Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHEK2
  • Mouse genes Chek2
  • Rat genes Chek2
  • Zfish genes chek2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chek2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	CHEK2	IPI	UniProtKB:O96017	Human	PMID:16794575
Molecular Function	GO:0042802	identical protein binding	CHEK2	IPI	UniProtKB:O96017	Human	PMID:18239682
Molecular Function	GO:0016301	kinase activity	Chek2	IDA		Rat	PMID:10435585|RGD:633752
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:P30304	Human	PMID:11298456
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:P29590-5	Human	PMID:12402044
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:P53350	Human	PMID:12493754
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q13362-1	Human	PMID:15380617
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q13362-2	Human	PMID:15380617
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q13362-3	Human	PMID:15380617
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q15172	Human	PMID:15380617
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q15173	Human	PMID:15380617
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q16537	Human	PMID:15380617
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:P06725	Human	PMID:16477038
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q9NY61	Human	PMID:17157788
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:P06400	Human	PMID:17380128
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:P55072	Human	PMID:17525332
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q9Y248	Human	PMID:17525332
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q13616	Human	PMID:18644861
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:P27958:PRO_0000037577	Human	PMID:18667510
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:P18887	Human	PMID:18971944
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:P53350	Human	PMID:20126263
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:P56645	Human	PMID:21070773
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:P0C6X7:PRO_0000037319	Human	PMID:22046132
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:O15355	Human	PMID:23178491
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q9UQ88-1	Human	PMID:23178491
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q9NXV6	Human	PMID:24825908
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q13007	Human	PMID:25640309
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q5VTR2	Human	PMID:25640309
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q96KN1	Human	PMID:25640309
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:Q9C0C2	Human	PMID:25749521
Molecular Function	GO:0005515	protein binding	CHEK2	IPI	UniProtKB:O15355	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	Chek2	IPI	RGD:1308649	Rat	PMID:19812253|RGD:10401662
Molecular Function	GO:0042803	protein homodimerization activity	CHEK2	IDA		Human	PMID:16794575
Molecular Function	GO:0004672	protein kinase activity	Chek2	IDA		Mouse	PMID:10710310
Molecular Function	GO:0004672	protein kinase activity	Chek2	IDA		Rat	PMID:11278490|RGD:2316109
Molecular Function	GO:0019901	protein kinase binding	CHEK2	IPI	UniProtKB:Q9H4B4	Human	PMID:16481012
Molecular Function	GO:0004674	protein serine/threonine kinase activity	CHEK2	IDA		Human	PMID:12717439
Molecular Function	GO:0004674	protein serine/threonine kinase activity	CHEK2	IDA		Human	PMID:16794575
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Chek2	IDA		Rat	PMID:10435585|RGD:633752
Molecular Function	GO:0031625	ubiquitin protein ligase binding	CHEK2	IPI	UniProtKB:O76064	Human	PMID:22266820
Cellular Component	GO:0000781	chromosome, telomeric region	CHEK2	IDA		Human	PMID:15149599
Cellular Component	GO:0005794	Golgi apparatus	CHEK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CHEK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Chek2	IDA		Rat	PMID:25344109|RGD:10401635
Cellular Component	GO:0016605	PML body	CHEK2	IDA		Human	PMID:12402044
Biological Process	GO:1903926	cellular response to bisphenol A	Chek2	IEP		Rat	PMID:25344109|RGD:10401635
Biological Process	GO:0071480	cellular response to gamma radiation	Chek2	IMP	MGI:MGI:2386905	Mouse	PMID:10710310
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Chek2	IEP		Rat	PMID:21745814|RGD:10401653
Biological Process	GO:0000077	DNA damage checkpoint signaling	Chek2	IMP		Rat	PMID:10435585|RGD:633752
Biological Process	GO:0006974	DNA damage response	CHEK2	IDA		Human	PMID:24550317
Biological Process	GO:0006974	DNA damage response	CHEK2	IMP		Human	PMID:16481012
Biological Process	GO:0006974	DNA damage response	chek2	IDA		Zfish	PMID:18974873
Biological Process	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	Chek2	IMP	MGI:MGI:2386905	Mouse	PMID:10710310
Biological Process	GO:0006302	double-strand break repair	CHEK2	IMP		Human	PMID:18317453
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	CHEK2	IMP		Human	PMID:16481012
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	CHEK2	IDA		Human	PMID:12402044
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	CHEK2	IMP		Human	PMID:12717439
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	CHEK2	IMP		Human	PMID:18644861
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Chek2	IMP	MGI:MGI:2386905	Mouse	PMID:10710310
Biological Process	GO:0000085	mitotic G2 phase	Chek2	IMP	MGI:MGI:2386905	Mouse	PMID:10710310
Biological Process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	CHEK2	IMP		Human	PMID:11298456
Biological Process	GO:0090307	mitotic spindle assembly	CHEK2	IMP		Human	PMID:20364141
Biological Process	GO:2000002	negative regulation of DNA damage checkpoint	Chek2	IMP		Rat	PMID:20637979|RGD:10401658
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Chek2	IDA		Mouse	PMID:10710310
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Chek2	IDA		Rat	PMID:10435585|RGD:633752
Biological Process	GO:2000210	positive regulation of anoikis	Chek2	IMP		Rat	PMID:21834075|RGD:10401645
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CHEK2	IDA		Human	PMID:17101782
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Chek2	IDA		Rat	PMID:18162465|RGD:10401663
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Chek2	IMP		Rat	PMID:18162465|RGD:10401663
Biological Process	GO:0046777	protein autophosphorylation	CHEK2	IDA		Human	PMID:16794575
Biological Process	GO:0046777	protein autophosphorylation	CHEK2	IDA		Human	PMID:18644861
Biological Process	GO:0030163	protein catabolic process	CHEK2	IMP		Human	PMID:11298456
Biological Process	GO:0006468	protein phosphorylation	CHEK2	IDA		Human	PMID:12717439
Biological Process	GO:0006468	protein phosphorylation	CHEK2	IDA		Human	PMID:18833288
Biological Process	GO:0006468	protein phosphorylation	Chek2	IDA		Rat	PMID:11278490|RGD:2316109
Biological Process	GO:0050821	protein stabilization	CHEK2	IDA		Human	PMID:12717439
Biological Process	GO:0050821	protein stabilization	CHEK2	IDA		Human	PMID:18833288
Biological Process	GO:0051726	regulation of cell cycle	Chek2	IGI	UniprotKB:Q09170	Rat	PMID:10435585|RGD:633752
Biological Process	GO:0006355	regulation of DNA-templated transcription	CHEK2	IDA		Human	PMID:12717439
Biological Process	GO:0042176	regulation of protein catabolic process	CHEK2	IMP		Human	PMID:17101782
Biological Process	GO:0010332	response to gamma radiation	Chek2	IDA		Mouse	PMID:14744935
Biological Process	GO:1903416	response to glycoside	Chek2	IEP		Rat	PMID:19801496|RGD:2317219
Biological Process	GO:0042770	signal transduction in response to DNA damage	CHEK2	IDA		Human	PMID:14744935
Biological Process	GO:0042770	signal transduction in response to DNA damage	CHEK2	IMP		Human	PMID:11298456
Biological Process	GO:0042770	signal transduction in response to DNA damage	Chek2	IDA		Mouse	PMID:14744935
Biological Process	GO:0070242	thymocyte apoptotic process	Chek2	IMP	MGI:MGI:2386905	Mouse	PMID:18614044

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern