Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHAC1
  • Mouse genes Chac1
  • Rat genes Chac1
  • Zfish genes chac1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chac1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005112	Notch binding	Chac1	IDA		Mouse	MGI:MGI:5319736|PMID:22445366
Molecular Function	GO:0005515	protein binding	CHAC1	IPI	UniProtKB:Q9BQY4	Human	PMID:16189514
Cellular Component	GO:0005829	cytosol	CHAC1	IDA		Human	PMID:19109178
Cellular Component	GO:0005802	trans-Golgi network	Chac1	IDA		Mouse	MGI:MGI:5319736|PMID:22445366
Biological Process	GO:0006751	glutathione catabolic process	chac1	IDA		Zfish	PMID:31189567
Biological Process	GO:0006751	glutathione catabolic process	chac1	IMP	ZFIN:ZDB-MRPHLNO-200207-1	Zfish	PMID:31189567
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	CHAC1	IMP		Human	PMID:19109178
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	CHAC1	IMP		Human	PMID:22445366
Biological Process	GO:0010955	negative regulation of protein processing	CHAC1	IMP		Human	PMID:22445366
Biological Process	GO:0022008	neurogenesis	Chac1	IMP		Mouse	MGI:MGI:5319736|PMID:22445366

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern