Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHEK1
  • Mouse genes Chek1
  • Rat genes Chek1
  • Zfish genes chek1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chek1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035402	histone H3T11 kinase activity	CHEK1	IDA		Human	PMID:18243098
Molecular Function	GO:0035402	histone H3T11 kinase activity	Chek1	IDA		Mouse	MGI:MGI:5294291|PMID:18243098
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:P30307	Human	PMID:11836499
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:P38398	Human	PMID:11836499
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:Q06609	Human	PMID:15665856
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:Q9UNS1	Human	PMID:15798197
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:P08238	Human	PMID:16330544
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:P30307	Human	PMID:16330544
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:Q9HAW4	Human	PMID:16963448
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:P06400	Human	PMID:17380128
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:Q96JB5	Human	PMID:19223857
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:Q9UK73	Human	PMID:19330022
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:Q9NRD1	Human	PMID:19716789
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:P61981	Human	PMID:20639859
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:O00255	Human	PMID:20969866
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:Q9UJM3	Human	PMID:22505024
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	CHEK1	IPI	UniProtKB:Q9HCE7-2	Human	PMID:25249323
Molecular Function	GO:0005515	protein binding	Chek1	IPI	UniProtKB:Q9R1X4	Mouse	MGI:MGI:5578016|PMID:23418588
Molecular Function	GO:0005515	protein binding	Chek1	IPI	PR:O88700	Mouse	PMID:15364958
Molecular Function	GO:0005515	protein binding	Chek1	IPI	RGD:728310	Rat	PMID:11687578|RGD:70230
Molecular Function	GO:0019904	protein domain specific binding	CHEK1	IPI	UniProtKB:P54725	Human	PMID:26296656
Molecular Function	GO:0004672	protein kinase activity	CHEK1	IMP		Human	PMID:22024163
Molecular Function	GO:0004672	protein kinase activity	Chek1	IMP		Mouse	PMID:15364958
Molecular Function	GO:0004672	protein kinase activity	Chek1	IDA		Rat	PMID:11278490|RGD:2316109
Molecular Function	GO:0004674	protein serine/threonine kinase activity	CHEK1	IDA		Human	PMID:16963448
Cellular Component	GO:0005813	centrosome	CHEK1	IDA		Human	PMID:15311285
Cellular Component	GO:0000785	chromatin	Chek1	IDA		Mouse	MGI:MGI:5294291|PMID:18243098
Cellular Component	GO:0000781	chromosome, telomeric region	CHEK1	IDA		Human	PMID:15149599
Cellular Component	GO:0000794	condensed nuclear chromosome	CHEK1	IDA		Human	PMID:9382850
Cellular Component	GO:0005737	cytoplasm	CHEK1	IDA		Human	PMID:26296656
Cellular Component	GO:0005615	extracellular space	CHEK1	HDA		Human	PMID:23580065
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CHEK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CHEK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CHEK1	IDA		Human	PMID:15311285
Cellular Component	GO:0005634	nucleus	CHEK1	IDA		Human	PMID:20932473
Cellular Component	GO:0005634	nucleus	CHEK1	IDA		Human	PMID:26296656
Cellular Component	GO:0005634	nucleus	Chek1	IDA		Mouse	PMID:11555636
Cellular Component	GO:0032991	protein-containing complex	CHEK1	IDA		Human	PMID:26296656
Cellular Component	GO:0005657	replication fork	Chek1	IDA		Mouse	PMID:15364958
Biological Process	GO:0006915	apoptotic process	CHEK1	IDA		Human	PMID:23028632
Biological Process	GO:1902742	apoptotic process involved in development	Chek1	IMP	MGI:MGI:1928818	Mouse	PMID:10859163
Biological Process	GO:0071313	cellular response to caffeine	Chek1	IEP		Rat	PMID:11278490|RGD:2316109
Biological Process	GO:0071260	cellular response to mechanical stimulus	CHEK1	IEP		Human	PMID:19593445
Biological Process	GO:0071310	cellular response to organic substance	Chek1	IEP		Rat	PMID:11278490|RGD:2316109
Biological Process	GO:0006338	chromatin remodeling	Chek1	IDA		Mouse	MGI:MGI:5294291|PMID:18243098
Biological Process	GO:0000077	DNA damage checkpoint signaling	CHEK1	IDA		Human	PMID:16963448
Biological Process	GO:0000077	DNA damage checkpoint signaling	CHEK1	IMP		Human	PMID:19716789
Biological Process	GO:0000077	DNA damage checkpoint signaling	Chek1	IMP	MGI:MGI:1926528	Mouse	PMID:10859164
Biological Process	GO:0000077	DNA damage checkpoint signaling	Chek1	IDA		Mouse	PMID:12529385
Biological Process	GO:0006974	DNA damage response	CHEK1	IMP		Human	PMID:20932473
Biological Process	GO:0006974	DNA damage response	Chek1	IMP		Mouse	MGI:MGI:5294291|PMID:18243098
Biological Process	GO:0006974	DNA damage response	Chek1	IDA		Mouse	PMID:11790307
Biological Process	GO:0006974	DNA damage response	Chek1	IDA		Mouse	PMID:12529385
Biological Process	GO:0006281	DNA repair	CHEK1	IMP		Human	PMID:19716789
Biological Process	GO:0006281	DNA repair	Chek1	IDA		Mouse	PMID:15364958
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	Chek1	IMP	MGI:MGI:1926528	Mouse	PMID:10859164
Biological Process	GO:0001833	inner cell mass cell proliferation	Chek1	IMP	MGI:MGI:1928818	Mouse	PMID:10859163
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	chek1	IGI	ZFIN:ZDB-GENO-050428-1,ZFIN:ZDB-MRPHLNO-080804-1	Zfish	PMID:18510930
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	chek1	IGI	ZFIN:ZDB-GENO-050428-4,ZFIN:ZDB-MRPHLNO-080804-1	Zfish	PMID:18510930
Biological Process	GO:0007093	mitotic cell cycle checkpoint signaling	Chek1	IMP	MGI:MGI:1928818	Mouse	PMID:10859163
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	CHEK1	IMP		Human	PMID:20932473
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	chek1	IMP	ZFIN:ZDB-MRPHLNO-080804-1	Zfish	PMID:18510930
Biological Process	GO:0044818	mitotic G2/M transition checkpoint	CHEK1	IMP		Human	PMID:33108758
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	Chek1	IMP		Rat	PMID:12429946|RGD:2316115
Biological Process	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	Chek1	IMP		Rat	PMID:11278490|RGD:2316109
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	Chek1	IMP		Mouse	MGI:MGI:5294291|PMID:18243098
Biological Process	GO:0045839	negative regulation of mitotic nuclear division	CHEK1	IDA		Human	PMID:15311285
Biological Process	GO:0006997	nucleus organization	Chek1	IMP	MGI:MGI:1928818	Mouse	PMID:10859163
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	CHEK1	IDA		Human	PMID:15665856
Biological Process	GO:0045787	positive regulation of cell cycle	CHEK1	IDA		Human	PMID:26296656
Biological Process	GO:0006468	protein phosphorylation	CHEK1	IDA		Human	PMID:33108758
Biological Process	GO:0006468	protein phosphorylation	Chek1	IDA		Mouse	PMID:15364958
Biological Process	GO:0006468	protein phosphorylation	Chek1	IDA		Rat	PMID:11278490|RGD:2316109
Biological Process	GO:0006468	protein phosphorylation	chek1	IMP	ZFIN:ZDB-MRPHLNO-080804-1	Zfish	PMID:18510930
Biological Process	GO:0042127	regulation of cell population proliferation	Chek1	IMP		Mouse	PMID:21737879
Biological Process	GO:0010569	regulation of double-strand break repair via homologous recombination	CHEK1	IDA		Human	PMID:15665856
Biological Process	GO:0010468	regulation of gene expression	Chek1	IGI	MGI:MGI:2443308	Mouse	PMID:21737879
Biological Process	GO:0046602	regulation of mitotic centrosome separation	CHEK1	IDA		Human	PMID:15311285
Biological Process	GO:0042770	signal transduction in response to DNA damage	CHEK1	IDA		Human	PMID:16963448
Biological Process	GO:0042770	signal transduction in response to DNA damage	Chek1	IMP		Rat	PMID:11278490|RGD:2316109

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern