Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Chd8

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CHD8
- Mouse genes Chd8
- Rat genes Chd8
- Zfish genes chd8
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chd8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070016	armadillo repeat domain binding	Chd8	IPI	RGD:70487	Rat	PMID:10921920\|RGD:631965
Molecular Function	GO:0005524	ATP binding	CHD8	IDA		Human	PMID:18378692
Molecular Function	GO:0140658	ATP-dependent chromatin remodeler activity	CHD8	IDA		Human	PMID:18378692
Molecular Function	GO:0008013	beta-catenin binding	CHD8	IDA		Human	PMID:18378692
Molecular Function	GO:0008013	beta-catenin binding	CHD8	IDA		Human	PMID:22083958
Molecular Function	GO:0008013	beta-catenin binding	Chd8	IDA		Rat	PMID:10921920\|RGD:631965
Molecular Function	GO:0008013	beta-catenin binding	Chd8	IDA		Rat	PMID:11744694\|RGD:8553770
Molecular Function	GO:0003682	chromatin binding	CHD8	IDA		Human	PMID:22083958
Molecular Function	GO:0003682	chromatin binding	Chd8	IDA		Mouse	PMID:27602517
Molecular Function	GO:0003677	DNA binding	CHD8	IMP		Human	PMID:18378692
Molecular Function	GO:0003677	DNA binding	Chd8	IDA		Mouse	MGI:MGI:3839031\|PMID:19151705
Molecular Function	GO:0042393	histone binding	Chd8	IDA		Mouse	MGI:MGI:3839031\|PMID:19151705
Molecular Function	GO:0042393	histone binding	Chd8	IPI	PR:P15864	Mouse	PMID:22083958
Molecular Function	GO:0035064	methylated histone binding	CHD8	IDA		Human	PMID:17938208
Molecular Function	GO:0002039	p53 binding	Chd8	IPI	UniProtKB:P04637	Mouse	MGI:MGI:3839031\|PMID:19151705
Molecular Function	GO:0005515	protein binding	CHD8	IPI	UniProtKB:P61964	Human	PMID:15960975
Molecular Function	GO:0005515	protein binding	CHD8	IPI	UniProtKB:P52747	Human	PMID:17938208
Molecular Function	GO:0005515	protein binding	CHD8	IPI	UniProtKB:P61964	Human	PMID:18378692
Molecular Function	GO:0005515	protein binding	CHD8	IPI	UniProtKB:P61964	Human	PMID:20085832
Molecular Function	GO:0005515	protein binding	CHD8	IPI	UniProtKB:Q15291	Human	PMID:20085832
Molecular Function	GO:0005515	protein binding	CHD8	IPI	UniProtKB:Q9UBL3	Human	PMID:20085832
Molecular Function	GO:0005515	protein binding	CHD8	IPI	UniProtKB:Q9P2D1	Human	PMID:20453063
Molecular Function	GO:0005515	protein binding	CHD8	IPI	UniProtKB:O95365	Human	PMID:26816381
Molecular Function	GO:0005515	protein binding	CHD8	IPI	UniProtKB:O00154	Human	PMID:26949739
Molecular Function	GO:0005515	protein binding	Chd8	IPI	UniProtKB:P28033	Mouse	MGI:MGI:6278776\|PMID:29768199
Molecular Function	GO:0005515	protein binding	Chd8	IPI	UniProtKB:Q61164	Mouse	MGI:MGI:3663239\|PMID:16949368
Molecular Function	GO:0005515	protein binding	Chd8	IPI	PR:Q09XV5	Mouse	PMID:27602517
Molecular Function	GO:0005515	protein binding	Chd8	IPI	UniProtKB:O35344	Rat	PMID:11744694\|RGD:8553770
Cellular Component	GO:0071339	MLL1 complex	CHD8	IDA		Human	PMID:15960975
Cellular Component	GO:0005654	nucleoplasm	CHD8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CHD8	IDA		Human	PMID:18378692
Cellular Component	GO:0005634	nucleus	CHD8	IDA		Human	PMID:20453063
Cellular Component	GO:0005634	nucleus	Chd8	IDA		Mouse	MGI:MGI:3839031\|PMID:19151705
Cellular Component	GO:0005634	nucleus	Chd8	IDA		Rat	PMID:10921920\|RGD:631965
Cellular Component	GO:0005634	nucleus	Chd8	IDA		Rat	PMID:11744694\|RGD:8553770
Cellular Component	GO:0032991	protein-containing complex	CHD8	IDA		Human	PMID:18378692
Cellular Component	GO:0032991	protein-containing complex	Chd8	IDA		Rat	PMID:11744694\|RGD:8553770
Biological Process	GO:0007420	brain development	CHD8	IMP		Human	PMID:24998929
Biological Process	GO:0007420	brain development	Chd8	IMP	MGI:MGI:3530648	Mouse	PMID:27602517
Biological Process	GO:0007420	brain development	chd8	IMP		Zfish	PMID:25294932\|ZFIN:ZDB-PUB-141009-2
Biological Process	GO:0007420	brain development	chd8	IMP	ZFIN:ZDB-MRPHLNO-141014-3	Zfish	PMID:25294932
Biological Process	GO:0006338	chromatin remodeling	CHD8	IMP		Human	PMID:18378692
Biological Process	GO:0048565	digestive tract development	CHD8	IMP		Human	PMID:24998929
Biological Process	GO:0048565	digestive tract development	Chd8	IMP	MGI:MGI:3530648	Mouse	PMID:27602517
Biological Process	GO:0048484	enteric nervous system development	chd8	IMP		Zfish	PMID:24998929\|ZFIN:ZDB-PUB-140708-2
Biological Process	GO:0048484	enteric nervous system development	chd8	IMP	ZFIN:ZDB-MRPHLNO-141014-2	Zfish	PMID:24998929
Biological Process	GO:0048484	enteric nervous system development	chd8	IMP	ZFIN:ZDB-MRPHLNO-141014-1	Zfish	PMID:24998929
Biological Process	GO:0048484	enteric nervous system development	chd8	IMP	ZFIN:ZDB-CRISPR-141021-1	Zfish	PMID:24998929
Biological Process	GO:0048484	enteric nervous system development	chd8	IMP	ZFIN:ZDB-MRPHLNO-141014-3	Zfish	PMID:24998929
Biological Process	GO:0048484	enteric nervous system development	chd8	IMP	ZFIN:ZDB-MRPHLNO-141014-4	Zfish	PMID:24998929
Biological Process	GO:0030900	forebrain development	chd8	IMP		Zfish	PMID:24998929\|ZFIN:ZDB-PUB-140708-2
Biological Process	GO:0060322	head development	chd8	IMP	ZFIN:ZDB-CRISPR-141021-1	Zfish	PMID:24998929
Biological Process	GO:0060322	head development	chd8	IMP	ZFIN:ZDB-MRPHLNO-141014-1	Zfish	PMID:24998929
Biological Process	GO:0060322	head development	chd8	IMP	ZFIN:ZDB-MRPHLNO-141014-3	Zfish	PMID:24998929
Biological Process	GO:0060322	head development	chd8	IMP	ZFIN:ZDB-MRPHLNO-141014-4	Zfish	PMID:24998929
Biological Process	GO:0060322	head development	chd8	IMP	ZFIN:ZDB-MRPHLNO-141014-2	Zfish	PMID:24998929
Biological Process	GO:0001701	in utero embryonic development	Chd8	IMP	MGI:MGI:3530648	Mouse	PMID:15367660
Biological Process	GO:0030901	midbrain development	chd8	IMP		Zfish	PMID:24998929\|ZFIN:ZDB-PUB-140708-2
Biological Process	GO:0043066	negative regulation of apoptotic process	Chd8	IDA		Mouse	MGI:MGI:3839031\|PMID:19151705
Biological Process	GO:0043066	negative regulation of apoptotic process	Chd8	IMP		Mouse	MGI:MGI:3055265\|PMID:15367660
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	CHD8	IDA		Human	PMID:22083958
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	CHD8	IDA		Human	PMID:18378692
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Chd8	IDA		Rat	PMID:10921920\|RGD:631965
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Chd8	IDA		Rat	PMID:11744694\|RGD:8553770
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	CHD8	IMP		Human	PMID:18378692
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Chd8	IDA		Mouse	MGI:MGI:3839031\|PMID:19151705
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Chd8	IDA		Rat	PMID:10921920\|RGD:631965
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Chd8	IDA		Rat	PMID:11744694\|RGD:8553770
Biological Process	GO:2000270	negative regulation of fibroblast apoptotic process	Chd8	IDA		Mouse	PMID:19151705
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	chd8	IMP		Zfish	PMID:25294932\|ZFIN:ZDB-PUB-141009-2
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	CHD8	IMP		Human	PMID:25294932
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Chd8	IDA		Rat	PMID:10921920\|RGD:631965
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Chd8	IDA		Rat	PMID:16452319\|RGD:8553394
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CHD8	IDA		Human	PMID:17938208
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	CHD8	IMP		Human	PMID:17938208
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	CHD8	IMP		Human	PMID:25294932
Biological Process	GO:0045945	positive regulation of transcription by RNA polymerase III	CHD8	IMP		Human	PMID:17938208
Biological Process	GO:0060134	prepulse inhibition	Chd8	IMP	MGI:MGI:3530648	Mouse	PMID:27602517
Biological Process	GO:0035176	social behavior	Chd8	IMP	MGI:MGI:3530648	Mouse	PMID:27602517
Biological Process	GO:0001964	startle response	Chd8	IMP	MGI:MGI:3530648	Mouse	PMID:27602517

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.