19120MouseMGI:MGI:5508577|PMID:19878303
Molecular FunctionGO:0005515protein bindingCftrIPIUniProtKB:P70441|UniProtKB:Q9WVC8MouseMGI:MGI:5429843|PMID:21976599
Molecular FunctionGO:0005515protein bindingCftrIPIRGD:68433RatPMID:25270793|RGD:11567217
Molecular FunctionGO:0051087protein-folding chaperone bindingCFTRIPIUniProtKB:O95816HumanPMID:16207813
Molecular FunctionGO:0106138Sec61 translocon complex bindingCFTRIDAHumanPMID:9792704
Cellular ComponentGO:0016324apical plasma membraneCFTRIDAHumanPMID:12801959
Cellular ComponentGO:0016324apical plasma membraneCFTRIDAHumanPMID:15247260
Cellular ComponentGO:0016324apical plasma membraneCFTRIDAHumanPMID:18570918
Cellular ComponentGO:0016324apical plasma membraneCFTRIMPHumanPMID:19621064
Cellular ComponentGO:0016324apical plasma membraneCFTRIDAHumanPMID:20658517
Cellular ComponentGO:0016324apical plasma membraneCFTRIDAHumanPMID:28130590
Cellular ComponentGO:0016324apical plasma membraneCFTRIDAHumanPMID:32487539
Cellular ComponentGO:0016324apical plasma membraneCftrIDAMouseMGI:MGI:5289719|PMID:21884936
Cellular ComponentGO:0016324apical plasma membraneCftrIDAMousePMID:16537650
Cellular ComponentGO:0016324apical plasma membraneCftrIDARatPMID:11083465|RGD:724710
Cellular ComponentGO:0016324apical plasma membraneCftrIDARatPMID:24598307|RGD:35673329
Cellular ComponentGO:0016324apical plasma membranecftrIDAZfishPMID:25592226
Cellular ComponentGO:0016323basolateral plasma membraneCftrIDARatPMID:16575514|RGD:1600701
Cellular ComponentGO:0009986cell surfaceCFTRIDAHumanPMID:20658517
Cellular ComponentGO:0005737cytoplasmCFTRIDAHumanPMID:18570918
Cellular ComponentGO:0005737cytoplasmCftrIDARatPMID:16575514|RGD:1600701
Cellular ComponentGO:0030659cytoplasmic vesicle membraneCftrIDARatPMID:11083465|RGD:724710
Cellular ComponentGO:0005829cytosolCFTRIDAHumanPMID:24885604
Cellular ComponentGO:0005829cytosolCftrIDAMouseMGI:MGI:5640937|PMID:24885604
Cellular ComponentGO:0030425dendriteCftrIDARatPMID:7529593|RGD:11566043
Cellular ComponentGO:0005769early endosomeCFTRIDAHumanPMID:19398555
Cellular ComponentGO:0005769early endosomeCftrIDARatPMID:7521124|RGD:11567228
Cellular ComponentGO:0005789endoplasmic reticulum membraneCFTRIDAHumanPMID:11707463
Cellular ComponentGO:0016020membraneCFTRIDAHumanPMID:8910473
Cellular ComponentGO:0005902microvillusCftrIDARatPMID:16575514|RGD:1600701
Cellular ComponentGO:0043025neuronal cell bodyCftrIDARatPMID:7529593|RGD:11566043
Cellular ComponentGO:0005634nucleusCftrIDARatPMID:29453757|RGD:13514091
Cellular ComponentGO:0005886plasma membraneCFTRIDAHumanPMID:11524016
Cellular ComponentGO:0005886plasma membraneCFTRIMPHumanPMID:11707463
Cellular ComponentGO:0005886plasma membraneCFTRIDAHumanPMID:15010471
Cellular ComponentGO:0005886plasma membraneCFTRIDAHumanPMID:21884936
Cellular ComponentGO:0005886plasma membraneCFTRIDAHumanPMID:22178883
Cellular ComponentGO:0005886plasma membraneCFTRIDAHumanPMID:24885604
Cellular ComponentGO:0005886plasma membraneCFTRIDAHumanPMID:28067262
Cellular ComponentGO:0005886plasma membraneCFTRIDAHumanPMID:28130590
Cellular ComponentGO:0005886plasma membraneCftrIDAMouseMGI:MGI:5640937|PMID:24885604
Cellular ComponentGO:0032991protein-containing complexCFTRIDAHumanPMID:17462998
Cellular ComponentGO:0055037recycling endosomeCFTRIDAHumanPMID:18570918
Biological ProcessGO:0007568agingCftrIEPRatPMID:25546515|RGD:11566048
Biological ProcessGO:0097186amelogenesisCftrIDAMouseMGI:MGI:6716964|PMID:26403673
Biological ProcessGO:0015701bicarbonate transportCFTRIDAHumanPMID:15010471
Biological ProcessGO:0015701bicarbonate transportCFTRIDAHumanPMID:19019741
Biological ProcessGO:0015701bicarbonate transportCftrIMPRatPMID:19657734|RGD:2314618
Biological ProcessGO:0071454cellular response to anoxiaCftrIEPRatPMID:14975182|RGD:1599599
Biological ProcessGO:0071320cellular response to cAMPCftrIDAMouseMGI:MGI:5429843|PMID:21976599
Biological ProcessGO:1904322cellular response to forskolinCFTRIDAHumanPMID:15010471
Biological ProcessGO:1904322cellular response to forskolinCFTRIDAHumanPMID:19621064
Biological ProcessGO:0034605cellular response to heatCftrIEPRatPMID:22777528|RGD:11567213
Biological ProcessGO:0032870cellular response to hormone stimulusCftrIEPRatPMID:17595518|RGD:2314620
Biological ProcessGO:1902476chloride transmembrane transportCFTRIDAHumanPMID:11524016
Biological ProcessGO:1902476chloride transmembrane transportCFTRIDAHumanPMID:11707463
Biological ProcessGO:1902476chloride transmembrane transportCFTRIDAHumanPMID:19019741
Biological ProcessGO:1902476chloride transmembrane transportCFTRIMPHumanPMID:19621064
Biological ProcessGO:1902476chloride transmembrane transportCFTRIMPHumanPMID:24885604
Biological ProcessGO:1902476chloride transmembrane transportCftrIDAMouseMGI:MGI:4439399|PMID:20231442
Biological ProcessGO:1902476chloride transmembrane transportCftrIDAMouseMGI:MGI:6716964|PMID:26403673
Biological ProcessGO:1902476chloride transmembrane transportCftrIMPMouseMGI:MGI:5640937|PMID:24885604
Biological ProcessGO:0006821chloride transportCftrIGIMGI:MGI:2385184MousePMID:19033647
Biological ProcessGO:0006821chloride transportCftrIMPRatPMID:19684200|RGD:2314617
Biological ProcessGO:0006695cholesterol biosynthetic processCftrIMPMGI:MGI:1856709MousePMID:17085523
Biological ProcessGO:0030301cholesterol transportCftrIMPMGI:MGI:1856709MousePMID:17085523
Biological ProcessGO:0042742defense response to bacteriumcftrIMPZFIN:ZDB-MRPHLNO-190805-1ZfishPMID:30759393
Biological ProcessGO:0042742defense response to bacteriumcftrIMPZFIN:ZDB-MRPHLNO-101104-1,ZFIN:ZDB-MRPHLNO-101104-2ZfishPMID:20732993
Biological ProcessGO:0035162embryonic hemopoiesiscftrIMPZFIN:ZDB-GENO-190715-7ZfishPMID:29449653
Biological ProcessGO:0035162embryonic hemopoiesiscftrIMPZFIN:ZDB-MRPHLNO-101104-2ZfishPMID:29449653
Biological ProcessGO:0070166enamel mineralizationCftrIMPRatPMID:31942562|RGD:126928119
Biological ProcessGO:0051649establishment of localization in cellCftrIGIMGI:MGI:2385184MousePMID:19033647
Biological ProcessGO:0008354germ cell migrationcftrIMPZFIN:ZDB-GENO-190322-3ZfishPMID:29930176
Biological ProcessGO:0007507heart developmentcftrIMPZFIN:ZDB-GENO-211104-4ZfishPMID:32574800
Biological ProcessGO:0045087innate immune responsecftrIMPZFIN:ZDB-MRPHLNO-190805-1ZfishPMID:32849617
Biological ProcessGO:0045087innate immune responsecftrIMPZFIN:ZDB-GENO-220126-1ZfishPMID:32849617
Biological ProcessGO:0051454intracellular pH elevationCftrIMPMouseMGI:MGI:5429843|PMID:21976599
Biological ProcessGO:0070121Kupffer's vesicle developmentcftrIGIZFIN:ZDB-MRPHLNO-060630-4,ZFIN:ZDB-MRPHLNO-070620-5,ZFIN:ZDB-MRPHLNO-160201-1ZfishPMID:26432887
Biological ProcessGO:0070121Kupffer's vesicle developmentcftrIMPZFIN:ZDB-MRPHLNO-160201-1ZfishPMID:26432887
Biological ProcessGO:0070121Kupffer's vesicle developmentcftrIMPZFIN:ZDB-GENO-131101-2ZfishPMID:23487313
Biological ProcessGO:0097421liver regenerationCftrIEPRatPMID:1378998|RGD:11567227
Biological ProcessGO:0030324lung developmentCftrIMPRatPMID:15694001|RGD:1599597
Biological ProcessGO:0097535lymphoid lineage cell migration into thymuscftrIMPZFIN:ZDB-GENO-221227-3ZfishPMID:33951474
Biological ProcessGO:0060081membrane hyperpolarizationCftrIMPMouseMGI:MGI:5429843|PMID:21976599
Biological ProcessGO:0050891multicellular organismal-level water homeostasisCFTRIMPHumanPMID:19621064
Biological ProcessGO:2000077negative regulation of type B pancreatic cell developmentCftrIMPRatPMID:23178930|RGD:11567224
Biological ProcessGO:1905460negative regulation of vascular associated smooth muscle cell apoptotic processCftrIMPRatPMID:24999019|RGD:11567225
Biological ProcessGO:0031016pancreas developmentcftrIMPZFIN:ZDB-GENO-131101-2ZfishPMID:26153247
Biological ProcessGO:1902161positive regulation of cyclic nucleotide-gated ion channel activityCFTRIMPHumanPMID:24885604
Biological ProcessGO:1902161positive regulation of cyclic nucleotide-gated ion channel activityCftrIMPMouseMGI:MGI:5640937|PMID:24885604
Biological ProcessGO:0070175positive regulation of enamel mineralizationCftrIDAMouseMGI:MGI:6716964|PMID:26403673
Biological ProcessGO:1904446positive regulation of establishment of Sertoli cell barrierCftrIMPRatPMID:22777528|RGD:11567213
Biological ProcessGO:0045921positive regulation of exocytosisCFTRIMPHumanPMID:24885604
Biological ProcessGO:0045921positive regulation of exocytosisCftrIMPMouseMGI:MGI:5640937|PMID:24885604
Biological ProcessGO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulusCFTRIGIUniProtKB:Q5XXA6HumanPMID:24885604
Biological ProcessGO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulusCFTRIMPHumanPMID:24885604
Biological ProcessGO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulusCftrIMPMouseMGI:MGI:5640937|PMID:24885604
Biological ProcessGO:0033005positive regulation of mast cell activationCftrIMPRatPMID:11781380|RGD:11567226
Biological ProcessGO:1902943positive regulation of voltage-gated chloride channel activityCFTRIDAHumanPMID:22006324
Biological ProcessGO:0090022regulation of neutrophil chemotaxiscftrIMPZFIN:ZDB-MRPHLNO-101104-1,ZFIN:ZDB-MRPHLNO-101104-2ZfishPMID:20732993
Biological ProcessGO:0002679respiratory burst involved in defense responsecftrIMPZFIN:ZDB-MRPHLNO-101104-1,ZFIN:ZDB-MRPHLNO-101104-2ZfishPMID:20732993
Biological ProcessGO:0034097response to cytokineCftrIEPRatPMID:16051699|RGD:2314622
Biological ProcessGO:0034976response to endoplasmic reticulum stressCFTRIDAHumanPMID:21884936
Biological ProcessGO:0034976response to endoplasmic reticulum stressCFTRIDAHumanPMID:28067262
Biological ProcessGO:0043627response to estrogenCftrIEPRatPMID:16051669|RGD:1599595
Biological ProcessGO:0043434response to peptide hormoneCftrIEPRatPMID:16614390|RGD:1599594
Biological ProcessGO:0009410response to xenobiotic stimulusCftrIEPRatPMID:16916328|RGD:1599592
Biological ProcessGO:0009410response to xenobiotic stimulusCftrIMPRatPMID:31942562|RGD:126928119
Biological ProcessGO:0035725sodium ion transmembrane transportCftrIMPRatPMID:31942562|RGD:126928119
Biological ProcessGO:0060063Spemann organizer formation at the embryonic shieldcftrIMPZFIN:ZDB-GENO-230303-1ZfishPMID:33063835
Biological ProcessGO:0048240sperm capacitationCftrIMPMouseMGI:MGI:5429843|PMID:21976599
Biological ProcessGO:0030217T cell differentiationcftrIMPZFIN:ZDB-GENO-221227-3ZfishPMID:33951474
Biological ProcessGO:0030321transepithelial chloride transportCftrIMPRatPMID:17122162|RGD:1599591
Biological ProcessGO:0030321transepithelial chloride transportCftrIMPRatPMID:31942562|RGD:126928119
Biological ProcessGO:0035377transepithelial water transportCFTRIMPHumanPMID:19621064
Biological ProcessGO:0042311vasodilationCftrIMPRatPMID:16859673|RGD:1599593
Biological ProcessGO:0042311vasodilationCftrIDARatPMID:17596272|RGD:2314621
Biological ProcessGO:0006904vesicle docking involved in exocytosisCftrIMPMouseMGI:MGI:5640937|PMID:24885604
Biological ProcessGO:0006833water transportCftrIMPRatPMID:19657734|RGD:2314618

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory