Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHD4
  • Mouse genes Chd4
  • Rat genes Chd4
  • Zfish genes chd4a,chd4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chd4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016887	ATP hydrolysis activity	CHD4	IDA		Human	PMID:28977666
Molecular Function	GO:0140658	ATP-dependent chromatin remodeler activity	CHD4	IDA		Human	PMID:28977666
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Chd4	IPI	UniProtKB:Q60707	Mouse	MGI:MGI:6710296|PMID:33795231
Molecular Function	GO:0042826	histone deacetylase binding	CHD4	IPI	UniProtKB:Q13547	Human	PMID:27616479
Molecular Function	GO:0031492	nucleosomal DNA binding	CHD4	HDA		Human	PMID:16217013
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:Q13547	Human	PMID:10220385
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:P01106	Human	PMID:17314511
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:Q8N5A5	Human	PMID:19644445
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:Q13547	Human	PMID:20693977
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:Q13547	Human	PMID:21258344
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:O60885	Human	PMID:21555454
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:Q8IWS0	Human	PMID:22720776
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:Q13547	Human	PMID:23752268
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:Q17R98	Human	PMID:25150861
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:P70326	Human	PMID:26859351
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:Q13547	Human	PMID:26949739
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:Q13547	Human	PMID:28977666
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:Q9ULU4	Human	PMID:30134174
Molecular Function	GO:0005515	protein binding	CHD4	IPI	UniProtKB:P48725	Human	PMID:9804427
Molecular Function	GO:0005515	protein binding	Chd4	IPI	UniProtKB:Q80V81	Mouse	MGI:MGI:5487499|PMID:22674187
Molecular Function	GO:0005515	protein binding	Chd4	IPI	UniProtKB:Q60I23	Mouse	MGI:MGI:5437412|PMID:21532573
Molecular Function	GO:0005515	protein binding	Chd4	IPI	UniProtKB:P70326	Mouse	MGI:MGI:5882294|PMID:26859351
Molecular Function	GO:0005515	protein binding	Chd4	IPI	PR:Q924K8	Mouse	PMID:22075476
Molecular Function	GO:0005515	protein binding	Chd4	IPI	PR:O09106	Mouse	PMID:22075476
Molecular Function	GO:0005515	protein binding	Chd4	IPI	PR:A2BH40	Mouse	PMID:24335282
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	CHD4	IPI	UniProtKB:Q96BF6	Human	PMID:22926524
Molecular Function	GO:0001221	transcription coregulator binding	CHD4	IPI	UniProtKB:Q9H2P0	Human	PMID:29795351
Molecular Function	GO:0003714	transcription corepressor activity	CHD4	IDA		Human	PMID:33859416
Molecular Function	GO:0008134	transcription factor binding	Chd4	IPI	PR:Q03267	Mouse	PMID:15767674
Cellular Component	GO:0005813	centrosome	CHD4	IDA		Human	PMID:17626165
Cellular Component	GO:0150048	cerebellar granule cell to Purkinje cell synapse	Chd4	IDA		Rat	PMID:24991957|RGD:9587770
Cellular Component	GO:0150048	cerebellar granule cell to Purkinje cell synapse	Chd4	IMP		Rat	PMID:24991957|RGD:9587770
Cellular Component	GO:0000785	chromatin	CHD4	HDA		Human	PMID:16217013
Cellular Component	GO:0000781	chromosome, telomeric region	CHD4	IDA		Human	PMID:25150861
Cellular Component	GO:0005737	cytoplasm	CHD4	IDA		Human	PMID:17626165
Cellular Component	GO:0016020	membrane	CHD4	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	CHD4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CHD4	IDA		Human	PMID:22720776
Cellular Component	GO:0005634	nucleus	CHD4	IDA		Human	PMID:28977666
Cellular Component	GO:0005634	nucleus	CHD4	IDA		Human	PMID:33283408
Cellular Component	GO:0005634	nucleus	Chd4	IDA		Mouse	PMID:20720167
Cellular Component	GO:0016581	NuRD complex	CHD4	IDA		Human	PMID:19644445
Cellular Component	GO:0016581	NuRD complex	CHD4	IDA		Human	PMID:33283408
Cellular Component	GO:0016581	NuRD complex	Chd4	IDA		Mouse	PMID:22075476
Cellular Component	GO:0032991	protein-containing complex	CHD4	HDA		Human	PMID:16217013
Cellular Component	GO:0032991	protein-containing complex	Chd4	IDA		Mouse	PMID:19796622
Cellular Component	GO:0032993	protein-DNA complex	Chd4	IDA		Mouse	PMID:21245044
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	CHD4	IDA		Human	PMID:29795351
Cellular Component	GO:0090734	site of DNA damage	CHD4	IDA		Human	PMID:25593309
Biological Process	GO:0006338	chromatin remodeling	CHD4	HDA		Human	PMID:16217013
Biological Process	GO:0006338	chromatin remodeling	CHD4	IDA		Human	PMID:9790534
Biological Process	GO:0000724	double-strand break repair via homologous recombination	CHD4	IMP		Human	PMID:25593309
Biological Process	GO:0031101	fin regeneration	chd4a	IMP	ZFIN:ZDB-MRPHLNO-140930-3	Zfish	PMID:24779377
Biological Process	GO:0031101	fin regeneration	chd4a	IMP	ZFIN:ZDB-MRPHLNO-140930-4	Zfish	PMID:24779377
Biological Process	GO:0016575	histone deacetylation	CHD4	IDA		Human	PMID:10444591
Biological Process	GO:0010629	negative regulation of gene expression	CHD4	IGI	UniProtKB:Q86VK4	Human	PMID:33301730
Biological Process	GO:0010629	negative regulation of gene expression	CHD4	IDA		Human	PMID:33859416
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Chd4	IMP		Rat	PMID:18456662|RGD:9587768
Biological Process	GO:0051963	regulation of synapse assembly	Chd4	IDA		Rat	PMID:24991957|RGD:9587770
Biological Process	GO:0051963	regulation of synapse assembly	Chd4	IMP		Rat	PMID:24991957|RGD:9587770
Biological Process	GO:0072553	terminal button organization	Chd4	IMP		Rat	PMID:24991957|RGD:9587770

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern